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The Design and Characterization of a...
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Wolf, Ann.
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The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications./
作者:
Wolf, Ann.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:
62 p.
附註:
Source: Masters Abstracts International, Volume: 84-01.
Contained By:
Masters Abstracts International84-01.
標題:
Electrical engineering. -
電子資源:
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29281411
ISBN:
9798802742402
The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
Wolf, Ann.
The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
- Ann Arbor : ProQuest Dissertations & Theses, 2022 - 62 p.
Source: Masters Abstracts International, Volume: 84-01.
Thesis (M.S.)--University of Cincinnati, 2022.
Severe peripheral nerve injuries are currently limited in their available treatment approaches. Standard clinical therapies include the use of nerve grafts or nerve conduits to guide axons across the injury gap, however many of these approaches show variable outcomes in functional recovery, possibly due to a lack of cues directing the nerve regeneration. Polyvinylidene flouride triflouroethylene (PVDF-TrFE) is a piezoelectric polymer that generates electric charge in response to mechanical deformation, and can provide a suitable regenerative microenvironment by imparting electrical stimulation to direct peripheral nervous system cells and function. In this thesis, PVDF-TrFE nanofibrous scaffolds are fabricated through electrospinning and are extensively characterized for their material and electrical properties. Further, the PVDF-TrFE scaffolds are functionalized with decellularized extracellular matrix (dECM), presenting a promising outlook for a piezoelectric biomaterial for tissue engineering.
ISBN: 9798802742402Subjects--Topical Terms:
649834
Electrical engineering.
Subjects--Index Terms:
Piezoelectric polymer
The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
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Severe peripheral nerve injuries are currently limited in their available treatment approaches. Standard clinical therapies include the use of nerve grafts or nerve conduits to guide axons across the injury gap, however many of these approaches show variable outcomes in functional recovery, possibly due to a lack of cues directing the nerve regeneration. Polyvinylidene flouride triflouroethylene (PVDF-TrFE) is a piezoelectric polymer that generates electric charge in response to mechanical deformation, and can provide a suitable regenerative microenvironment by imparting electrical stimulation to direct peripheral nervous system cells and function. In this thesis, PVDF-TrFE nanofibrous scaffolds are fabricated through electrospinning and are extensively characterized for their material and electrical properties. Further, the PVDF-TrFE scaffolds are functionalized with decellularized extracellular matrix (dECM), presenting a promising outlook for a piezoelectric biomaterial for tissue engineering.
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