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Engineering and On-Skin Validation o...

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Engineering and On-Skin Validation of a Novel Osmotic-capillary Wearable Patch for Long-term Sweat Lactate Monitoring.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Engineering and On-Skin Validation of a Novel Osmotic-capillary Wearable Patch for Long-term Sweat Lactate Monitoring./
Author:	Saha, Tamoghna.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
Description:	203 p.
Notes:	Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
Contained By:	Dissertations Abstracts International84-04B.
Subject:	Physiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29419994
ISBN:	9798352652619

Engineering and On-Skin Validation of a Novel Osmotic-capillary Wearable Patch for Long-term Sweat Lactate Monitoring.
Saha, Tamoghna.

Engineering and On-Skin Validation of a Novel Osmotic-capillary Wearable Patch for Long-term Sweat Lactate Monitoring. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 203 p.

Source: Dissertations Abstracts International, Volume: 84-04, Section: B.

Thesis (Ph.D.)--North Carolina State University, 2022.

Biomarkers in sweat are a largely untapped source of health information. However, most of the currently available sweat sensing devices require external power, cannot measure these biomarkers under low sweat rates (such as in humans at rest), and do not provide adequate information about the relationship between sweat and blood biomarker levels. Hence, these devices mainly rely on active perspiration for their operation. Biomarker analysis via active sweating is not only inconvenient and tedious (since it requires strenuous exercise) but also raises additional questions concerning its clean capture, external contamination, error in measurements due to uncontrolled evaporation, and dilution due to excessive sweating. Furthermore, these devices get saturated quickly as they operate with large sweat volumes and cannot operate longterm (for hours) Thus, there remains a need for techniques that could allow efficient collection and transport of small volumes of fluid from skin to sensors for long-term and continuous biomarker monitoring.This dissertation presents the design, in-vitro, and in-vivo (on-skin) validation of a novel wearable prototype concept, which combines a few fluid withdrawing techniques that have not been used earlier in sweat-based wearables. Our prototype simultaneously uses osmosis (zero external power), generated by a hydrogel disk interfacing the skin for non-invasive and exertionfree sweat sampling, and a paper microfluidic channel with an evaporation pad at the end for maintaining long-term sweat inflow and sensing.We initially introduce the design of our novel, non-invasive, wearable, zero-powered sweat sampling patch that functions without the necessity of active sweat release prior to testing. We validate the functioning of the patch in in-vitro (benchtop) settings to investigate the role of osmosis, evaporation, hydrogel surface area, paper pore size, and transport effects at the paperhydrogel interface towards long-term biomarker collection.his report is followed by the data on the in-vivo (on-skin) validation of the patch which was used to sample sweat lactate under rest, varying levels of exercise, and post-exercise conditions. We showed that sweat lactate was sampled mostly via osmosis in measurements from subjects at rest, while from actively generated sweat during exercise trials.We also develop a continuous sweat lactate sensing platform through the integration of our previously introduced sweat sampling patch with enzymatic electrochemical sensors. The platform was validated under in-vitro (benchtop) and in-vivo (on-skin) settings. It could also be connected to a flexible circuit board including Bluetooth data transmission modules and tested through realtime monitoring of sweat lactate trend on a wireless device, such as an iPad.Finally, we demonstrate how our novel osmotic-capillary platform can be integrated with microneedle patches to develop a long-term (~ hours) interstitial fluid (ISF) sampling platform. Instead of glucose hydrogels, we use a novel "glycerogel" medium (hydrogel infused with pure glycerin) to serve this purpose. We validated this integrated system under in-vitro settings, where we found that this integrated platform can sample model biomarkers for up to 5 hours.Overall, implementation of such new principles for sweat fluid harvesting and management via wearable patch devices can contribute toward the advancement of next generation wearables, which will provide comprehensive analysis of different sweat biomarker trends in the human body.

