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The Design and Characterization of a...

Wolf, Ann.

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The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications./
Author:	Wolf, Ann.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
Description:	62 p.
Notes:	Source: Masters Abstracts International, Volume: 84-01.
Contained By:	Masters Abstracts International84-01.
Subject:	Electrical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29281411
ISBN:	9798802742402

The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
Wolf, Ann.

The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 62 p.

Source: Masters Abstracts International, Volume: 84-01.

Thesis (M.S.)--University of Cincinnati, 2022.

Severe peripheral nerve injuries are currently limited in their available treatment approaches. Standard clinical therapies include the use of nerve grafts or nerve conduits to guide axons across the injury gap, however many of these approaches show variable outcomes in functional recovery, possibly due to a lack of cues directing the nerve regeneration. Polyvinylidene flouride triflouroethylene (PVDF-TrFE) is a piezoelectric polymer that generates electric charge in response to mechanical deformation, and can provide a suitable regenerative microenvironment by imparting electrical stimulation to direct peripheral nervous system cells and function. In this thesis, PVDF-TrFE nanofibrous scaffolds are fabricated through electrospinning and are extensively characterized for their material and electrical properties. Further, the PVDF-TrFE scaffolds are functionalized with decellularized extracellular matrix (dECM), presenting a promising outlook for a piezoelectric biomaterial for tissue engineering.

ISBN: 9798802742402Subjects--Topical Terms:

649834
Electrical engineering.
Subjects--Index Terms:

Piezoelectric polymer

The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
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245 1 0 $a The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
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300 $a 62 p.
500 $a Source: Masters Abstracts International, Volume: 84-01.
500 $a Advisor: Esfandiari, Leyla.
502 $a Thesis (M.S.)--University of Cincinnati, 2022.
520 $a Severe peripheral nerve injuries are currently limited in their available treatment approaches. Standard clinical therapies include the use of nerve grafts or nerve conduits to guide axons across the injury gap, however many of these approaches show variable outcomes in functional recovery, possibly due to a lack of cues directing the nerve regeneration. Polyvinylidene flouride triflouroethylene (PVDF-TrFE) is a piezoelectric polymer that generates electric charge in response to mechanical deformation, and can provide a suitable regenerative microenvironment by imparting electrical stimulation to direct peripheral nervous system cells and function. In this thesis, PVDF-TrFE nanofibrous scaffolds are fabricated through electrospinning and are extensively characterized for their material and electrical properties. Further, the PVDF-TrFE scaffolds are functionalized with decellularized extracellular matrix (dECM), presenting a promising outlook for a piezoelectric biomaterial for tissue engineering.
590 $a School code: 0045.
650 4 $a Electrical engineering. $3 649834
650 4 $a Neurosciences. $3 588700
650 4 $a Histology. $3 641250
650 4 $a Polymer chemistry. $3 3173488
650 4 $a Chemical engineering. $3 560457
653 $a Piezoelectric polymer
653 $a Nerve repair
653 $a PVDF
653 $a Nerve injury
653 $a Polyvinylidene Flouride Triflouroethylene
653 $a Tissue engineering
690 $a 0544
690 $a 0542
690 $a 0317
690 $a 0414
690 $a 0495
710 2 $a University of Cincinnati. $b Engineering and Applied Science: Electrical Engineering. $3 3184269
773 0 $t Masters Abstracts International $g 84-01.
790 $a 0045
791 $a M.S.
792 $a 2022
793 $a English
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