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Biochemical and molecular pharmacolo...

Rudrapal, Mithun.

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Biochemical and molecular pharmacology in drug discovery /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Biochemical and molecular pharmacology in drug discovery // edited by Mithun Rudrapal, Chukwuebuka Egbuna and William C. Cho.
other author:	Rudrapal, Mithun.
Published:	Amsterdam, Netherlands :Elsevier, : c2024.,
Description:	xiv, 565 p. :ill. (some col.) ;24 cm.
[NT 15003449]:	Front Cover -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- Copyright -- Contents -- Contributors -- I -- Biochemical and molecular aspects -- 1 -- Structures and functions of biomolecules -- 1. Introduction -- 1.1 About biomolecules -- 1.2 Carbohydrates -- 1.2.1 Structure of carbohydrates -- 1.2.2 Functions of carbohydrates -- 1.3 Proteins -- 1.3.1 Structure of proteins -- 1.3.2 Functions of proteins -- 1.4 Lipids -- 1.4.1 Structure of lipids -- 1.4.2 Functions of lipids -- 1.5 Nucleic acids
[NT 15003449]:	1.5.1 Structure of nucleic acids -- 1.5.1.1 Types of RNA -- 1.5.2 Functions of nucleic acids -- 2. Structure Activity Relationship (SAR) -- 2.1 Need for the SAR study -- 3. Ligands -- 3.1 Classification of ligands -- 4. Receptors -- 4.1 Classification of receptors -- 4.2 Some of the examples of the receptors acting as therapeutic targets -- 5. Conclusion -- References -- 2 -- Pharmacokinetics and pharmacodynamics -- 1. Introduction -- 1.1 Sources of drugs -- 1.2 Drug nomenclature -- 1.3 Drug classification -- 1.4 Drug transport through cell membranes -- 1.4.1 Simple diffusion -- 1.4.2 Filtration
[NT 15003449]:	1.4.3 Carrier mediated -- 1.4.4 Endocytosis -- 2. Pharmacokinetics (ADME) -- 2.1 Absorption -- 2.1.1 Bioavailability -- 2.1.1.1 Factors affecting oral bioavailability -- 2.1.2 Factors influencing digestive resorption -- 2.1.2.1 Pharmaceutical form -- 2.1.2.2 pH, PKa, log P, molecular weight -- 2.1.2.3 Metabolism in the digestive tract, gastric secretion and food bowl -- 2.1.2.4 First pass effect -- 2.1.2.5 Other factors -- 2.2 Distribution -- 2.2.1 Patterns of distribution -- 2.2.2 Factors affecting distribution of drugs -- 2.2.3 Apparent volume of distribution (Vd)
[NT 15003449]:	2.3 Metabolism (biotransformation) -- 2.3.1 Site of metabolism -- 2.3.2 Types of metabolic reactions -- 2.3.3 Enzymes responsible for biotransformation -- 2.3.4 Factors affecting hepatic microsomal enzyme activity -- 2.4 Excretion -- 2.4.1 Clearance -- 2.5 Fundamental principles of pharmacokinetics -- 2.5.1 Plasma half-life (t1/2) -- 2.5.2 Loading dose -- 2.5.3 Maintenance dose -- 2.5.4 Methods used to prolong duration of action of drugs -- 3. Pharmacodynamics -- 3.1 Possible mechanisms of action of drugs -- 3.2 Definition of receptors -- 3.3 Affinity -- 3.4 Efficacy -- 3.5 Potency
[NT 15003449]:	3.6 The amount of response -- 3.7 Relation between concentration and response -- 3.7.1 Dose-response curve of drugs -- 3.7.2 Types of ligands -- 3.7.3 Types of antagonists -- 3.7.4 Non-competitive block types -- 3.7.5 Types of receptors and signal transduction mechanism -- 4. Conclusion -- References -- 3 -- Overview of drugs and drug targets -- 1. Introduction -- 1.1 Drug development process -- 1.2 Discovery -- 1.2.1 Target identification and validation -- 1.2.2 Assay development -- 1.2.3 Lead identification -- 1.2.4 Lead optimization -- 1.3 Development -- 1.3.1 Predevelopment
Subject:	Pharmacology. -
ISBN:	9780443160134

Biochemical and molecular pharmacology in drug discovery /
Biochemical and molecular pharmacology in drug discovery /edited by Mithun Rudrapal, Chukwuebuka Egbuna and William C. Cho. - Amsterdam, Netherlands :Elsevier,c2024. - xiv, 565 p. :ill. (some col.) ;24 cm. - Drug Discovery Update Series. - Drug Discovery Update Series..

Includes bibliographical references and index.

