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Nanofiber-Hydrogel Composite Scaffol...

Carter, Jacob Lee,

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Nanofiber-Hydrogel Composite Scaffold Fabrication Methods for Peripheral Nerve Regeneration /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Nanofiber-Hydrogel Composite Scaffold Fabrication Methods for Peripheral Nerve Regeneration // Jacob Lee Carter.
Author:	Carter, Jacob Lee,
Description:	1 electronic resource (119 pages)
Notes:	Source: Masters Abstracts International, Volume: 86-03.
Contained By:	Masters Abstracts International86-03.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31561278
ISBN:	9798384104230

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods for Peripheral Nerve Regeneration /
Carter, Jacob Lee,

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods for Peripheral Nerve Regeneration /Jacob Lee Carter. - 1 electronic resource (119 pages)

Source: Masters Abstracts International, Volume: 86-03.

Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A second method where individual films of fibers embedded in hydrogel were rolled was developed, introducing void space throughout the scaffold that allows for easier cell infiltration. The final method uses a sacrificial hydrogel scaffold template to manufacture the scaffold. The desired hydrogel is infiltrated into the template hydrogel and crosslinked before the template's removal, allowing for a much wider variety of hydrogels such as pH or ion responsive materials. It was found that GelMe and hyaluronic acid-based hydrogels limited axon infiltration in a sciatic nerve gap model at the studied weight percent and degrees of crosslinking. This result highlights how the infiltration manufacturing approach may be critical for fabricating aligned nanofiber-hydrogel composite grafts from next generation hydrogels.

English

ISBN: 9798384104230Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Fabrication

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods for Peripheral Nerve Regeneration /
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100 1 $a Carter, Jacob Lee, $e author. $3 3815697
245 1 0 $a Nanofiber-Hydrogel Composite Scaffold Fabrication Methods for Peripheral Nerve Regeneration / $c Jacob Lee Carter.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (119 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Masters Abstracts International, Volume: 86-03.
500 $a Advisors: Beachley, Vince Committee members: Vega, Sebastian; Fuller, David.
502 $b M.S. $c Rowan University $d 2024.
520 $a Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A second method where individual films of fibers embedded in hydrogel were rolled was developed, introducing void space throughout the scaffold that allows for easier cell infiltration. The final method uses a sacrificial hydrogel scaffold template to manufacture the scaffold. The desired hydrogel is infiltrated into the template hydrogel and crosslinked before the template's removal, allowing for a much wider variety of hydrogels such as pH or ion responsive materials. It was found that GelMe and hyaluronic acid-based hydrogels limited axon infiltration in a sciatic nerve gap model at the studied weight percent and degrees of crosslinking. This result highlights how the infiltration manufacturing approach may be critical for fabricating aligned nanofiber-hydrogel composite grafts from next generation hydrogels.
546 $a English
590 $a School code: 1419
650 4 $a Biomedical engineering. $3 535387
650 4 $a Industrial engineering. $3 526216
650 4 $a Nanoscience. $3 587832
653 $a Fabrication
653 $a Hydrogels
653 $a Nanofibers
653 $a Nerve graft conduits
653 $a Additive manufacturing
690 $a 0541
690 $a 0565
690 $a 0546
710 2 $a Rowan University. $b Biomedical Engineering. $e degree granting institution. $3 3815698
720 1 $a Beachley, Vince $e degree supervisor.
773 0 $t Masters Abstracts International $g 86-03.
790 $a 1419
791 $a M.S.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31561278