ISBN: 9798352652619Subjects--Topical Terms:

518431
Physiology.

Engineering and On-Skin Validation of a Novel Osmotic-capillary Wearable Patch for Long-term Sweat Lactate Monitoring.
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245 1 0 $a Engineering and On-Skin Validation of a Novel Osmotic-capillary Wearable Patch for Long-term Sweat Lactate Monitoring.
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300 $a 203 p.
500 $a Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
500 $a Advisor: Bandodkar, Amay;Daniele, Michael A. ;Wei, Qingshan;Dickey, Michael D. ;Velev, Orlin D. .
502 $a Thesis (Ph.D.)--North Carolina State University, 2022.
520 $a Biomarkers in sweat are a largely untapped source of health information. However, most of the currently available sweat sensing devices require external power, cannot measure these biomarkers under low sweat rates (such as in humans at rest), and do not provide adequate information about the relationship between sweat and blood biomarker levels. Hence, these devices mainly rely on active perspiration for their operation. Biomarker analysis via active sweating is not only inconvenient and tedious (since it requires strenuous exercise) but also raises additional questions concerning its clean capture, external contamination, error in measurements due to uncontrolled evaporation, and dilution due to excessive sweating. Furthermore, these devices get saturated quickly as they operate with large sweat volumes and cannot operate longterm (for hours) Thus, there remains a need for techniques that could allow efficient collection and transport of small volumes of fluid from skin to sensors for long-term and continuous biomarker monitoring.This dissertation presents the design, in-vitro, and in-vivo (on-skin) validation of a novel wearable prototype concept, which combines a few fluid withdrawing techniques that have not been used earlier in sweat-based wearables. Our prototype simultaneously uses osmosis (zero external power), generated by a hydrogel disk interfacing the skin for non-invasive and exertionfree sweat sampling, and a paper microfluidic channel with an evaporation pad at the end for maintaining long-term sweat inflow and sensing.We initially introduce the design of our novel, non-invasive, wearable, zero-powered sweat sampling patch that functions without the necessity of active sweat release prior to testing. We validate the functioning of the patch in in-vitro (benchtop) settings to investigate the role of osmosis, evaporation, hydrogel surface area, paper pore size, and transport effects at the paperhydrogel interface towards long-term biomarker collection.his report is followed by the data on the in-vivo (on-skin) validation of the patch which was used to sample sweat lactate under rest, varying levels of exercise, and post-exercise conditions. We showed that sweat lactate was sampled mostly via osmosis in measurements from subjects at rest, while from actively generated sweat during exercise trials.We also develop a continuous sweat lactate sensing platform through the integration of our previously introduced sweat sampling patch with enzymatic electrochemical sensors. The platform was validated under in-vitro (benchtop) and in-vivo (on-skin) settings. It could also be connected to a flexible circuit board including Bluetooth data transmission modules and tested through realtime monitoring of sweat lactate trend on a wireless device, such as an iPad.Finally, we demonstrate how our novel osmotic-capillary platform can be integrated with microneedle patches to develop a long-term (~ hours) interstitial fluid (ISF) sampling platform. Instead of glucose hydrogels, we use a novel "glycerogel" medium (hydrogel infused with pure glycerin) to serve this purpose. We validated this integrated system under in-vitro settings, where we found that this integrated platform can sample model biomarkers for up to 5 hours.Overall, implementation of such new principles for sweat fluid harvesting and management via wearable patch devices can contribute toward the advancement of next generation wearables, which will provide comprehensive analysis of different sweat biomarker trends in the human body.
590 $a School code: 0155.
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650 4 $a Hormones. $3 548778
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650 4 $a Humidity. $3 3559498
650 4 $a Sampling techniques. $3 3685918
650 4 $a Sweating. $3 3770858
650 4 $a Carbon. $3 604057
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650 4 $a Sensors. $3 3549539
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650 4 $a Alcohol. $3 872287
650 4 $a Skin. $3 843661
650 4 $a Metabolism. $3 541349
650 4 $a Exocrine glands. $3 3594272
650 4 $a Metabolites. $3 683644
650 4 $a Human subjects. $3 3562959
650 4 $a Hydrogels. $3 1305894
650 4 $a Biology. $3 522710
650 4 $a Electrical engineering. $3 649834
650 4 $a Endocrinology. $3 610914
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710 2 $a North Carolina State University. $3 1018772
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