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A New Spin on the Origin of Biologic...

Ozturk, Sukru Furkan.

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A New Spin on the Origin of Biological Homochirality.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A New Spin on the Origin of Biological Homochirality./
Author:	Ozturk, Sukru Furkan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	233 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Physics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31295392
ISBN:	9798382775647

A New Spin on the Origin of Biological Homochirality.
Ozturk, Sukru Furkan.

A New Spin on the Origin of Biological Homochirality. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 233 p.

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Harvard University, 2024.

Essential molecules of life-amino acids, nucleic acids, and sugars-are chiral; they exist in mirror-symmetrical pairs. However, biological systems exclusively use only one form of these pairs: right-handed sugars and nucleic acids, along with left-handed amino acids. This phenomenon characterizes life as homochiral. However, the origins of this asymmetry remain elusive, and it is this long-standing mystery that we address in this thesis.The chiral-induced spin selectivity (CISS) effect has established a strong coupling between electron spin and molecular chirality and this coupling paves the way for breaking the chiral molecular symmetry by spin-selective processes. Achiral magnetic surfaces, when spin-polarized, can function as chiral agents due to the CISS effect, serving as templates for the asymmetric crystallization of chiral molecules.In this thesis, we studied the spin-selective crystallization of racemic ribo-aminooxazoline (RAO), a central precursor of RNA, on magnetite surfaces-achieving homochirality in two crystallization steps. Moreover, we have shown the chirality-induced avalanche magnetization of magnetite by RAO molecules, which verifies the reciprocal nature of the effect and allows for a cooperative feedback between chiral molecules and magnetic surfaces. Finally, based on empirical evidence, we propose a pathway through which the achieved homochirality in a single chiral compound, RAO, can efficiently propagate throughout the entire prebiotic network, starting from D-nucleic acids, to L-peptides, and then to homochiral metabolites.Our results demonstrate a prebiotically plausible way of achieving systems-level homochirality from completely racemic starting materials through a process initiated by the physical environment.

ISBN: 9798382775647Subjects--Topical Terms:

516296
Physics.
Subjects--Index Terms:

Chiral-induced spin selectivity

A New Spin on the Origin of Biological Homochirality.
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300 $a 233 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
500 $a Advisor: Sasselov, Dimitar.
502 $a Thesis (Ph.D.)--Harvard University, 2024.
520 $a Essential molecules of life-amino acids, nucleic acids, and sugars-are chiral; they exist in mirror-symmetrical pairs. However, biological systems exclusively use only one form of these pairs: right-handed sugars and nucleic acids, along with left-handed amino acids. This phenomenon characterizes life as homochiral. However, the origins of this asymmetry remain elusive, and it is this long-standing mystery that we address in this thesis.The chiral-induced spin selectivity (CISS) effect has established a strong coupling between electron spin and molecular chirality and this coupling paves the way for breaking the chiral molecular symmetry by spin-selective processes. Achiral magnetic surfaces, when spin-polarized, can function as chiral agents due to the CISS effect, serving as templates for the asymmetric crystallization of chiral molecules.In this thesis, we studied the spin-selective crystallization of racemic ribo-aminooxazoline (RAO), a central precursor of RNA, on magnetite surfaces-achieving homochirality in two crystallization steps. Moreover, we have shown the chirality-induced avalanche magnetization of magnetite by RAO molecules, which verifies the reciprocal nature of the effect and allows for a cooperative feedback between chiral molecules and magnetic surfaces. Finally, based on empirical evidence, we propose a pathway through which the achieved homochirality in a single chiral compound, RAO, can efficiently propagate throughout the entire prebiotic network, starting from D-nucleic acids, to L-peptides, and then to homochiral metabolites.Our results demonstrate a prebiotically plausible way of achieving systems-level homochirality from completely racemic starting materials through a process initiated by the physical environment.
590 $a School code: 0084.
650 4 $a Physics. $3 516296
650 4 $a Molecular physics. $3 3174737
650 4 $a Organic chemistry. $3 523952
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653 $a Homochirality
653 $a Magnetite
653 $a Ribose-aminooxazoline
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710 2 $a Harvard University. $b Physics. $3 2094825
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792 $a 2024
793 $a English
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