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Medicines, Metabolites, and Pigments...

Crum, Alexandra Hazel,

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Medicines, Metabolites, and Pigments in Caryophyllales and Beyond /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Medicines, Metabolites, and Pigments in Caryophyllales and Beyond // Alexandra Hazel Crum.
Author:	Crum, Alexandra Hazel,
Description:	1 electronic resource (161 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
Contained By:	Dissertations Abstracts International86-03B.
Subject:	Botany. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31327584
ISBN:	9798384097426

Medicines, Metabolites, and Pigments in Caryophyllales and Beyond /
Crum, Alexandra Hazel,

Medicines, Metabolites, and Pigments in Caryophyllales and Beyond /Alexandra Hazel Crum. - 1 electronic resource (161 pages)

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

Premise-Better understanding of the relationship between plant specialized metabolism and traditional medicine has the potential to aid in bioprospecting and untangling of crosscultural use patterns. However, given the limited information available for metabolites in most plant species, understanding medicinal use-metabolite relationships can be difficult. The order Caryophyllales has a unique pattern of lineages of tyrosine- or phenylalanine-dominated specialized metabolism, represented by mutually exclusive anthocyanin and betalain pigments, making Caryophyllales a compelling system to explore the relationship between medicine and metabolites by using pigment as a proxy for dominant metabolism.Methods-We compiled a list of medicinal species in select tyrosine- or phenylalanine-dominant families of Caryophyllales (Nepenthaceae, Polygonaceae, Simmondsiaceae, Microteaceae, Caryophyllaceae, Amaranthaceae, Limeaceae, Molluginaceae, Portulacaceae, Cactaceae, and Nyctaginaceae) by searching scientific literature until no new uses were recovered. We then tested for phylogenetic clustering of uses using a "hot nodes" approach. To test potential nonmetabolite drivers of medicinal use, like how often humans encounter a species (apparency), we repeated the analysis using only North American species across the entire order and performed phylogenetic generalized least squares regression (PGLS) with occurrence data from the Global Biodiversity Information Facility (GBIF).Key Results-We hypothesized families with tyrosine-enriched metabolism would show clustering of different types of medicinal use compared to phenylalanine-enriched metabolism. Instead, wide-ranging, apparent clades in Polygonaceae and Amaranthaceae are overrepresented across nearly all types of medicinal use.Conclusions-Our results suggest that apparency is a better predictor of medicinal use than metabolism, although metabolism type may still be a contributing factor.

English

ISBN: 9798384097426Subjects--Topical Terms:

516217
Botany.
Subjects--Index Terms:

Anthocyanin

Medicines, Metabolites, and Pigments in Caryophyllales and Beyond /
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245 1 0 $a Medicines, Metabolites, and Pigments in Caryophyllales and Beyond / $c Alexandra Hazel Crum.
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500 $a Advisors: Yang, Ya Committee members: Carter, Clay; Hegeman, Adrian; Philander, Lisa.
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520 $a Premise-Better understanding of the relationship between plant specialized metabolism and traditional medicine has the potential to aid in bioprospecting and untangling of crosscultural use patterns. However, given the limited information available for metabolites in most plant species, understanding medicinal use-metabolite relationships can be difficult. The order Caryophyllales has a unique pattern of lineages of tyrosine- or phenylalanine-dominated specialized metabolism, represented by mutually exclusive anthocyanin and betalain pigments, making Caryophyllales a compelling system to explore the relationship between medicine and metabolites by using pigment as a proxy for dominant metabolism.Methods-We compiled a list of medicinal species in select tyrosine- or phenylalanine-dominant families of Caryophyllales (Nepenthaceae, Polygonaceae, Simmondsiaceae, Microteaceae, Caryophyllaceae, Amaranthaceae, Limeaceae, Molluginaceae, Portulacaceae, Cactaceae, and Nyctaginaceae) by searching scientific literature until no new uses were recovered. We then tested for phylogenetic clustering of uses using a "hot nodes" approach. To test potential nonmetabolite drivers of medicinal use, like how often humans encounter a species (apparency), we repeated the analysis using only North American species across the entire order and performed phylogenetic generalized least squares regression (PGLS) with occurrence data from the Global Biodiversity Information Facility (GBIF).Key Results-We hypothesized families with tyrosine-enriched metabolism would show clustering of different types of medicinal use compared to phenylalanine-enriched metabolism. Instead, wide-ranging, apparent clades in Polygonaceae and Amaranthaceae are overrepresented across nearly all types of medicinal use.Conclusions-Our results suggest that apparency is a better predictor of medicinal use than metabolism, although metabolism type may still be a contributing factor.
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650 4 $a Pharmacology. $3 634543
650 4 $a Plant sciences. $3 3173832
650 4 $a Medicine. $3 641104
650 4 $a Bioinformatics. $3 553671
653 $a Anthocyanin
653 $a Betalain
653 $a Caryophyllales
653 $a Ethnobotany
653 $a Hmong
653 $a Specialized metabolism
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690 $a 0479
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690 $a 0715
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