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Personalized drug screening for func...

El-Khoury, Victoria.

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Personalized drug screening for functional tumor profiling

Record Type:	Electronic resources : Monograph/item
Title/Author:	Personalized drug screening for functional tumor profiling/ Victoria El-Khoury .. [et al.].
other author:	El-Khoury, Victoria.
Published:	Cambridge :Cambridge University Press, : 2022.,
Description:	22 p. :ill., digital ;23 cm.
Notes:	Title from publisher's bibliographic system (viewed on 10 Jun 2022).
Subject:	Cancer - Chemotherapy. -
Online resource:	https://doi.org/10.1017/9781009037877
ISBN:	9781009037877

Personalized drug screening for functional tumor profiling
Personalized drug screening for functional tumor profiling[electronic resource] /Victoria El-Khoury .. [et al.]. - Cambridge :Cambridge University Press,2022. - 22 p. :ill., digital ;23 cm. - Cambridge elements. Elements in Molecular Oncology,2634-7490. - Cambridge elements.Elements in Molecular Oncology..

Title from publisher's bibliographic system (viewed on 10 Jun 2022).

Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology.

ISBN: 9781009037877Subjects--Topical Terms:

753516
Cancer
--Chemotherapy.

LC Class. No.: RC271.C5

Dewey Class. No.: 616.994061

National Library of Medicine Call No.: QZ 267

Personalized drug screening for functional tumor profiling
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500 $a Title from publisher's bibliographic system (viewed on 10 Jun 2022).
520 $a Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology.
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