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The Effects of Resistance Exercise T...

Sammut, Mitchell James,

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The Effects of Resistance Exercise Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Effects of Resistance Exercise Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes // Mitchell James Sammut.
Author:	Sammut, Mitchell James,
Description:	1 electronic resource (100 pages)
Notes:	Source: Masters Abstracts International, Volume: 85-06.
Contained By:	Masters Abstracts International85-06.
Subject:	Insulin resistance. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30737588
ISBN:	9798381025859

The Effects of Resistance Exercise Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes /
Sammut, Mitchell James,

The Effects of Resistance Exercise Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes /Mitchell James Sammut. - 1 electronic resource (100 pages)

Source: Masters Abstracts International, Volume: 85-06.

The etiology of insulin resistance (IR) development in type 1 diabetes mellitus (T1DM) remains unclear; however, impaired skeletal muscle metabolism may play a role. While IR development has been established in male T1DM rodents, female rodents have yet to be examined in this context. Resistance exercise training (RT) has been shown to improve IR and is associated with a lower risk of hypoglycemia onset in T1DM compared to aerobic exercise. Additionally, the molecular mechanisms mediating RT-induced improvements in insulin sensitivity remain unclear. Therefore, the purpose of this study was to investigate the effects of RT on IR development in female T1DM rodents. Forty Sprague-Dawley eight-week-old female rats were divided into four groups: control sedentary (CS; n=10), control trained (CT; n=10), T1DM sedentary (DS; n=10), T1DM trained (DT; n=10). Multiple low-dose Streptozotocin injections (20 mg/kg each day for seven consecutive days) were used to induce T1DM. Blood glucose levels were maintained in normal range (4-9mmol/L) with intensive insulin therapy (one implanted insulin pellet; 2IU/day). CT and DT underwent weighted ladder climbing 5 days/week for six weeks. Intravenous glucose tolerance tests (IVGTT) were conducted on all animals following the six-week period. Results demonstrate that DS animals exhibited significantly increased weekly blood glucose measures compared to all groups including DT (p<0.0001), despite similar insulin dosage levels. This was concomitant with a significant increase in insulin-adjusted area under the curve following IVGTT in DS (p<0.05), indicative of a reduction in insulin sensitivity. Both DT and DS exhibited greater serum insulin concentrations compared to CT and CS (p<0.05). DS animals also exhibited significantly greater glycogen content in white gastrocnemius muscle compared to all groups (p<0.05) whereas DT and DS animals exhibited greater p-Akt:Akt ratio in white vastus lateralis and citrate synthase activity in red vastus lateralis muscle compared to CS and CT (p<0.05). These results indicate that female rodents with T1DM develop poor glycemic control and IR which can be attenuated with RT, possibly related to differences in intramyocellular glycogen content. This data supports the negative role of elevated muscle glycogen content on insulin sensitivity in T1DM and the potential role of RT in ameliorating these metabolic changes.

English

ISBN: 9798381025859Subjects--Topical Terms:

1016456
Insulin resistance.

The Effects of Resistance Exercise Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes /
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245 1 0 $a The Effects of Resistance Exercise Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes / $c Mitchell James Sammut.
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500 $a Source: Masters Abstracts International, Volume: 85-06.
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520 $a The etiology of insulin resistance (IR) development in type 1 diabetes mellitus (T1DM) remains unclear; however, impaired skeletal muscle metabolism may play a role. While IR development has been established in male T1DM rodents, female rodents have yet to be examined in this context. Resistance exercise training (RT) has been shown to improve IR and is associated with a lower risk of hypoglycemia onset in T1DM compared to aerobic exercise. Additionally, the molecular mechanisms mediating RT-induced improvements in insulin sensitivity remain unclear. Therefore, the purpose of this study was to investigate the effects of RT on IR development in female T1DM rodents. Forty Sprague-Dawley eight-week-old female rats were divided into four groups: control sedentary (CS; n=10), control trained (CT; n=10), T1DM sedentary (DS; n=10), T1DM trained (DT; n=10). Multiple low-dose Streptozotocin injections (20 mg/kg each day for seven consecutive days) were used to induce T1DM. Blood glucose levels were maintained in normal range (4-9mmol/L) with intensive insulin therapy (one implanted insulin pellet; 2IU/day). CT and DT underwent weighted ladder climbing 5 days/week for six weeks. Intravenous glucose tolerance tests (IVGTT) were conducted on all animals following the six-week period. Results demonstrate that DS animals exhibited significantly increased weekly blood glucose measures compared to all groups including DT (p<0.0001), despite similar insulin dosage levels. This was concomitant with a significant increase in insulin-adjusted area under the curve following IVGTT in DS (p<0.05), indicative of a reduction in insulin sensitivity. Both DT and DS exhibited greater serum insulin concentrations compared to CT and CS (p<0.05). DS animals also exhibited significantly greater glycogen content in white gastrocnemius muscle compared to all groups (p<0.05) whereas DT and DS animals exhibited greater p-Akt:Akt ratio in white vastus lateralis and citrate synthase activity in red vastus lateralis muscle compared to CS and CT (p<0.05). These results indicate that female rodents with T1DM develop poor glycemic control and IR which can be attenuated with RT, possibly related to differences in intramyocellular glycogen content. This data supports the negative role of elevated muscle glycogen content on insulin sensitivity in T1DM and the potential role of RT in ameliorating these metabolic changes.
546 $a English
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650 4 $a Insulin resistance. $3 1016456
650 4 $a Lipids. $3 558980
650 4 $a Body mass index. $3 3562858
650 4 $a Viral infections. $3 3540521
650 4 $a Mortality. $3 533218
650 4 $a Health sciences. $3 3168359
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Virology. $3 642304
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710 2 $a The University of Western Ontario (Canada). $e degree granting institution. $3 3759225
720 1 $a Melling, C. W.J. $e degree supervisor.
773 0 $t Masters Abstracts International $g 85-06.
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