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The Effects of Prenatal and Perinata...

Schaeffer, Ericka Ann.

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The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior./
Author:	Schaeffer, Ericka Ann.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	116 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
Subject:	Neurosciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30640346
ISBN:	9798381427981

The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior.
Schaeffer, Ericka Ann.

The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 116 p.

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

Thesis (Ph.D.)--Northern Illinois University, 2023.

Prenatal alcohol exposure (PAE) is a prevalent phenomenon conserved across cultures which can result in a heterogeneous set of symptoms associated with offspring development. Although there is much research characterizing the extent of disruptions in spatial and motor performance, there appears to be conflicting results dependent on the type of PAE model. Therefore, the current study aimed to investigate a more reliable and translatable model of symptoms associated with fetal alcohol syndrome disorders. The current set of experiments evaluated the effects of alcohol exposure in mice during prenatal (gestation day 4-18) and early postnatal (postnatal day 4-12) development on organization of spatial and gross motor behavior in adulthood. Results indicate spatial orientation and gait are spared; however, a dissociation in anxiety measures was observed between exposure timepoints, which was dependent on sex. Specially, PAE males and PrAE females were observed to display more behaviors indicative of anxiety. Additionally, the organization of spatial and gait behaviors appears to be spared. Future research should continue to develop translatable models of PAE as well as aiding in early detection of subtle symptoms.

ISBN: 9798381427981Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Prenatal alcohol exposure

The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior.
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245 1 0 $a The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 116 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
500 $a Advisor: Wallace, Doug G.
502 $a Thesis (Ph.D.)--Northern Illinois University, 2023.
520 $a Prenatal alcohol exposure (PAE) is a prevalent phenomenon conserved across cultures which can result in a heterogeneous set of symptoms associated with offspring development. Although there is much research characterizing the extent of disruptions in spatial and motor performance, there appears to be conflicting results dependent on the type of PAE model. Therefore, the current study aimed to investigate a more reliable and translatable model of symptoms associated with fetal alcohol syndrome disorders. The current set of experiments evaluated the effects of alcohol exposure in mice during prenatal (gestation day 4-18) and early postnatal (postnatal day 4-12) development on organization of spatial and gross motor behavior in adulthood. Results indicate spatial orientation and gait are spared; however, a dissociation in anxiety measures was observed between exposure timepoints, which was dependent on sex. Specially, PAE males and PrAE females were observed to display more behaviors indicative of anxiety. Additionally, the organization of spatial and gait behaviors appears to be spared. Future research should continue to develop translatable models of PAE as well as aiding in early detection of subtle symptoms.
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650 4 $a Behavioral sciences. $3 529833
650 4 $a Physiological psychology. $3 2144820
653 $a Prenatal alcohol exposure
653 $a Fetal alcohol syndrome disorders
653 $a Adulthood
653 $a Gross motor behavior
653 $a Motor performance
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690 $a 0602
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710 2 $a Northern Illinois University. $b Psychology. $3 1024156
773 0 $t Dissertations Abstracts International $g 85-07B.
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