東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

Development of mirror-image VHHs with less immunogenicity

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of mirror-image VHHs with less immunogenicity/ by Keisuke Aoki.
作者:	Aoki, Keisuke.
出版者:	Singapore :Springer Nature Singapore : : 2025.,
面頁冊數:	xi, 116 p. :ill. (some col.), digital ;24 cm.
附註:	"Doctoral thesis accepted by Kyoto University, Kyoto, Japan."
內容註:	Chapter 1.Introduction -- Chapter 2.Chemical Synthesis of Mirror-Image VHHs and Evaluation of Their Immunogenicity -- Chapter 3.Identification of a Mirror-Image VHH against Vascular Endothelial Growth Factor -- Chapter 4.Synthetic Study of Full-Length Hepatitis B Virus Core Protein and Its Capsid Assembly -- Chapter 5.Chemical Synthesis of Interleukin-6 for Mirror-Image VHH Discovery -- Chapter 6.Conclusions.
Contained By:	Springer Nature eBook
標題:	Monoclonal antibodies - Synthesis. -
電子資源:	https://doi.org/10.1007/978-981-96-1301-4
ISBN:	9789819613014

Development of mirror-image VHHs with less immunogenicity
Aoki, Keisuke.

Development of mirror-image VHHs with less immunogenicity[electronic resource] /by Keisuke Aoki. - Singapore :Springer Nature Singapore :2025. - xi, 116 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5061. - Springer theses..

"Doctoral thesis accepted by Kyoto University, Kyoto, Japan."

Chapter 1.Introduction -- Chapter 2.Chemical Synthesis of Mirror-Image VHHs and Evaluation of Their Immunogenicity -- Chapter 3.Identification of a Mirror-Image VHH against Vascular Endothelial Growth Factor -- Chapter 4.Synthetic Study of Full-Length Hepatitis B Virus Core Protein and Its Capsid Assembly -- Chapter 5.Chemical Synthesis of Interleukin-6 for Mirror-Image VHH Discovery -- Chapter 6.Conclusions.

This book outlines the chemical synthesis of therapeutic targets and a screening process for unexplored mirror-image single-domain antibodies (D-VHH). This book first describes the chemical synthesis of model VHH and the characteristics of both enantiomeric VHHs, including binding activity, biodistribution and immunogenicity. Immunogenicity testing in mice demonstrated that administration of conventional L-VHH induced the generation of anti-drug antibodies while D-VHH-binding antibodies were not observed in D-VHH-immunized mice. Second, it is explained that the T7-phage-based mirror-image screening system was developed to identify D-VHH antibody fragments capable of binding to vascular endothelial growth factors. Additionally, this book details the chemical synthesis of full-length hepatitis B virus core protein and interleukin-6 for the application of exploring D-VHHs and other mirror-image molecules. Demonstrating that it is possible to develop a D-VHH that preferentially binds the native target protein and exhibits reduced immunogenicity, this book is useful for anyone interested in developing alternative biotherapeutics with reduced immunogenicity by combining chemical and biological approaches.

ISBN: 9789819613014

Standard No.: 10.1007/978-981-96-1301-4doiSubjects--Topical Terms:

3780926
Monoclonal antibodies
--Synthesis.

LC Class. No.: QR186.85

Dewey Class. No.: 616.0798

Development of mirror-image VHHs with less immunogenicity
LDR:02748nmm a2200349 a 4500 001 2408428
003 DE-He213
005 20250114115227.0
006 m d
007 cr nn 008maaau
008 260204s2025 si s 0 eng d
020 $a 9789819613014 $q (electronic bk.)
020 $a 9789819613007 $q (paper)
024 7 $a 10.1007/978-981-96-1301-4 $2 doi
035 $a 978-981-96-1301-4
040 $a GP $c GP
041 0 $a eng
050 4 $a QR186.85
072 7 $a PN $2 bicssc
072 7 $a SCI013000 $2 bisacsh
072 7 $a PN $2 thema
082 0 4 $a 616.0798 $2 23
090 $a QR186.85 $b .A638 2025
100 1 $a Aoki, Keisuke. $3 3780925
245 1 0 $a Development of mirror-image VHHs with less immunogenicity $h [electronic resource] / $c by Keisuke Aoki.
260 $a Singapore : $b Springer Nature Singapore : $b Imprint: Springer, $c 2025.
300 $a xi, 116 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5061
500 $a "Doctoral thesis accepted by Kyoto University, Kyoto, Japan."
505 0 $a Chapter 1.Introduction -- Chapter 2.Chemical Synthesis of Mirror-Image VHHs and Evaluation of Their Immunogenicity -- Chapter 3.Identification of a Mirror-Image VHH against Vascular Endothelial Growth Factor -- Chapter 4.Synthetic Study of Full-Length Hepatitis B Virus Core Protein and Its Capsid Assembly -- Chapter 5.Chemical Synthesis of Interleukin-6 for Mirror-Image VHH Discovery -- Chapter 6.Conclusions.
520 $a This book outlines the chemical synthesis of therapeutic targets and a screening process for unexplored mirror-image single-domain antibodies (D-VHH). This book first describes the chemical synthesis of model VHH and the characteristics of both enantiomeric VHHs, including binding activity, biodistribution and immunogenicity. Immunogenicity testing in mice demonstrated that administration of conventional L-VHH induced the generation of anti-drug antibodies while D-VHH-binding antibodies were not observed in D-VHH-immunized mice. Second, it is explained that the T7-phage-based mirror-image screening system was developed to identify D-VHH antibody fragments capable of binding to vascular endothelial growth factors. Additionally, this book details the chemical synthesis of full-length hepatitis B virus core protein and interleukin-6 for the application of exploring D-VHHs and other mirror-image molecules. Demonstrating that it is possible to develop a D-VHH that preferentially binds the native target protein and exhibits reduced immunogenicity, this book is useful for anyone interested in developing alternative biotherapeutics with reduced immunogenicity by combining chemical and biological approaches.
650 0 $a Monoclonal antibodies $x Synthesis. $3 3780926
650 1 4 $a Chemical Synthesis. $3 3591854
650 2 4 $a Pharmacy. $3 636101
650 2 4 $a Proteins. $3 558769
650 2 4 $a Immunogenetics. $3 907032
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a Springer theses. $3 1314442
856 4 0 $u https://doi.org/10.1007/978-981-96-1301-4
950 $a Chemistry and Materials Science (SpringerNature-11644)