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Exploring the Impact of Social Relat...

Jacobson, Maci McCleary,

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Exploring the Impact of Social Relationships, Alcohol Consumption, and Sex Hormones on the Brain's Social Reward Circuitry /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Exploring the Impact of Social Relationships, Alcohol Consumption, and Sex Hormones on the Brain's Social Reward Circuitry // Maci McCleary Jacobson.
作者:	Jacobson, Maci McCleary,
面頁冊數:	1 electronic resource (184 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-08, Section: B.
Contained By:	Dissertations Abstracts International86-08B.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31761615
ISBN:	9798304918312

Exploring the Impact of Social Relationships, Alcohol Consumption, and Sex Hormones on the Brain's Social Reward Circuitry /
Jacobson, Maci McCleary,

Exploring the Impact of Social Relationships, Alcohol Consumption, and Sex Hormones on the Brain's Social Reward Circuitry /Maci McCleary Jacobson. - 1 electronic resource (184 pages)

Source: Dissertations Abstracts International, Volume: 86-08, Section: B.

Properly anticipating and processing social rewards is critical for healthy behavior and social functioning. These processes are disrupted in mood and substance use disorders (SUD), providing context for the detrimental social behaviors (i.e. social withdrawal) often exhibited in these conditions. This is true in human and in animal models. This dissertation utilized functional magnetic resonance imaging (fMRI) and employed within subject and case-control study designs to determine how social, behavioral, and biological factors contribute to individual differences in social reward function, as measured by neural activity in reward regions. The first research chapter examined the impact of social relationship quality on activation in the nucleus accumbens (NAc) during social reward anticipation. Ambivalent and supportive social relationships were compared in their impact on social health and NAc activity. Ambivalent relationships were linked to increased loneliness and reduced NAc activation. The second research chapter investigated the interaction between heavy alcohol use (HAU) and menstrual hormones on NAc activation during social reward anticipation. HAU was associated with blunted NAc activation compared to controls. Menstrual cycle phase did not significantly predict neural response, however, salivary progesterone levels and the progesterone-to-estradiol ratio predicted higher NAc activity during the follicular phase. The final research chapter explored the relationship between the age of alcohol initiation and functional connectivity within and between reward regions and the cognitive control network (CCN). No significant associations were found between the age of initiation and connectivity between the CCN and reward regions. However, earlier initiation was associated with weaker connectivity within CCN regions.These results emphasize the importance of understanding how social, behavioral, and biological factors impact social reward processing. They underscore the need for supportive relationships and factors that delay alcohol initiation, which are crucial for optimizing neural reward responses. These findings have implications for development and implementation of mental health interventions, improving cultural attitudes towards alcohol users exhibiting detrimental social behaviors, and informing public policy (i.e. legal age of drinking). Overall, this dissertation advances the understanding of factors affecting social reward processing, aiming to inform strategies for supporting individuals impacted by poor social health, problematic alcohol use, or both.

English

ISBN: 9798304918312Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Ambivalent relationships

Exploring the Impact of Social Relationships, Alcohol Consumption, and Sex Hormones on the Brain's Social Reward Circuitry /
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