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Effect of molecular weight of polyet...

Rezaei, Hamid.

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Effect of molecular weight of polyethylene glycols on their function as lubricant sparing binders in tablet technology.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effect of molecular weight of polyethylene glycols on their function as lubricant sparing binders in tablet technology./
Author:	Rezaei, Hamid.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2001,
Description:	182 p.
Notes:	Source: Dissertations Abstracts International, Volume: 62-12, Section: B.
Contained By:	Dissertations Abstracts International62-12B.
Subject:	Pharmaceuticals. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3002650
ISBN:	9780493114415

Effect of molecular weight of polyethylene glycols on their function as lubricant sparing binders in tablet technology.
Rezaei, Hamid.

Effect of molecular weight of polyethylene glycols on their function as lubricant sparing binders in tablet technology. - Ann Arbor : ProQuest Dissertations & Theses, 2001 - 182 p.

Source: Dissertations Abstracts International, Volume: 62-12, Section: B.

Thesis (Ph.D.)--University of Cincinnati, 2001.

The objective of this study was to determine the effect of molecular weight on the function of polyethylene glycols (PEGs) as lubricant sparing binders in tabletting technology. Compression-force and ejection-force profiles were obtained using an instrumented Manesty D3B rotary tablet press. In order to determine the lubricating mechanism of PEGs, after storage in controlled settings, PEGs of different molecular weight were compressed. PEG-8000 resulted in compacts with the greatest crushing strength, PEG-3350 next, and PEG-20M last. Scanning electron microscopy showed, while PEG-20M compacted by plastic deformation, both PEG-3350, and PEG-8000 had compacted by brittle fracture, with evidence of melting during compression. It was concluded that lubrication properties of PEG-20M was due to its plastic deformation properties. PEGs were also studied for their binding mechanism. A full factorial experimental design using three binder levels and three compression forces, using 0.5% magnesium stearate was utilized. Low-shear wet granulation, high-shear wet granulation, and roller-compaction were utilized using acetaminophen as the model drug. Tablets with a target weight of 310 mg were compressed using 9mm shallow concave punches at 19 RPM. ANOVA was used to analyze the results based on the PEG molecular weight, levels, and compression force (P ≤ 0.05). PEG-20M proved to be the superior binder to all other polyethylene glycol binders using all three manufacturing methods, and comparable or superior to povidone. PEG-20M produced tablets with lower friability than PEG-8000 and PEG-3350. It also resulted in tablets with the highest dissolution rate for acetaminophen, including the reference binder. PEG-20M resulted in tablets with acceptable friability using low-shear and high-shear wet granulation, and roller compaction with significantly lower tablet ejection forces than other polyethylene glycols or povidone. It was concluded that PEG-20M is a unique molecule, with higher porosity, and flexibility than lower molecular weight PEGs. It is only a better binder than other PEGs, but also enhances the dissolution of acetaminophen, a poorly soluble drug (channeling agent). Under the conditions studied, PEG-20M had the best "binder efficiency", granule size flow and homogeneity, and tablet crushing strength friability and dissolution results.

ISBN: 9780493114415Subjects--Topical Terms:

3562593
Pharmaceuticals.
Subjects--Index Terms:

Lubricant sparing binders

Effect of molecular weight of polyethylene glycols on their function as lubricant sparing binders in tablet technology.
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300 $a 182 p.
500 $a Source: Dissertations Abstracts International, Volume: 62-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
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502 $a Thesis (Ph.D.)--University of Cincinnati, 2001.
520 $a The objective of this study was to determine the effect of molecular weight on the function of polyethylene glycols (PEGs) as lubricant sparing binders in tabletting technology. Compression-force and ejection-force profiles were obtained using an instrumented Manesty D3B rotary tablet press. In order to determine the lubricating mechanism of PEGs, after storage in controlled settings, PEGs of different molecular weight were compressed. PEG-8000 resulted in compacts with the greatest crushing strength, PEG-3350 next, and PEG-20M last. Scanning electron microscopy showed, while PEG-20M compacted by plastic deformation, both PEG-3350, and PEG-8000 had compacted by brittle fracture, with evidence of melting during compression. It was concluded that lubrication properties of PEG-20M was due to its plastic deformation properties. PEGs were also studied for their binding mechanism. A full factorial experimental design using three binder levels and three compression forces, using 0.5% magnesium stearate was utilized. Low-shear wet granulation, high-shear wet granulation, and roller-compaction were utilized using acetaminophen as the model drug. Tablets with a target weight of 310 mg were compressed using 9mm shallow concave punches at 19 RPM. ANOVA was used to analyze the results based on the PEG molecular weight, levels, and compression force (P ≤ 0.05). PEG-20M proved to be the superior binder to all other polyethylene glycol binders using all three manufacturing methods, and comparable or superior to povidone. PEG-20M produced tablets with lower friability than PEG-8000 and PEG-3350. It also resulted in tablets with the highest dissolution rate for acetaminophen, including the reference binder. PEG-20M resulted in tablets with acceptable friability using low-shear and high-shear wet granulation, and roller compaction with significantly lower tablet ejection forces than other polyethylene glycols or povidone. It was concluded that PEG-20M is a unique molecule, with higher porosity, and flexibility than lower molecular weight PEGs. It is only a better binder than other PEGs, but also enhances the dissolution of acetaminophen, a poorly soluble drug (channeling agent). Under the conditions studied, PEG-20M had the best "binder efficiency", granule size flow and homogeneity, and tablet crushing strength friability and dissolution results.
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650 4 $a Pharmaceutical sciences. $3 3173021
653 $a Lubricant sparing binders
653 $a Molecular weight
653 $a Polyethylene glycols
653 $a Tablet
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710 2 $a University of Cincinnati. $3 960309
773 0 $t Dissertations Abstracts International $g 62-12B.
790 $a 0045
791 $a Ph.D.
792 $a 2001
793 $a English
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