東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Post-Mitotic Reformation of the Nucl...

Vargas, Jesse.

FindBook

Google Book

Amazon

博客來

Post-Mitotic Reformation of the Nuclear Envelope and Aberrant Nuclear Envelope Rupturing During Interphase in Human Cancer Cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Post-Mitotic Reformation of the Nuclear Envelope and Aberrant Nuclear Envelope Rupturing During Interphase in Human Cancer Cells./
作者:	Vargas, Jesse.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
面頁冊數:	141 p.
附註:	Source: Dissertations Abstracts International, Volume: 74-03, Section: B.
Contained By:	Dissertations Abstracts International74-03B.
標題:	Molecular biology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3519101
ISBN:	9781267517210

Post-Mitotic Reformation of the Nuclear Envelope and Aberrant Nuclear Envelope Rupturing During Interphase in Human Cancer Cells.
Vargas, Jesse.

Post-Mitotic Reformation of the Nuclear Envelope and Aberrant Nuclear Envelope Rupturing During Interphase in Human Cancer Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 141 p.

Source: Dissertations Abstracts International, Volume: 74-03, Section: B.

Thesis (Ph.D.)--University of California, San Diego, 2012.

.

The nucleus, defined by its enclosing boundary, the nuclear envelope, is the largest organelle in most eukaryotic cells and houses the nuclear genome. It has been implicated in various physiological processes crucial to normal cell function, processes that are often altered in disease. Here we show that the re-establishment of this critical organelle after cellular division is achieved by a co-opting of numerous proteins of the inner nuclear membrane that interact with DNA/chromatin and that each serve distinct interphase functions. That such a large number of proteins and resources are dedicated to the rapid reformation of the nuclear envelope and proper nuclear compartmentalization suggests its critical importance for normal cell function. Subsequently, we show that this barrier function and the integrity of the nuclear envelope is transiently disrupted in human cancer cells, leading to the mislocalization of both nuclear and cytoplasmic proteins. In extreme cases, this loss of integrity leads to a partial loss of cellular compartmentalization, with normally cytoplasmic organelles appearing in the interior of the cell nucleus. These rupture events are transient and recoverable, but the efflux of genomic material from the nucleus during such events suggests potential genomic insult that may contribute to alterations in genetic information and to the transformation process in cancer.

ISBN: 9781267517210Subjects--Topical Terms:

517296
Molecular biology.
Subjects--Index Terms:

Cancer cells

Post-Mitotic Reformation of the Nuclear Envelope and Aberrant Nuclear Envelope Rupturing During Interphase in Human Cancer Cells.
LDR:02852nmm a2200457 4500 001 2400017
005 20240916070043.5
006 m o d
007 cr#unu||||||||
008 251215s2012 ||||||||||||||||| ||eng d
020 $a 9781267517210
035 $a (MiAaPQ)AAI3519101
035 $a (MiAaPQ)ucsd:12411
035 $a AAI3519101
040 $a MiAaPQ $c MiAaPQ
100 1 $a Vargas, Jesse. $3 3769988
245 1 0 $a Post-Mitotic Reformation of the Nuclear Envelope and Aberrant Nuclear Envelope Rupturing During Interphase in Human Cancer Cells.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2012
300 $a 141 p.
500 $a Source: Dissertations Abstracts International, Volume: 74-03, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Includes supplementary digital materials.
500 $a Advisor: Hetzer, Martin W.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2012.
506 $a .
520 $a The nucleus, defined by its enclosing boundary, the nuclear envelope, is the largest organelle in most eukaryotic cells and houses the nuclear genome. It has been implicated in various physiological processes crucial to normal cell function, processes that are often altered in disease. Here we show that the re-establishment of this critical organelle after cellular division is achieved by a co-opting of numerous proteins of the inner nuclear membrane that interact with DNA/chromatin and that each serve distinct interphase functions. That such a large number of proteins and resources are dedicated to the rapid reformation of the nuclear envelope and proper nuclear compartmentalization suggests its critical importance for normal cell function. Subsequently, we show that this barrier function and the integrity of the nuclear envelope is transiently disrupted in human cancer cells, leading to the mislocalization of both nuclear and cytoplasmic proteins. In extreme cases, this loss of integrity leads to a partial loss of cellular compartmentalization, with normally cytoplasmic organelles appearing in the interior of the cell nucleus. These rupture events are transient and recoverable, but the efflux of genomic material from the nucleus during such events suggests potential genomic insult that may contribute to alterations in genetic information and to the transformation process in cancer.
590 $a School code: 0033.
650 4 $a Molecular biology. $3 517296
650 4 $a Cellular biology. $3 3172791
650 4 $a Oncology. $3 751006
653 $a Cancer cells
653 $a Inner nuclear membrane protein
653 $a Lamin
653 $a Nuclear envelope formation
653 $a Nuclear integrity
653 $a Nuclear rupture
653 $a Nucleus
690 $a 0307
690 $a 0379
690 $a 0992
710 2 $a University of California, San Diego. $b Biology. $3 1020228
773 0 $t Dissertations Abstracts International $g 74-03B.
790 $a 0033
791 $a Ph.D.
792 $a 2012
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3519101