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Application of Upconverting Nanopart...

Rappeport, Eric,

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Application of Upconverting Nanoparticles and Gold Nanorods for Biomedical Sensing and Detection /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Application of Upconverting Nanoparticles and Gold Nanorods for Biomedical Sensing and Detection // Eric Rappeport.
Author:	Rappeport, Eric,
Description:	1 electronic resource (95 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
Contained By:	Dissertations Abstracts International85-03B.
Subject:	Nanoscience. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30631146
ISBN:	9798380167789

Application of Upconverting Nanoparticles and Gold Nanorods for Biomedical Sensing and Detection /
Rappeport, Eric,

Application of Upconverting Nanoparticles and Gold Nanorods for Biomedical Sensing and Detection /Eric Rappeport. - 1 electronic resource (95 pages)

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

Nanoparticles are organized structures that exist on scales between the molecular and cellular levels. They are being intensively studied in a variety of fields for their potential to overcome the limitations of traditional materials. In particular, inorganic nanoparticles such as rare-earth doped, upconverting nanoparticles (UCNPs) and gold nanorods (AuNRs) are being investigated as the next generation of biological optical sensors, as well as potential therapeutic agents. This thesis summarizes the work that I have done in the synthesis, design, fabrication, and implementation of UCNPs and AuNRs towards biological applications. It covers how to make both UCNPs and AuNRs, and also explains how to conjugate them with molecular species such as optical dyes or antibodies. Using a nanoparticle system consisting of a Tm3+-doped UCNP conjugated to the pH sensitive fluorescent dye FITC, my colleagues and I were able to demonstrate optical, ratiometric sensing of pH. Similarly, we were able to conjugate Er3+-doped UCNPs and AuNRs with the commercial antibody C225 to target bladder cancer cells and tumors. Irradiation of the C225-conjugated UCNPs with 980 nm light allowed the specific, optical detection of cancerous cells, while irradiation with 808 nm light led to observed cell death due to photothermal damage caused by the AuNRs. This combination of imaging and therapeutic capabilities makes these C225-conjugation nanoparticles very promising for future cancer treatments.

English

ISBN: 9798380167789Subjects--Topical Terms:

587832
Nanoscience.
Subjects--Index Terms:

Imaging

Application of Upconverting Nanoparticles and Gold Nanorods for Biomedical Sensing and Detection /
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100 1 $a Rappeport, Eric, $e author. $3 3816083
245 1 0 $a Application of Upconverting Nanoparticles and Gold Nanorods for Biomedical Sensing and Detection / $c Eric Rappeport.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 1 electronic resource (95 pages)
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500 $a Advisors: Park, Won Committee members: Cogswell, Carol; Shaheen, Sean; Goodwin, Andrew; Moddel, Garret.
502 $b Ph.D. $c University of Colorado at Boulder $d 2023.
520 $a Nanoparticles are organized structures that exist on scales between the molecular and cellular levels. They are being intensively studied in a variety of fields for their potential to overcome the limitations of traditional materials. In particular, inorganic nanoparticles such as rare-earth doped, upconverting nanoparticles (UCNPs) and gold nanorods (AuNRs) are being investigated as the next generation of biological optical sensors, as well as potential therapeutic agents. This thesis summarizes the work that I have done in the synthesis, design, fabrication, and implementation of UCNPs and AuNRs towards biological applications. It covers how to make both UCNPs and AuNRs, and also explains how to conjugate them with molecular species such as optical dyes or antibodies. Using a nanoparticle system consisting of a Tm3+-doped UCNP conjugated to the pH sensitive fluorescent dye FITC, my colleagues and I were able to demonstrate optical, ratiometric sensing of pH. Similarly, we were able to conjugate Er3+-doped UCNPs and AuNRs with the commercial antibody C225 to target bladder cancer cells and tumors. Irradiation of the C225-conjugated UCNPs with 980 nm light allowed the specific, optical detection of cancerous cells, while irradiation with 808 nm light led to observed cell death due to photothermal damage caused by the AuNRs. This combination of imaging and therapeutic capabilities makes these C225-conjugation nanoparticles very promising for future cancer treatments.
546 $a English
590 $a School code: 0051
650 4 $a Nanoscience. $3 587832
650 4 $a Materials science. $3 543314
650 4 $a Biomedical engineering. $3 535387
650 4 $a Oncology. $3 751006
653 $a Imaging
653 $a Nanoparticles
653 $a Nanorods
653 $a Photothermal damage
653 $a Molecular species
690 $a 0565
690 $a 0794
690 $a 0992
690 $a 0541
710 2 $a University of Colorado at Boulder. $b Electrical Engineering. $e degree granting institution. $3 3816084
720 1 $a Park, Won $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-03B.
790 $a 0051
791 $a Ph.D.
792 $a 2023
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30631146