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The Role of the Posterior Intralamin...

Leithead, Amanda Beth.

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The Role of the Posterior Intralaminar Complex of the Thalamus in Social Behavior.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Role of the Posterior Intralaminar Complex of the Thalamus in Social Behavior./
作者:	Leithead, Amanda Beth.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	99 p.
附註:	Source: Dissertations Abstracts International, Volume: 84-10, Section: B.
Contained By:	Dissertations Abstracts International84-10B.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30418891
ISBN:	9798379414160

The Role of the Posterior Intralaminar Complex of the Thalamus in Social Behavior.
Leithead, Amanda Beth.

The Role of the Posterior Intralaminar Complex of the Thalamus in Social Behavior. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 99 p.

Source: Dissertations Abstracts International, Volume: 84-10, Section: B.

Thesis (Ph.D.)--Icahn School of Medicine at Mount Sinai, 2023.

The posterior intralaminar (PIL) complex of the thalamus is a multimodal nucleus that has been primarily implicated in maternal behaviors, where it is hypothesized to function as a relay nucleus which transmits somatosensory and auditory information to hypothalamic nuclei for the expression of social behaviors and neuropeptide release. We performed a series of viral anterograde and retrograde tracing studies involving the PIL to confirm, in mice, the existence of inputs from sensory regions and projections to brain regions involved in social behaviors. Further, we provide evidence that PIL neurons projecting to the paraventricular hypothalamus (PVH) express glutamate, but not GABA, thereby suggesting the importance of glutamatergic activity within the PIL. We used immunohistochemistry for the immediate early gene c-fos as a proxy for neuronal activity in the PIL of mice exposed to a novel social stimulus, novel object stimulus, or no stimulus and observed significantly more c-fos-positive cells in the PIL of mice exposed to social versus object or no stimuli. We then used fiber photometry to record neural activity of glutamatergic neurons in the PIL in real-time during social and non-social interactions. Neural activity of PIL glutamatergic neurons was increased when male and female mice were engaged in social interaction with a same-sex juvenile or opposite-sex adult, but not a toy mouse. Further, during bouts of social investigation, neural activity positively correlated with investigation bout length and negatively correlated with chronological order of investigation bouts. PIL glutamatergic activity also increased in response to a social odor (opposite-sex urine) in females but not in males. Finally, we used inhibitory DREADDs in glutamatergic neurons of the PIL and tested social approach, social preference and social habituation-dishabituation. Social approach and preference were unaffected by inhibition; however, suppressing glutamatergic activity in the PIL delayed the time it took female mice to form social habituation. Together these findings suggest that glutamatergic PIL neurons respond to social stimuli in both male and female mice and may regulate the perceptual encoding of social information to facilitate recognition of social stimuli.

ISBN: 9798379414160Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Posterior intralaminar

The Role of the Posterior Intralaminar Complex of the Thalamus in Social Behavior.
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