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Multiscale Modeling of the Skin's Bi...

Witt, Nathaniel James,

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Multiscale Modeling of the Skin's Biomechanics and Aging /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Multiscale Modeling of the Skin's Biomechanics and Aging // Nathaniel James Witt.
Author:	Witt, Nathaniel James,
Description:	1 electronic resource (104 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
Contained By:	Dissertations Abstracts International86-01B.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31239017
ISBN:	9798383187616

Multiscale Modeling of the Skin's Biomechanics and Aging /
Witt, Nathaniel James,

Multiscale Modeling of the Skin's Biomechanics and Aging /Nathaniel James Witt. - 1 electronic resource (104 pages)

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

As the population ages and obesity rates rise, the incidence of skin injuries and hospitalizations is projected to escalate. By 2024, the financial burden associated solely with treating chronic wounds is estimated to exceed $22 billion. With advancing age, the skin undergoes notable changes, leading to increased susceptibility to wrinkles, fragility, and compromised wound healing. These alterations stem from shifts in the underlying structure of the skin, particularly within the dermal layer. Reductions in hydrating proteins and disruptions in the collagen network, responsible for skin strength, are key factors in this process. However, comprehending the precise implications of changes in the skin's mechanics and health poses a challenge. While mechanical forces exerted on the skin influence cellular behavior and repair mechanisms, the intricacies of these interactions remain incompletely understood. This is particularly true of the structure-function relationships deriving from the dermal microstructure and their contributions to the biomechanical properties, failure characteristics, and changes with aging of the skin. The studies contained herein aim to investigate these underlying mechanisms via computational models that allow for detailed analysis at the tissue and microstructural levels. Ultimately, this may yield advancements with potential implications for enhancing wound healing and promoting overall skin health in the future.

English

ISBN: 9798383187616Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Collagen network

Multiscale Modeling of the Skin's Biomechanics and Aging /
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100 1 $a Witt, Nathaniel James, $e author. $3 3819225
245 1 0 $a Multiscale Modeling of the Skin's Biomechanics and Aging / $c Nathaniel James Witt.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (104 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
500 $a Advisors: Sander, Edward Committee members: Quinn, Kyle; Raghavan, Suresh; Herrmann, Jacob.
502 $b Ph.D. $c The University of Iowa $d 2024.
520 $a As the population ages and obesity rates rise, the incidence of skin injuries and hospitalizations is projected to escalate. By 2024, the financial burden associated solely with treating chronic wounds is estimated to exceed $22 billion. With advancing age, the skin undergoes notable changes, leading to increased susceptibility to wrinkles, fragility, and compromised wound healing. These alterations stem from shifts in the underlying structure of the skin, particularly within the dermal layer. Reductions in hydrating proteins and disruptions in the collagen network, responsible for skin strength, are key factors in this process. However, comprehending the precise implications of changes in the skin's mechanics and health poses a challenge. While mechanical forces exerted on the skin influence cellular behavior and repair mechanisms, the intricacies of these interactions remain incompletely understood. This is particularly true of the structure-function relationships deriving from the dermal microstructure and their contributions to the biomechanical properties, failure characteristics, and changes with aging of the skin. The studies contained herein aim to investigate these underlying mechanisms via computational models that allow for detailed analysis at the tissue and microstructural levels. Ultimately, this may yield advancements with potential implications for enhancing wound healing and promoting overall skin health in the future.
546 $a English
590 $a School code: 0096
650 4 $a Biomedical engineering. $3 535387
650 4 $a Aging. $3 543123
650 4 $a Biomechanics. $3 548685
650 4 $a Dermatology. $3 829009
653 $a Collagen network
653 $a Dermis
653 $a Fiber networks
653 $a Multiphoton microscopy
653 $a Biomechanical properties
690 $a 0541
690 $a 0648
690 $a 0493
690 $a 0757
710 2 $a The University of Iowa. $b Biomedical Engineering. $e degree granting institution. $3 3815364
720 1 $a Sander, Edward $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-01B.
790 $a 0096
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31239017