東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The Impact of the Menstrual Cycle an...

Lew, Lindsay A.,

Linked to FindBook

Google Book

Amazon

博客來

The Impact of the Menstrual Cycle and Hormonal Contraceptives on Cardiovascular Function in Premenopausal Females /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Impact of the Menstrual Cycle and Hormonal Contraceptives on Cardiovascular Function in Premenopausal Females // Lindsay A Lew.
Author:	Lew, Lindsay A.,
Description:	1 electronic resource (224 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
Contained By:	Dissertations Abstracts International86-07B.
Subject:	Physiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31822498
ISBN:	9798302368683

The Impact of the Menstrual Cycle and Hormonal Contraceptives on Cardiovascular Function in Premenopausal Females /
Lew, Lindsay A.,

The Impact of the Menstrual Cycle and Hormonal Contraceptives on Cardiovascular Function in Premenopausal Females /Lindsay A Lew. - 1 electronic resource (224 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

Premenopausal females can experience fluctuations in endogenous and synthetic sex hormones, estrogen and progesterone. Exposure to fluctuations in endogenous estrogen and progesterone occurs across the menstrual cycle, while exposure to synthetic forms of estrogen and progesterone occur with the use of hormonal contraceptives, such as oral contraceptive pills and intrauterine devices. Endothelial function and muscle sympathetic nerve activity are two important indices of cardiovascular function and health which may be influenced by sex hormones. However, there are still many limitations to our understanding of the impact of menstrual phase and hormonal contraceptives on these key indices of cardiovascular function. To address gaps in the literature, this dissertation examined: 1) the mechanisms influencing endothelial function across the menstrual cycle; 2) the repeatability of the impact of oral contraceptive pill phase on endothelial function across two cycles; 3) the influence of an acute shear stress pattern insult to endothelial function in oral contraceptive pill users; and 4) the impact of muscle sympathetic nerve activity and blood pressure regulation during an exercise stressor in oral contraceptive pill users compared to intrauterine device users. The primary findings of this dissertation were: 1) menstrual phase did not alter endothelial function or estrogen-related proteins; 2) oral contraceptive pill users experienced consistent impairments in endothelial function during periods of synthetic hormone exposure across two cycles at the group level but not at the individual level; 3) an acute shear stress pattern insult impaired endothelial function in oral contraceptive pill users, regardless of pill phase; and 4) muscle sympathetic nerve activity and blood pressure responses to an exercise stressor were not different between two types of hormonal contraceptive users. These findings of this dissertation advance our understanding of the impact of endogenous and synthetic sex hormone exposure via the menstrual cycle and hormonal contraceptive use on fundamental components of cardiovascular physiology and health.

English

ISBN: 9798302368683Subjects--Topical Terms:

518431
Physiology.

The Impact of the Menstrual Cycle and Hormonal Contraceptives on Cardiovascular Function in Premenopausal Females /
LDR:03495nmm a22004213i 4500 001 2429121
005 20250428055609.5
006 m o d
007 cr|nu||||||||
008 261011s2024 miu||||||m |||||||eng d
020 $a 9798302368683
035 $a (MiAaPQD)AAI31822498
035 $a AAI31822498
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Lew, Lindsay A., $e author. $3 3816780
245 1 0 $a The Impact of the Menstrual Cycle and Hormonal Contraceptives on Cardiovascular Function in Premenopausal Females / $c Lindsay A Lew.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (224 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
500 $a Advisors: Pyke, Kyra Ellen.
502 $b Ph.D. $c Queen's University (Canada) $d 2024.
520 $a Premenopausal females can experience fluctuations in endogenous and synthetic sex hormones, estrogen and progesterone. Exposure to fluctuations in endogenous estrogen and progesterone occurs across the menstrual cycle, while exposure to synthetic forms of estrogen and progesterone occur with the use of hormonal contraceptives, such as oral contraceptive pills and intrauterine devices. Endothelial function and muscle sympathetic nerve activity are two important indices of cardiovascular function and health which may be influenced by sex hormones. However, there are still many limitations to our understanding of the impact of menstrual phase and hormonal contraceptives on these key indices of cardiovascular function. To address gaps in the literature, this dissertation examined: 1) the mechanisms influencing endothelial function across the menstrual cycle; 2) the repeatability of the impact of oral contraceptive pill phase on endothelial function across two cycles; 3) the influence of an acute shear stress pattern insult to endothelial function in oral contraceptive pill users; and 4) the impact of muscle sympathetic nerve activity and blood pressure regulation during an exercise stressor in oral contraceptive pill users compared to intrauterine device users. The primary findings of this dissertation were: 1) menstrual phase did not alter endothelial function or estrogen-related proteins; 2) oral contraceptive pill users experienced consistent impairments in endothelial function during periods of synthetic hormone exposure across two cycles at the group level but not at the individual level; 3) an acute shear stress pattern insult impaired endothelial function in oral contraceptive pill users, regardless of pill phase; and 4) muscle sympathetic nerve activity and blood pressure responses to an exercise stressor were not different between two types of hormonal contraceptive users. These findings of this dissertation advance our understanding of the impact of endogenous and synthetic sex hormone exposure via the menstrual cycle and hormonal contraceptive use on fundamental components of cardiovascular physiology and health.
546 $a English
590 $a School code: 0283
650 4 $a Physiology. $3 518431
650 4 $a Exercise. $3 532868
650 4 $a Hormones. $3 548778
650 4 $a Physical fitness. $3 522279
650 4 $a Investigations. $3 3561159
650 4 $a Cardiovascular system. $3 783051
650 4 $a Atherosclerosis. $3 862934
650 4 $a Birth control. $3 665395
650 4 $a Oxidative stress. $3 899116
650 4 $a Blood pressure. $3 661055
650 4 $a Menstruation. $3 606309
650 4 $a Steroids. $3 697464
650 4 $a Intrauterine devices--IUD. $3 3816781
650 4 $a Endothelium. $3 1898152
650 4 $a Cardiovascular disease. $3 3564561
650 4 $a Hemodynamics. $3 695992
650 4 $a Nitric oxide. $3 750512
650 4 $a Heart. $3 578987
650 4 $a Endocrinology. $3 610914
650 4 $a Kinesiology. $3 517627
650 4 $a Medicine. $3 641104
650 4 $a Morphology. $3 591167
650 4 $a Obstetrics. $3 634501
650 4 $a Public health. $3 534748
690 $a 0719
690 $a 0409
690 $a 0575
690 $a 0564
690 $a 0287
690 $a 0380
690 $a 0573
710 2 $a Queen's University (Canada). $e degree granting institution. $3 3765623
720 1 $a Pyke, Kyra Ellen $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-07B.
790 $a 0283
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31822498