東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

A Novel Input to the Circadian Syste...

Warfield, Andrew Erickson.

FindBook

Google Book

Amazon

博客來

A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease./
作者:	Warfield, Andrew Erickson.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	242 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
Contained By:	Dissertations Abstracts International85-02B.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30575681
ISBN:	9798380143110

A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease.
Warfield, Andrew Erickson.

A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 242 p.

Source: Dissertations Abstracts International, Volume: 85-02, Section: B.

Thesis (Ph.D.)--University of Wyoming, 2023.

Circadian Rhythms are Ubiquitous and regulate the most essential physiological and behavioral processes of life. These rhythms are endogenously generated and tightly entrained to daily lighting ques based on the twenty-four hour rotation of Earth. Generation of circadian rhythmicity comes from rhythmic electrical activity in vasoactive intestinal polypeptide (VIP) cells of the superchiasmatic nucleus (SCN) and flows through its obligate relay, the subparaventricular zone (SPZ), which lies just dorsally to the SCN. These rhythms are entrained through neural innervation of melanopsin retinal ganglion cells travelling through the retinohypothalamic tract (RHT). However, the RHT is not the only input to the SCN and SPZ. The work in this dissertation characterizes a novel input to these circadian centers coming from dynorphin cells of the lateral parabrachial nucleus (LPBdyn) and describes the role that this neural circuit has in: 1.) Alzheimer's disease (AD) and sundowning syndrome, through the accumulation of hyperphosphorylated tau (pTau) in these cells and 2.) Pain through the over-activation of these cells following neuropathic injury. Chronic pain and AD are among the most costly and prevalent conditions across the globe in terms of both economic burden and deterioration of quality of life. Each of these conditions disrupt circadian rhythmicity worsening many of the most costly symptoms of these diseases. Understanding the mechanism of these disruptions will provide crucial information towards future research and clinical practice aimed at the prevention and resolution of these conditions.

ISBN: 9798380143110Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Alzheimer's disease

A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease.
LDR:02812nmm a2200421 4500 001 2401105
005 20241015112527.5
006 m o d
007 cr#unu||||||||
008 251215s2023 ||||||||||||||||| ||eng d
020 $a 9798380143110
035 $a (MiAaPQ)AAI30575681
035 $a AAI30575681
035 $a 2401105
040 $a MiAaPQ $c MiAaPQ
100 1 $a Warfield, Andrew Erickson. $3 3771169
245 1 2 $a A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 242 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
500 $a Advisor: Todd, William D.
502 $a Thesis (Ph.D.)--University of Wyoming, 2023.
520 $a Circadian Rhythms are Ubiquitous and regulate the most essential physiological and behavioral processes of life. These rhythms are endogenously generated and tightly entrained to daily lighting ques based on the twenty-four hour rotation of Earth. Generation of circadian rhythmicity comes from rhythmic electrical activity in vasoactive intestinal polypeptide (VIP) cells of the superchiasmatic nucleus (SCN) and flows through its obligate relay, the subparaventricular zone (SPZ), which lies just dorsally to the SCN. These rhythms are entrained through neural innervation of melanopsin retinal ganglion cells travelling through the retinohypothalamic tract (RHT). However, the RHT is not the only input to the SCN and SPZ. The work in this dissertation characterizes a novel input to these circadian centers coming from dynorphin cells of the lateral parabrachial nucleus (LPBdyn) and describes the role that this neural circuit has in: 1.) Alzheimer's disease (AD) and sundowning syndrome, through the accumulation of hyperphosphorylated tau (pTau) in these cells and 2.) Pain through the over-activation of these cells following neuropathic injury. Chronic pain and AD are among the most costly and prevalent conditions across the globe in terms of both economic burden and deterioration of quality of life. Each of these conditions disrupt circadian rhythmicity worsening many of the most costly symptoms of these diseases. Understanding the mechanism of these disruptions will provide crucial information towards future research and clinical practice aimed at the prevention and resolution of these conditions.
590 $a School code: 0264.
650 4 $a Neurosciences. $3 588700
650 4 $a Physiology. $3 518431
650 4 $a Cellular biology. $3 3172791
650 4 $a Physiological psychology. $3 2144820
653 $a Alzheimer's disease
653 $a Circadian Rhythms
653 $a Pain
653 $a LPB
653 $a Sundowning
653 $a Tau
690 $a 0317
690 $a 0379
690 $a 0989
690 $a 0719
710 2 $a University of Wyoming. $b Zoology & Physiology. $3 2100141
773 0 $t Dissertations Abstracts International $g 85-02B.
790 $a 0264
791 $a Ph.D.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30575681