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Concentrating More Than Oxygen: Asse...

Hong, Andrew.

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Concentrating More Than Oxygen: Assessment of Exposure to Environmental Contaminants Enhanced by Oxygen Concentrators.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Concentrating More Than Oxygen: Assessment of Exposure to Environmental Contaminants Enhanced by Oxygen Concentrators./
Author:	Hong, Andrew.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	58 p.
Notes:	Source: Masters Abstracts International, Volume: 85-11.
Contained By:	Masters Abstracts International85-11.
Subject:	Public health. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31244077
ISBN:	9798382456836

Concentrating More Than Oxygen: Assessment of Exposure to Environmental Contaminants Enhanced by Oxygen Concentrators.
Hong, Andrew.

Concentrating More Than Oxygen: Assessment of Exposure to Environmental Contaminants Enhanced by Oxygen Concentrators. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 58 p.

Source: Masters Abstracts International, Volume: 85-11.

Thesis (M.P.H.)--Yale University, 2024.

Background: Oxygen concentrators concentrate oxygen from ambient air by selectively removing nitrogen. These concentrators are typically for personal use by individuals with chronic respiratory failure from various cardio-pulmonary disorders, including chronic obstructive pulmonary disease (COPD) and heart failure. Such concentrators also could potentially concentrate harmful air pollutants and increase adverse health risks. Understanding the mechanisms of separation in an oxygen concentrator could be used to minimize exposures to harmful pollutants.Objective/Methods: The objective of this thesis was to characterize exposures to environmental contaminants in the air supplied by oxygen concentrators. The performance of oxygen concentrators was investigated, and the levels of contaminants detected in the supply and exhaust air of these medical devices was assessed. An oxygen concentrator was used in a controlled office setting and samples were obtained from the intake, output, exhaust, and ambient air locations of the concentrator. Samples were collected using passive air sampling with a sorbet polymer, polydimethylsiloxane (PDMS), and thermal desorption followed by gas chromatography-mass spectrometry (GC-MS) analysis. Correlation heatmaps were generated and clustered compounds were identified. Chemical and physical characteristic comparisons of these clusters were made. Comparisons from the output, exhaust and flow in locations were analyzed and common themes were determined. Statistical analyses, including t-tests, assessed for differences in relative concentration between sampling locations as well as compound characteristics.Results: The subsequent analysis revealed differing levels of chemical contaminants across the flow path of the oxygen concentrator. Poorer adsorption of lighter compounds was detected which increased exposure to these compounds in the air supply to patients, posing potential risks to them. Selective adsorption behaviors were observed, influenced by factors such as molecular weight. Many hazardous compounds showed higher concentrations for the end user, emphasizing the need to understand pollutant characteristics and their separation in oxygen concentrators.Conclusion: Overall, this study contributes to understanding oxygen concentrators' performance in the context of environmental pollution. Assessment of oxygen concentration enrichment of airborne contaminants in real-world settings is warranted and may provide valuable insights into environmental exposures and associated health risks to vulnerable patient population.

ISBN: 9798382456836Subjects--Topical Terms:

534748
Public health.
Subjects--Index Terms:

Oxygen concentrators

Concentrating More Than Oxygen: Assessment of Exposure to Environmental Contaminants Enhanced by Oxygen Concentrators.
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100 1 $a Hong, Andrew. $3 3773580
245 1 0 $a Concentrating More Than Oxygen: Assessment of Exposure to Environmental Contaminants Enhanced by Oxygen Concentrators.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 58 p.
500 $a Source: Masters Abstracts International, Volume: 85-11.
500 $a Advisor: Pollitt, Krystal;Redlich, Carrie.
502 $a Thesis (M.P.H.)--Yale University, 2024.
520 $a Background: Oxygen concentrators concentrate oxygen from ambient air by selectively removing nitrogen. These concentrators are typically for personal use by individuals with chronic respiratory failure from various cardio-pulmonary disorders, including chronic obstructive pulmonary disease (COPD) and heart failure. Such concentrators also could potentially concentrate harmful air pollutants and increase adverse health risks. Understanding the mechanisms of separation in an oxygen concentrator could be used to minimize exposures to harmful pollutants.Objective/Methods: The objective of this thesis was to characterize exposures to environmental contaminants in the air supplied by oxygen concentrators. The performance of oxygen concentrators was investigated, and the levels of contaminants detected in the supply and exhaust air of these medical devices was assessed. An oxygen concentrator was used in a controlled office setting and samples were obtained from the intake, output, exhaust, and ambient air locations of the concentrator. Samples were collected using passive air sampling with a sorbet polymer, polydimethylsiloxane (PDMS), and thermal desorption followed by gas chromatography-mass spectrometry (GC-MS) analysis. Correlation heatmaps were generated and clustered compounds were identified. Chemical and physical characteristic comparisons of these clusters were made. Comparisons from the output, exhaust and flow in locations were analyzed and common themes were determined. Statistical analyses, including t-tests, assessed for differences in relative concentration between sampling locations as well as compound characteristics.Results: The subsequent analysis revealed differing levels of chemical contaminants across the flow path of the oxygen concentrator. Poorer adsorption of lighter compounds was detected which increased exposure to these compounds in the air supply to patients, posing potential risks to them. Selective adsorption behaviors were observed, influenced by factors such as molecular weight. Many hazardous compounds showed higher concentrations for the end user, emphasizing the need to understand pollutant characteristics and their separation in oxygen concentrators.Conclusion: Overall, this study contributes to understanding oxygen concentrators' performance in the context of environmental pollution. Assessment of oxygen concentration enrichment of airborne contaminants in real-world settings is warranted and may provide valuable insights into environmental exposures and associated health risks to vulnerable patient population.
590 $a School code: 0265.
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650 4 $a Environmental health. $3 543032
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653 $a Chronic obstructive pulmonary disease
653 $a Polydimethylsiloxane
653 $a Patient population
690 $a 0470
690 $a 0573
710 2 $a Yale University. $b Occupational and Enviromental Medicine. $3 3773581
773 0 $t Masters Abstracts International $g 85-11.
790 $a 0265
791 $a M.P.H.
792 $a 2024
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31244077