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Studies in Radical-Mediated Trifluor...

Zhao, Tongyun,

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Studies in Radical-Mediated Trifluoromethyl-Difunctionalization Reactions /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Studies in Radical-Mediated Trifluoromethyl-Difunctionalization Reactions // Tongyun Zhao.
作者:	Zhao, Tongyun,
面頁冊數:	1 electronic resource (239 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
Contained By:	Dissertations Abstracts International86-07B.
標題:	Organic chemistry. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31767300
ISBN:	9798302182593

Studies in Radical-Mediated Trifluoromethyl-Difunctionalization Reactions /
Zhao, Tongyun,

Studies in Radical-Mediated Trifluoromethyl-Difunctionalization Reactions /Tongyun Zhao. - 1 electronic resource (239 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

Trifluoromethylated compounds hold significant importance in medicinal and material sciences due to their unique physicochemical properties. Consequently, numerous methodologies have been developed to achieve the selective incorporation of trifluoromethyl groups. Among the existing methods to construct C-CF3 bonds, radical trifluoromethylation reactions have received much attention due to their high reactivity, mild reaction condition, and broad substrate scope. With the assistance of a novel trifluoromethylated Cu(III) complex, we have first achieved a radical (bis)trifluoromethylation-cyclization reaction of 1,6-enyne substrates to construct complex hexafluorinated pyrrolidine and piperidine-derived skeleton in one step reaction. Except for the copper catalyzed (bis)trifluoromethylation, a trifluoromethylarylation reaction applying nickel/photoredox dual catalyst system was also developed. The reaction scope was proved to be ubiquitous, offering difunctionalization products across a wide variety of unsaturated moieties.

English

ISBN: 9798302182593Subjects--Topical Terms:

523952
Organic chemistry.
Subjects--Index Terms:

Trifluoromethylated compounds

Studies in Radical-Mediated Trifluoromethyl-Difunctionalization Reactions /
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