東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Joint Microfluidic Assessment of Loc...

Kang, Junhyuk.

Linked to FindBook

Google Book

Amazon

博客來

Joint Microfluidic Assessment of Local Shear and Shear Historical Effects on Thrombosis: Applications to Heart-Assist Devices and Hyperinflammatory States.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Joint Microfluidic Assessment of Local Shear and Shear Historical Effects on Thrombosis: Applications to Heart-Assist Devices and Hyperinflammatory States./
Author:	Kang, Junhyuk.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	116 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Mechanical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31146693
ISBN:	9798382840321

Joint Microfluidic Assessment of Local Shear and Shear Historical Effects on Thrombosis: Applications to Heart-Assist Devices and Hyperinflammatory States.
Kang, Junhyuk.

Joint Microfluidic Assessment of Local Shear and Shear Historical Effects on Thrombosis: Applications to Heart-Assist Devices and Hyperinflammatory States. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 116 p.

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Cornell University, 2024.

Heart failure repeatedly ranks as one of the leading causes of death worldwide, and the most practical therapeutic strategy is plagued with thrombotic complications. Treatment options for these patients are heart transplantation-which is met with low supply-and heart-assist device implantation. One major characteristic yet undesired feature of heart-assist devices is elevated shear rates throughout the flow circuit. Blood components rely on deviations from physiological shear to sense bleedings events and trigger thrombosis. As a result, thrombotic complications are common in patients with circulatory support devices, and even more so when experiencing acute or chronic inflammation.The current state of knowledge regarding shear effects on thrombosis has largely been achieved through the ability of microfluidic devices. However, there remains a large gap in knowledge about the impact of historical features on thrombosis. The extremely large range of shear rates generated by heart-assist devices can greatly perturb platelets and thrombogenic agents from their resting state at any given moment of flow. Therefore, a locally restricted assessment of shear on thrombotic outcome is insufficient and incomplete, and a more accurate analysis of shear-driven thrombosis requires a device that considers an entire history of shear.This research sets the foundation for studying thrombosis while jointly controlling shear history and shear rates by discussing the theory and design behind a massively parallel microfluidic device. Furthermore, the initiation and evolution of early forming microthrombi is stressed in this work analysis, as these dynamics become muddled with longer perfusion times. These dynamics become resolved once individual thrombi are tracked with perfusion time and when the entire population of developing thrombi are viewed as an ensemble. These tools are highly applicable to the study of other thrombotic complications, and this thesis delves into the problem of immunothrombosis through elevated IL-6 in serum.

ISBN: 9798382840321Subjects--Topical Terms:

649730
Mechanical engineering.
Subjects--Index Terms:

Blood

Joint Microfluidic Assessment of Local Shear and Shear Historical Effects on Thrombosis: Applications to Heart-Assist Devices and Hyperinflammatory States.
LDR:03269nmm a2200397 4500 001 2403651
005 20241118135903.5
006 m o d
007 cr#unu||||||||
008 251215s2024 ||||||||||||||||| ||eng d
020 $a 9798382840321
035 $a (MiAaPQ)AAI31146693
035 $a AAI31146693
040 $a MiAaPQ $c MiAaPQ
100 1 $a Kang, Junhyuk. $0 (orcid)0000-0002-9349-960X $3 3773922
245 1 0 $a Joint Microfluidic Assessment of Local Shear and Shear Historical Effects on Thrombosis: Applications to Heart-Assist Devices and Hyperinflammatory States.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 116 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
500 $a Advisor: Kirby, Brian.
502 $a Thesis (Ph.D.)--Cornell University, 2024.
520 $a Heart failure repeatedly ranks as one of the leading causes of death worldwide, and the most practical therapeutic strategy is plagued with thrombotic complications. Treatment options for these patients are heart transplantation-which is met with low supply-and heart-assist device implantation. One major characteristic yet undesired feature of heart-assist devices is elevated shear rates throughout the flow circuit. Blood components rely on deviations from physiological shear to sense bleedings events and trigger thrombosis. As a result, thrombotic complications are common in patients with circulatory support devices, and even more so when experiencing acute or chronic inflammation.The current state of knowledge regarding shear effects on thrombosis has largely been achieved through the ability of microfluidic devices. However, there remains a large gap in knowledge about the impact of historical features on thrombosis. The extremely large range of shear rates generated by heart-assist devices can greatly perturb platelets and thrombogenic agents from their resting state at any given moment of flow. Therefore, a locally restricted assessment of shear on thrombotic outcome is insufficient and incomplete, and a more accurate analysis of shear-driven thrombosis requires a device that considers an entire history of shear.This research sets the foundation for studying thrombosis while jointly controlling shear history and shear rates by discussing the theory and design behind a massively parallel microfluidic device. Furthermore, the initiation and evolution of early forming microthrombi is stressed in this work analysis, as these dynamics become muddled with longer perfusion times. These dynamics become resolved once individual thrombi are tracked with perfusion time and when the entire population of developing thrombi are viewed as an ensemble. These tools are highly applicable to the study of other thrombotic complications, and this thesis delves into the problem of immunothrombosis through elevated IL-6 in serum.
590 $a School code: 0058.
650 4 $a Mechanical engineering. $3 649730
650 4 $a Biomedical engineering. $3 535387
650 4 $a Fluid mechanics. $3 528155
653 $a Blood
653 $a Fluid dynamics
653 $a Inflammation
653 $a Shear history
653 $a Thrombosis
653 $a Tracking
690 $a 0548
690 $a 0541
690 $a 0204
710 2 $a Cornell University. $b Mechanical Engineering. $3 2093058
773 0 $t Dissertations Abstracts International $g 85-12B.
790 $a 0058
791 $a Ph.D.
792 $a 2024
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31146693