東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Integrative Genomic Analysis of the ...

Baez, Aldo Carmona.

FindBook

Google Book

Amazon

博客來

Integrative Genomic Analysis of the Evolution of Trophic Level in Lake Malawi Cichlid Fishes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Integrative Genomic Analysis of the Evolution of Trophic Level in Lake Malawi Cichlid Fishes./
作者:	Baez, Aldo Carmona.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	165 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-01, Section: A.
Contained By:	Dissertations Abstracts International85-01A.
標題:	Physiology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30516352
ISBN:	9798379870799

Integrative Genomic Analysis of the Evolution of Trophic Level in Lake Malawi Cichlid Fishes.
Baez, Aldo Carmona.

Integrative Genomic Analysis of the Evolution of Trophic Level in Lake Malawi Cichlid Fishes. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 165 p.

Source: Dissertations Abstracts International, Volume: 85-01, Section: A.

Thesis (Ph.D.)--North Carolina State University, 2023.

The genetic basis of trophic level adaptations is a fundamental biological question that, until a few years ago, had remained widely unexplored. In order to tackle this question, a few previous studies have taken advantage of species radiations to explore this question, given the phylogenetic proximity of the species within them and the niche specialization diversity they tend to exhibit. In this work, we expand our knowledge of the genetic basis of trophic level adaptation by studying the Lake Malawi cichlid radiation. Cichlids, as other radiations, display a vast diversity of dietary specializations, close phylogenetic diversity that allows for hybridization between species from different trophic levels, and laboratory tractability. By harnessing these attributes, in this work we study the genetic basis of key dietary traits and look for novel candidate genes involved in the adaptation to novel diets.In CHAPTER 2, I perform a comparative genomics analysis in order to identify regions in the genome displaying signatures of divergence across trophic levels. Through this exploration I identify novel candidate genes, such as laminins and sulfotransferases. I am also able to identify two previously reported candidate genes in cichlids, patched1 (a developmental gene involved in jaw morphology) and amylase (a classic example of a gene that has been target of convergent evolution and that is involved in diet adaptation).In CHAPTER 3, I perform a QTL mapping analysis to elucidate the genetic architecture of a key dietary trait: gut length. Despite its importance, this analysis represents only the second attempt to map this trait in a non-agricultural species. The results show that gut length has a sexspecific genetic architecture, suggesting that gut length may be under sexual conflict in some species of the Malawi radiation.In CHAPTER 4, I perform a comparative transcriptomic analysis in order to identify differences in gene expression in the gut tissue of cichlids before the onset of external feeding. By using this experimental design, we are able to reduce the influence of environmental effects and identify genetically hard-wired differences in intestinal gene expression. This analysis uncovered new candidate genes involved in trophic adaptation, in particular several genes associated with immune system responses, membrane transport, and fatty acid metabolism.

ISBN: 9798379870799Subjects--Topical Terms:

518431
Physiology.

Integrative Genomic Analysis of the Evolution of Trophic Level in Lake Malawi Cichlid Fishes.
LDR:03696nmm a2200445 4500 001 2401280
005 20241022112124.5
006 m o d
007 cr#unu||||||||
008 251215s2023 ||||||||||||||||| ||eng d
020 $a 9798379870799
035 $a (MiAaPQ)AAI30516352
035 $a (MiAaPQ)NCState_Univ18402040805
035 $a AAI30516352
035 $a 2401280
040 $a MiAaPQ $c MiAaPQ
100 1 $a Baez, Aldo Carmona. $3 3771364
245 1 0 $a Integrative Genomic Analysis of the Evolution of Trophic Level in Lake Malawi Cichlid Fishes.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 165 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-01, Section: A.
500 $a Advisor: Cowley, Michael;Nielsen, Dahlia;Reif, David;Roberts, Reade B.
502 $a Thesis (Ph.D.)--North Carolina State University, 2023.
520 $a The genetic basis of trophic level adaptations is a fundamental biological question that, until a few years ago, had remained widely unexplored. In order to tackle this question, a few previous studies have taken advantage of species radiations to explore this question, given the phylogenetic proximity of the species within them and the niche specialization diversity they tend to exhibit. In this work, we expand our knowledge of the genetic basis of trophic level adaptation by studying the Lake Malawi cichlid radiation. Cichlids, as other radiations, display a vast diversity of dietary specializations, close phylogenetic diversity that allows for hybridization between species from different trophic levels, and laboratory tractability. By harnessing these attributes, in this work we study the genetic basis of key dietary traits and look for novel candidate genes involved in the adaptation to novel diets.In CHAPTER 2, I perform a comparative genomics analysis in order to identify regions in the genome displaying signatures of divergence across trophic levels. Through this exploration I identify novel candidate genes, such as laminins and sulfotransferases. I am also able to identify two previously reported candidate genes in cichlids, patched1 (a developmental gene involved in jaw morphology) and amylase (a classic example of a gene that has been target of convergent evolution and that is involved in diet adaptation).In CHAPTER 3, I perform a QTL mapping analysis to elucidate the genetic architecture of a key dietary trait: gut length. Despite its importance, this analysis represents only the second attempt to map this trait in a non-agricultural species. The results show that gut length has a sexspecific genetic architecture, suggesting that gut length may be under sexual conflict in some species of the Malawi radiation.In CHAPTER 4, I perform a comparative transcriptomic analysis in order to identify differences in gene expression in the gut tissue of cichlids before the onset of external feeding. By using this experimental design, we are able to reduce the influence of environmental effects and identify genetically hard-wired differences in intestinal gene expression. This analysis uncovered new candidate genes involved in trophic adaptation, in particular several genes associated with immune system responses, membrane transport, and fatty acid metabolism.
590 $a School code: 0155.
650 4 $a Physiology. $3 518431
650 4 $a Behavior. $3 532476
650 4 $a Phylogenetics. $3 3561778
650 4 $a Evolution. $3 532919
650 4 $a Ontology. $3 530874
650 4 $a Genetics. $3 530508
650 4 $a Zoology. $3 518878
650 4 $a Adaptation. $3 3562958
650 4 $a Diet. $3 626002
650 4 $a Genomes. $3 592593
650 4 $a Metabolism. $3 541349
650 4 $a Genomics. $3 600531
650 4 $a Gene loci. $3 3561757
650 4 $a Radiation. $3 673904
650 4 $a Ecology. $3 516476
650 4 $a Gene expression. $3 643979
650 4 $a Herbivores. $3 1899108
650 4 $a Microbiota. $3 3310213
650 4 $a Chromosomes. $3 638948
650 4 $a Evolutionary biology. $3 3251503
650 4 $a Food chains. $3 3680771
650 4 $a Morphology. $3 591167
650 4 $a Bioinformatics. $3 553671
650 4 $a Biology. $3 522710
650 4 $a Evolution & development. $3 3172418
650 4 $a Microbiology. $3 536250
650 4 $a Sub Saharan Africa studies. $3 3172272
650 4 $a Systematic biology. $3 3173492
690 $a 0472
690 $a 0369
690 $a 0329
690 $a 0287
690 $a 0719
690 $a 0715
690 $a 0306
690 $a 0412
690 $a 0410
690 $a 0639
690 $a 0423
710 2 $a North Carolina State University. $3 1018772
773 0 $t Dissertations Abstracts International $g 85-01A.
790 $a 0155
791 $a Ph.D.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30516352