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A Novel Input to the Circadian Syste...

Warfield, Andrew Erickson.

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A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease./
Author:	Warfield, Andrew Erickson.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	242 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
Contained By:	Dissertations Abstracts International85-02B.
Subject:	Neurosciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30575681
ISBN:	9798380143110

A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease.
Warfield, Andrew Erickson.

A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 242 p.

Source: Dissertations Abstracts International, Volume: 85-02, Section: B.

Thesis (Ph.D.)--University of Wyoming, 2023.

Circadian Rhythms are Ubiquitous and regulate the most essential physiological and behavioral processes of life. These rhythms are endogenously generated and tightly entrained to daily lighting ques based on the twenty-four hour rotation of Earth. Generation of circadian rhythmicity comes from rhythmic electrical activity in vasoactive intestinal polypeptide (VIP) cells of the superchiasmatic nucleus (SCN) and flows through its obligate relay, the subparaventricular zone (SPZ), which lies just dorsally to the SCN. These rhythms are entrained through neural innervation of melanopsin retinal ganglion cells travelling through the retinohypothalamic tract (RHT). However, the RHT is not the only input to the SCN and SPZ. The work in this dissertation characterizes a novel input to these circadian centers coming from dynorphin cells of the lateral parabrachial nucleus (LPBdyn) and describes the role that this neural circuit has in: 1.) Alzheimer's disease (AD) and sundowning syndrome, through the accumulation of hyperphosphorylated tau (pTau) in these cells and 2.) Pain through the over-activation of these cells following neuropathic injury. Chronic pain and AD are among the most costly and prevalent conditions across the globe in terms of both economic burden and deterioration of quality of life. Each of these conditions disrupt circadian rhythmicity worsening many of the most costly symptoms of these diseases. Understanding the mechanism of these disruptions will provide crucial information towards future research and clinical practice aimed at the prevention and resolution of these conditions.

ISBN: 9798380143110Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Alzheimer's disease

A Novel Input to the Circadian System and Its Role in Pain and Alzheimer's Disease.
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