東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Single Neuron and Population Spiking...

Hassan, Ahnaf Rashik.

FindBook

Google Book

Amazon

博客來

Single Neuron and Population Spiking Dynamics in Physiologic and Pathologic Memory Processing.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Single Neuron and Population Spiking Dynamics in Physiologic and Pathologic Memory Processing./
作者:	Hassan, Ahnaf Rashik.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
面頁冊數:	120 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-10, Section: B.
Contained By:	Dissertations Abstracts International85-10B.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31234537
ISBN:	9798382261188

Single Neuron and Population Spiking Dynamics in Physiologic and Pathologic Memory Processing.
Hassan, Ahnaf Rashik.

Single Neuron and Population Spiking Dynamics in Physiologic and Pathologic Memory Processing. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 120 p.

Source: Dissertations Abstracts International, Volume: 85-10, Section: B.

Thesis (Ph.D.)--Columbia University, 2024.

Cognitive processes in the human brain are mediated by complex interactions among distributed brain regions. The interaction between the hippocampus and neocortical regions is crucial for physiologic and pathologic long-term episodic memory processing in the brain. However, the network mechanisms of this hippocampal-cortical communication remain unclear. To address this issue, we first designed organic materials and conformable electronics to create integrated neural interface devices that increase the spatiotemporal resolution of electrophysiologic monitoring. These devices enabled acquisition of local field potentials and action potentials of individual cortical neurons from the surface of the human brain, enhancing the ability to investigate neural network mechanisms without breaching the tissue interface. Next, we employed these devices in tandem with hippocampal probes to analyze hippocampal-cortical interactions in the context of memory tasks in freely moving rodents. We determined that in the physiologic state, the spatial properties of cortical spindle oscillations predict the likelihood of coupling with hippocampal ripples and are modulated by memory demand. In the pathologic state, we showed that interictal epileptiform discharges (IEDs), ubiquitous markers of epileptic networks, disrupt hippocampal-cortical coupling required for memory consolidation. These IEDs induce spindle oscillations in the synaptically connected cortex, producing prolonged, hypersynchronous neuronal spiking and expanding the brain territory capable of generating IEDs. Spatiotemporally targeted closed-loop electrical stimulation triggered on hippocampal IED occurrence eliminated the abnormal cortical activity patterns, preventing spread of the epileptic network and ameliorating long-term spatial memory deficits in rodents. Our findings provide new insights into mechanisms of physiologic and pathologic memory processing and offer novel approaches to therapies aimed at addressing distributed network dysfunction in neuropsychiatric disorders.

ISBN: 9798382261188Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Action potentials

Single Neuron and Population Spiking Dynamics in Physiologic and Pathologic Memory Processing.
LDR:03225nmm a2200397 4500 001 2399784
005 20240916070009.5
006 m o d
007 cr#unu||||||||
008 251215s2024 ||||||||||||||||| ||eng d
020 $a 9798382261188
035 $a (MiAaPQ)AAI31234537
035 $a AAI31234537
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hassan, Ahnaf Rashik. $3 3434187
245 1 0 $a Single Neuron and Population Spiking Dynamics in Physiologic and Pathologic Memory Processing.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 120 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-10, Section: B.
500 $a Advisor: Gelinas, Jennifer N.
502 $a Thesis (Ph.D.)--Columbia University, 2024.
520 $a Cognitive processes in the human brain are mediated by complex interactions among distributed brain regions. The interaction between the hippocampus and neocortical regions is crucial for physiologic and pathologic long-term episodic memory processing in the brain. However, the network mechanisms of this hippocampal-cortical communication remain unclear. To address this issue, we first designed organic materials and conformable electronics to create integrated neural interface devices that increase the spatiotemporal resolution of electrophysiologic monitoring. These devices enabled acquisition of local field potentials and action potentials of individual cortical neurons from the surface of the human brain, enhancing the ability to investigate neural network mechanisms without breaching the tissue interface. Next, we employed these devices in tandem with hippocampal probes to analyze hippocampal-cortical interactions in the context of memory tasks in freely moving rodents. We determined that in the physiologic state, the spatial properties of cortical spindle oscillations predict the likelihood of coupling with hippocampal ripples and are modulated by memory demand. In the pathologic state, we showed that interictal epileptiform discharges (IEDs), ubiquitous markers of epileptic networks, disrupt hippocampal-cortical coupling required for memory consolidation. These IEDs induce spindle oscillations in the synaptically connected cortex, producing prolonged, hypersynchronous neuronal spiking and expanding the brain territory capable of generating IEDs. Spatiotemporally targeted closed-loop electrical stimulation triggered on hippocampal IED occurrence eliminated the abnormal cortical activity patterns, preventing spread of the epileptic network and ameliorating long-term spatial memory deficits in rodents. Our findings provide new insights into mechanisms of physiologic and pathologic memory processing and offer novel approaches to therapies aimed at addressing distributed network dysfunction in neuropsychiatric disorders.
590 $a School code: 0054.
650 4 $a Neurosciences. $3 588700
650 4 $a Biomedical engineering. $3 535387
650 4 $a Pathology. $3 643180
650 4 $a Cognitive psychology. $3 523881
653 $a Action potentials
653 $a Bioelectronics
653 $a Epilepsy
653 $a Hippocampus
653 $a Memory
690 $a 0317
690 $a 0541
690 $a 0633
690 $a 0571
710 2 $a Columbia University. $b Biomedical Engineering. $3 2100333
773 0 $t Dissertations Abstracts International $g 85-10B.
790 $a 0054
791 $a Ph.D.
792 $a 2024
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31234537