Front Cover -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- Copyright -- Contents -- Contributors -- I -- Biochemical and molecular aspects -- 1 -- Structures and functions of biomolecules -- 1. Introduction -- 1.1 About biomolecules -- 1.2 Carbohydrates -- 1.2.1 Structure of carbohydrates -- 1.2.2 Functions of carbohydrates -- 1.3 Proteins -- 1.3.1 Structure of proteins -- 1.3.2 Functions of proteins -- 1.4 Lipids -- 1.4.1 Structure of lipids -- 1.4.2 Functions of lipids -- 1.5 Nucleic acids

ISBN: 9780443160134US225Subjects--Topical Terms:

3812591
Pharmacology.

LC Class. No.: RM300

Dewey Class. No.: 615.1

Biochemical and molecular pharmacology in drug discovery /
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050 # 4 $a RM300
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245 0 0 $a Biochemical and molecular pharmacology in drug discovery / $c edited by Mithun Rudrapal, Chukwuebuka Egbuna and William C. Cho.
260 # $a Amsterdam, Netherlands : $b Elsevier, $c c2024.
300 $a xiv, 565 p. : $b ill. (some col.) ; $c 24 cm.
490 0 1 $a Drug Discovery Update Series
504 $a Includes bibliographical references and index.
505 0 # $a Front Cover -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- Copyright -- Contents -- Contributors -- I -- Biochemical and molecular aspects -- 1 -- Structures and functions of biomolecules -- 1. Introduction -- 1.1 About biomolecules -- 1.2 Carbohydrates -- 1.2.1 Structure of carbohydrates -- 1.2.2 Functions of carbohydrates -- 1.3 Proteins -- 1.3.1 Structure of proteins -- 1.3.2 Functions of proteins -- 1.4 Lipids -- 1.4.1 Structure of lipids -- 1.4.2 Functions of lipids -- 1.5 Nucleic acids
505 8 # $a 1.5.1 Structure of nucleic acids -- 1.5.1.1 Types of RNA -- 1.5.2 Functions of nucleic acids -- 2. Structure Activity Relationship (SAR) -- 2.1 Need for the SAR study -- 3. Ligands -- 3.1 Classification of ligands -- 4. Receptors -- 4.1 Classification of receptors -- 4.2 Some of the examples of the receptors acting as therapeutic targets -- 5. Conclusion -- References -- 2 -- Pharmacokinetics and pharmacodynamics -- 1. Introduction -- 1.1 Sources of drugs -- 1.2 Drug nomenclature -- 1.3 Drug classification -- 1.4 Drug transport through cell membranes -- 1.4.1 Simple diffusion -- 1.4.2 Filtration
505 8 # $a 1.4.3 Carrier mediated -- 1.4.4 Endocytosis -- 2. Pharmacokinetics (ADME) -- 2.1 Absorption -- 2.1.1 Bioavailability -- 2.1.1.1 Factors affecting oral bioavailability -- 2.1.2 Factors influencing digestive resorption -- 2.1.2.1 Pharmaceutical form -- 2.1.2.2 pH, PKa, log P, molecular weight -- 2.1.2.3 Metabolism in the digestive tract, gastric secretion and food bowl -- 2.1.2.4 First pass effect -- 2.1.2.5 Other factors -- 2.2 Distribution -- 2.2.1 Patterns of distribution -- 2.2.2 Factors affecting distribution of drugs -- 2.2.3 Apparent volume of distribution (Vd)
505 8 # $a 2.3 Metabolism (biotransformation) -- 2.3.1 Site of metabolism -- 2.3.2 Types of metabolic reactions -- 2.3.3 Enzymes responsible for biotransformation -- 2.3.4 Factors affecting hepatic microsomal enzyme activity -- 2.4 Excretion -- 2.4.1 Clearance -- 2.5 Fundamental principles of pharmacokinetics -- 2.5.1 Plasma half-life (t1/2) -- 2.5.2 Loading dose -- 2.5.3 Maintenance dose -- 2.5.4 Methods used to prolong duration of action of drugs -- 3. Pharmacodynamics -- 3.1 Possible mechanisms of action of drugs -- 3.2 Definition of receptors -- 3.3 Affinity -- 3.4 Efficacy -- 3.5 Potency
505 8 # $a 3.6 The amount of response -- 3.7 Relation between concentration and response -- 3.7.1 Dose-response curve of drugs -- 3.7.2 Types of ligands -- 3.7.3 Types of antagonists -- 3.7.4 Non-competitive block types -- 3.7.5 Types of receptors and signal transduction mechanism -- 4. Conclusion -- References -- 3 -- Overview of drugs and drug targets -- 1. Introduction -- 1.1 Drug development process -- 1.2 Discovery -- 1.2.1 Target identification and validation -- 1.2.2 Assay development -- 1.2.3 Lead identification -- 1.2.4 Lead optimization -- 1.3 Development -- 1.3.1 Predevelopment
650 # 0 $a Pharmacology. $3 3812591
650 # 0 $a Molecular pharmacology. $3 736588
700 1 # $a Rudrapal, Mithun. $3 3812587
700 1 # $a Egbuna, Chukwuebuka. $3 3812588
700 1 # $a Cho, William C. $3 3812589
830 0 $a Drug Discovery Update Series. $3 3812590