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Thyroid Hormone-Informed Patterning ...

Autumn, Melody Anastasia Sabrina,

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Thyroid Hormone-Informed Patterning and Remembered Positional Identity Direct Zebrafish Fin Ray Morphology /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Thyroid Hormone-Informed Patterning and Remembered Positional Identity Direct Zebrafish Fin Ray Morphology // Melody Anastasia Sabrina Autumn.
Author:	Autumn, Melody Anastasia Sabrina,
Description:	1 electronic resource (154 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-06, Section: B.
Contained By:	Dissertations Abstracts International86-06B.
Subject:	Biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31639290
ISBN:	9798346760825

Thyroid Hormone-Informed Patterning and Remembered Positional Identity Direct Zebrafish Fin Ray Morphology /
Autumn, Melody Anastasia Sabrina,

Thyroid Hormone-Informed Patterning and Remembered Positional Identity Direct Zebrafish Fin Ray Morphology /Melody Anastasia Sabrina Autumn. - 1 electronic resource (154 pages)

Source: Dissertations Abstracts International, Volume: 86-06, Section: B.

Resolving the mechanisms that orchestrate patterning in complex tissues - particularly how positional identity is instantiated, remembered, and directed - is imperative to understanding the morphogenesis of appendages. The zebrafish (Danio rerio) caudal fin skeleton is a powerful model to investigate these questions, as its precisely patterned bony fin rays are restored through regeneration. My aims in this thesis were to investigate the role of endocrine metabolic regulator thyroid hormone (TH) signaling during fin ray morphogenesis and how spatial identity is retained and redeployed during regeneration. I began my work by resolving TH signaling effects on the fin skeleton. Through nuclear receptor Thrab, TH acutely induces distal features in both development and regeneration (Chapter 2). To better understand how distal features are remembered, I established novel microsurgery techniques that would discriminate autonomous versus environmental components of ray patterning. While the rate of regeneration does appear to retain positional memory, I found ray patterning is instead informed by extrinsic cues (Chapter 3). During my investigation of TH activity in Chapter 2, I noted robust TH signaling in peripheral rays. Repurposing the microsurgeries developed in Chapter 3, I discovered this TH signaling is an inherent feature of peripheral rays, and this activity regulates local Notch pathway signaling (Chapter 4). My research has revealed many mechanisms-both dependent and independent of TH-that regulate fin ray patterning and how this positional identity is retained and redeployed during regeneration.

English

ISBN: 9798346760825Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Patterning

Thyroid Hormone-Informed Patterning and Remembered Positional Identity Direct Zebrafish Fin Ray Morphology /
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245 1 0 $a Thyroid Hormone-Informed Patterning and Remembered Positional Identity Direct Zebrafish Fin Ray Morphology / $c Melody Anastasia Sabrina Autumn.
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500 $a Advisors: McMenamin, Sarah K.; Folker, Eric Committee members: Losick, Vicki; Gonzalez Rosa, Juan Manuel; Harris, Matthew.
502 $b Ph.D. $c Boston College $d 2024.
520 $a Resolving the mechanisms that orchestrate patterning in complex tissues - particularly how positional identity is instantiated, remembered, and directed - is imperative to understanding the morphogenesis of appendages. The zebrafish (Danio rerio) caudal fin skeleton is a powerful model to investigate these questions, as its precisely patterned bony fin rays are restored through regeneration. My aims in this thesis were to investigate the role of endocrine metabolic regulator thyroid hormone (TH) signaling during fin ray morphogenesis and how spatial identity is retained and redeployed during regeneration. I began my work by resolving TH signaling effects on the fin skeleton. Through nuclear receptor Thrab, TH acutely induces distal features in both development and regeneration (Chapter 2). To better understand how distal features are remembered, I established novel microsurgery techniques that would discriminate autonomous versus environmental components of ray patterning. While the rate of regeneration does appear to retain positional memory, I found ray patterning is instead informed by extrinsic cues (Chapter 3). During my investigation of TH activity in Chapter 2, I noted robust TH signaling in peripheral rays. Repurposing the microsurgeries developed in Chapter 3, I discovered this TH signaling is an inherent feature of peripheral rays, and this activity regulates local Notch pathway signaling (Chapter 4). My research has revealed many mechanisms-both dependent and independent of TH-that regulate fin ray patterning and how this positional identity is retained and redeployed during regeneration.
546 $a English
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650 4 $a Biology. $3 522710
650 4 $a Aquatic sciences. $3 3174300
650 4 $a Developmental biology. $3 592588
650 4 $a Endocrinology. $3 610914
653 $a Patterning
653 $a Regeneration
653 $a Thyroid hormone
653 $a Zebrafish
690 $a 0306
690 $a 0409
690 $a 0758
690 $a 0792
710 2 $a Boston College. $b GSAS - Biology. $e degree granting institution. $3 3816996
720 1 $a McMenamin, Sarah K. $e degree supervisor.
720 1 $a Folker, Eric $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-06B.
790 $a 0016
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31639290