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Applications of Hybrid Metaheuristic...

McCumber, Joshua A.,

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Applications of Hybrid Metaheuristic Algorithms for Optimization of Production Operations and Transportation Management in Medical Radioisotope Production /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Applications of Hybrid Metaheuristic Algorithms for Optimization of Production Operations and Transportation Management in Medical Radioisotope Production // Joshua A McCumber.
Author:	McCumber, Joshua A.,
Description:	1 electronic resource (184 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-06, Section: B.
Contained By:	Dissertations Abstracts International86-06B.
Subject:	Engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31762391
ISBN:	9798346849643

Applications of Hybrid Metaheuristic Algorithms for Optimization of Production Operations and Transportation Management in Medical Radioisotope Production /
McCumber, Joshua A.,

Applications of Hybrid Metaheuristic Algorithms for Optimization of Production Operations and Transportation Management in Medical Radioisotope Production /Joshua A McCumber. - 1 electronic resource (184 pages)

Source: Dissertations Abstracts International, Volume: 86-06, Section: B.

Particle accelerators utilized in producing medical radioisotopes are often at a competitive disadvantage to nuclear reactors for producing the neutron-abundant species currently dominating the diagnostic and therapeutic medical use landscape. Reliance on foreign supply chains for isotopes such as 99mTc has seen shortages in the previous decades, affecting the access to care for many Americans. Often confronted with competitive disadvantages, businesses have hesitated to enter this business space and are dilatory in meeting domestic production needs. The legislative drive to eliminate uranium-based targets for irradiation and production of medical radioisotopes in overseas reactors presents additional complications to the supply chain. Alternate production pathway facilities manufacturing neutron and proton-abundant isotope species may be necessary to realize these goals. Production and logistics optimization provide complex problem spaces to be examined to increase the competitiveness of particle accelerator-based production strategies. The application of metaheuristic algorithms to aid in the planning and executing the production and transportation of decaying inventories shows effective increases in cost and time savings compared to conventional planning methodologies. Regional accelerator-based production centers may bridge the gap and decrease reliance on foreign radioisotope supply chains, increasing domestic access to radiotherapy, diagnosis, and palliative care.

English

ISBN: 9798346849643Subjects--Topical Terms:

586835
Engineering.
Subjects--Index Terms:

Particle accelerators

Applications of Hybrid Metaheuristic Algorithms for Optimization of Production Operations and Transportation Management in Medical Radioisotope Production /
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245 1 0 $a Applications of Hybrid Metaheuristic Algorithms for Optimization of Production Operations and Transportation Management in Medical Radioisotope Production / $c Joshua A McCumber.
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500 $a Advisors: Bierce, Jonathan; Blackford, Joseph P. Committee members: Biemer, Steven.
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520 $a Particle accelerators utilized in producing medical radioisotopes are often at a competitive disadvantage to nuclear reactors for producing the neutron-abundant species currently dominating the diagnostic and therapeutic medical use landscape. Reliance on foreign supply chains for isotopes such as 99mTc has seen shortages in the previous decades, affecting the access to care for many Americans. Often confronted with competitive disadvantages, businesses have hesitated to enter this business space and are dilatory in meeting domestic production needs. The legislative drive to eliminate uranium-based targets for irradiation and production of medical radioisotopes in overseas reactors presents additional complications to the supply chain. Alternate production pathway facilities manufacturing neutron and proton-abundant isotope species may be necessary to realize these goals. Production and logistics optimization provide complex problem spaces to be examined to increase the competitiveness of particle accelerator-based production strategies. The application of metaheuristic algorithms to aid in the planning and executing the production and transportation of decaying inventories shows effective increases in cost and time savings compared to conventional planning methodologies. Regional accelerator-based production centers may bridge the gap and decrease reliance on foreign radioisotope supply chains, increasing domestic access to radiotherapy, diagnosis, and palliative care.
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650 4 $a Mathematics. $3 515831
650 4 $a Nuclear physics. $3 517741
650 4 $a Medicine. $3 641104
650 4 $a Health sciences. $3 3168359
653 $a Particle accelerators
653 $a Nuclear reactors
653 $a Metaheuristic algorithms
653 $a Foreign radioisotope supply chains
653 $a Radiotherapy
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710 2 $a The George Washington University. $b Engineering Management. $e degree granting institution. $3 3770547
720 1 $a Bierce, Jonathan $e degree supervisor.
720 1 $a Blackford, Joseph P. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-06B.
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