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Genetic and Pharmacological Factors ...

Egan, Brian M.,

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Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans // Brian M Egan.
Author:	Egan, Brian M.,
Description:	1 electronic resource (411 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-04, Section: B.
Contained By:	Dissertations Abstracts International85-04B.
Subject:	Aging. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30688909
ISBN:	9798380603409

Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans /
Egan, Brian M.,

Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans /Brian M Egan. - 1 electronic resource (411 pages)

Source: Dissertations Abstracts International, Volume: 85-04, Section: B.

Aging is a time-dependent decline in organismal structure and function that ultimately results in death. Aging occurs in nearly all metazoan organisms, and is a major risk factor for many human diseases including cancer, diabetes, hypertension, heart disease, and Alzheimer's Disease. The genetic pathways and mechanistic factors that underly the aging process are poorly understood. Control of aging in the nematode C. elegans can be accomplished via modulation of gene activity by genetic knockdown or by the introduction of inhibitory pharmaceutical compounds. While many such interventions have been described in the literature, understanding the underlying mechanisms that control aging remains a critical goal of aging research.Here, I advance the field by characterizing genetic and pharmacological mechanisms which control aging in C. elegans. Among these factors are phm-2 and eat-2, genes necessary for pharynx development and function that control aging via a unique interaction between dietary restriction and the innate immune system; the human amyloid beta peptide, the proposed causative agent of Alzheimer's Disease, which enhances survival under pathogenic stress conditions; the ACE-inhibitor drug captopril and its mechanistic target acn-1, which control aging via interaction with the molting and developmental decision making pathways, and represent a highly conserved mechanism for lifespan extension across the animal kingdom; a novel allele of the well-studied daf-2 receptor tyrosine kinase gene that recapitulates human insulin receptoropathies; and osmotic stress response to sodium chloride concentration, which highlights a previously unrecognized role in nematode culture conditions that controls aging. These discoveries further our understanding of the mechanistic basis of aging in C. elegans.

English

ISBN: 9798380603409Subjects--Topical Terms:

543123
Aging.
Subjects--Index Terms:

acn-1

Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans /
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245 1 0 $a Genetic and Pharmacological Factors Control Aging in Caenorhabditis elegans / $c Brian M Egan.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 1 electronic resource (411 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 85-04, Section: B.
500 $a Advisors: Kornfeld, Kerry Committee members: Diwan, Abhinav; True, Heather; Nonet, Michael; Faccio, Roberta.
502 $b Ph.D. $c Washington University in St. Louis $d 2023.
520 $a Aging is a time-dependent decline in organismal structure and function that ultimately results in death. Aging occurs in nearly all metazoan organisms, and is a major risk factor for many human diseases including cancer, diabetes, hypertension, heart disease, and Alzheimer's Disease. The genetic pathways and mechanistic factors that underly the aging process are poorly understood. Control of aging in the nematode C. elegans can be accomplished via modulation of gene activity by genetic knockdown or by the introduction of inhibitory pharmaceutical compounds. While many such interventions have been described in the literature, understanding the underlying mechanisms that control aging remains a critical goal of aging research.Here, I advance the field by characterizing genetic and pharmacological mechanisms which control aging in C. elegans. Among these factors are phm-2 and eat-2, genes necessary for pharynx development and function that control aging via a unique interaction between dietary restriction and the innate immune system; the human amyloid beta peptide, the proposed causative agent of Alzheimer's Disease, which enhances survival under pathogenic stress conditions; the ACE-inhibitor drug captopril and its mechanistic target acn-1, which control aging via interaction with the molting and developmental decision making pathways, and represent a highly conserved mechanism for lifespan extension across the animal kingdom; a novel allele of the well-studied daf-2 receptor tyrosine kinase gene that recapitulates human insulin receptoropathies; and osmotic stress response to sodium chloride concentration, which highlights a previously unrecognized role in nematode culture conditions that controls aging. These discoveries further our understanding of the mechanistic basis of aging in C. elegans.
546 $a English
590 $a School code: 0252
650 4 $a Aging. $3 543123
650 4 $a Developmental biology. $3 592588
650 4 $a Pharmacology. $3 634543
653 $a acn-1
653 $a C. elegans
653 $a Captopril
653 $a Dietary restriction
653 $a Longevity
690 $a 0493
690 $a 0758
690 $a 0419
710 2 $a Washington University in St. Louis. $b Biology & Biomedical Sciences (Molecular Cell Biology). $e degree granting institution. $3 3819178
720 1 $a Kornfeld, Kerry $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-04B.
790 $a 0252
791 $a Ph.D.
792 $a 2023
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30688909