東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Investigating the Role of the Gut Mi...

Terauchi, Hinako,

FindBook

Google Book

Amazon

博客來

Investigating the Role of the Gut Microbiome and the Gut Metabolome in the Development of Childhood Eczema and Asthma /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigating the Role of the Gut Microbiome and the Gut Metabolome in the Development of Childhood Eczema and Asthma // Hinako Terauchi.
作者:	Terauchi, Hinako,
面頁冊數:	1 electronic resource (234 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
標題:	Microbiology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30813549
ISBN:	9798381381818

Investigating the Role of the Gut Microbiome and the Gut Metabolome in the Development of Childhood Eczema and Asthma /
Terauchi, Hinako,

Investigating the Role of the Gut Microbiome and the Gut Metabolome in the Development of Childhood Eczema and Asthma /Hinako Terauchi. - 1 electronic resource (234 pages)

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

In United States alone, more than 1 in 4 children are diagnosed with some form of allergy, yet the exact etiology of allergy development in childhood is unknown. Many factors have been associated with this rise in such disorders including genetics, epigenetics, environmental toxins and particulates, as well as the microbiota. The host microbiome has been associated with a multitude of human and animal diseases, disorders, and conditions. Its involvement in the atopic and autoimmune disorders is an every-growing field of new knowledge. In this work, I explore the effect of the gut microbiome on allergy, specifically childhood eczema and asthma, using samples and data collected from the Isle of Wight allergy study cohort as well as a fecal-transplanted humanized microbiota mouse models. In addition, measured specific gut metabolites that were significant in distinguishing between the pathology phenotypes in both study sets will be discussed. In chapter 1, I explored the gut bacterial microbiota of infants in the Isle of Wight allergy study cohort and their association with their development in eczema. We also explored bacterial taxa previously shown in published work to be associated with allergy as agonists or antagonists. Subsequent statistical analyses including random forest and logistic regressions supported these findings and results from logistic regressions provide statistical significance for the association of eczema status at age 3 months with the relative abundance of genus Veillonella at that age. In chapter 2, a study conducted using a mouse model of asthma created by fecal transplantation of the infants featured in chapter 1, connection between gut microbiota in infancy and lung baseline responses were studied and supported. In chapter 4, the role of the gut metabolome in the development of allergic phenotype was explored using the samples from both chapters 1 and 2, where it was shown that infants with allergic phenotype have a distinct gut metabolomic profile compared to infants without allergic phenotype; and mice with reduced lung functionality expressed a distinct gut metabolic profiles compared to mice without reduced lung functionality. Overall, these studies confirmed previously associated relationship between specific bacterial taxa and allergy using a unique infant cohort as well as an original mouse model, while also providing new points of interest to further deepen the understanding of the relationship and the interaction between the gut contents and the host's development of allergy.

English

ISBN: 9798381381818Subjects--Topical Terms:

536250
Microbiology.
Subjects--Index Terms:

Childhood eczema

Investigating the Role of the Gut Microbiome and the Gut Metabolome in the Development of Childhood Eczema and Asthma /
LDR:04116nmm a22004573i 4500 001 2400511
005 20250522084142.5
006 m o d
007 cr|nu||||||||
008 251215s2024 miu||||||m |||||||eng d
020 $a 9798381381818
035 $a (MiAaPQD)AAI30813549
035 $a AAI30813549
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Terauchi, Hinako, $e author. $3 3770533
245 1 0 $a Investigating the Role of the Gut Microbiome and the Gut Metabolome in the Development of Childhood Eczema and Asthma / $c Hinako Terauchi.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (234 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
500 $a Advisors: Mansfield, Linda S. Committee members: Manning, Shannon D.; Zhang, Lixin; Ewart, Susan L.; Yuzbasiyan-Gurkan, Vilma.
502 $b Ph.D. $c Michigan State University $d 2024.
520 $a In United States alone, more than 1 in 4 children are diagnosed with some form of allergy, yet the exact etiology of allergy development in childhood is unknown. Many factors have been associated with this rise in such disorders including genetics, epigenetics, environmental toxins and particulates, as well as the microbiota. The host microbiome has been associated with a multitude of human and animal diseases, disorders, and conditions. Its involvement in the atopic and autoimmune disorders is an every-growing field of new knowledge. In this work, I explore the effect of the gut microbiome on allergy, specifically childhood eczema and asthma, using samples and data collected from the Isle of Wight allergy study cohort as well as a fecal-transplanted humanized microbiota mouse models. In addition, measured specific gut metabolites that were significant in distinguishing between the pathology phenotypes in both study sets will be discussed. In chapter 1, I explored the gut bacterial microbiota of infants in the Isle of Wight allergy study cohort and their association with their development in eczema. We also explored bacterial taxa previously shown in published work to be associated with allergy as agonists or antagonists. Subsequent statistical analyses including random forest and logistic regressions supported these findings and results from logistic regressions provide statistical significance for the association of eczema status at age 3 months with the relative abundance of genus Veillonella at that age. In chapter 2, a study conducted using a mouse model of asthma created by fecal transplantation of the infants featured in chapter 1, connection between gut microbiota in infancy and lung baseline responses were studied and supported. In chapter 4, the role of the gut metabolome in the development of allergic phenotype was explored using the samples from both chapters 1 and 2, where it was shown that infants with allergic phenotype have a distinct gut metabolomic profile compared to infants without allergic phenotype; and mice with reduced lung functionality expressed a distinct gut metabolic profiles compared to mice without reduced lung functionality. Overall, these studies confirmed previously associated relationship between specific bacterial taxa and allergy using a unique infant cohort as well as an original mouse model, while also providing new points of interest to further deepen the understanding of the relationship and the interaction between the gut contents and the host's development of allergy.
546 $a English
590 $a School code: 0128
650 4 $a Microbiology. $3 536250
650 4 $a Pathology. $3 643180
650 4 $a Molecular biology. $3 517296
650 4 $a Biochemistry. $3 518028
653 $a Childhood eczema
653 $a Allergy development
653 $a Asthma
653 $a Eczema
653 $a Gut metabolome
653 $a Bacterial taxa
690 $a 0410
690 $a 0487
690 $a 0307
690 $a 0571
710 2 $a Michigan State University. $b Microbiology and Molecular Genetics - Doctor of Philosophy. $e degree granting institution. $3 3770534
720 1 $a Mansfield, Linda S. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-07B.
790 $a 0128
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30813549