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Exercise Modifies the Brain Metaboli...

Hanna, Colin S.

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Exercise Modifies the Brain Metabolic Response to Cocaine Exposure.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Exercise Modifies the Brain Metabolic Response to Cocaine Exposure./
作者:	Hanna, Colin S.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	45 p.
附註:	Source: Masters Abstracts International, Volume: 84-12.
Contained By:	Masters Abstracts International84-12.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30492349
ISBN:	9798379734961

Exercise Modifies the Brain Metabolic Response to Cocaine Exposure.
Hanna, Colin S.

Exercise Modifies the Brain Metabolic Response to Cocaine Exposure. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 45 p.

Source: Masters Abstracts International, Volume: 84-12.

Thesis (M.S.)--State University of New York at Buffalo, 2023.

Exercise is well known to promote health and wellness. It has been shown to play a protective role in many diseases including cardiovascular, neurological, and psychiatric diseases. The following experiments examined the effects of aerobic exercise on brain glucose metabolism (BGluM), including the response to acute and chronic cocaine exposure in rats. Using Positron Emission Tomography (PET) and [18F]-Fluorodeoxyglucose (FDG), metabolic changes in distinct brain regions were observed when comparing exercised rats to sedentary rats in all three conditions. Exercise produced significant BGluM activation in the caudate putamen (striatum), primary auditory cortex, postsubiculum, subiculum, and the central nucleus of the inferior colliculus. Acute cocaine treatment resulted in significant BGluM activation of the postsubiculum, parasubiculum, insular cortex, substantia nigra, temporal association cortex, and crus 1 of the cerebellum. BGluM inhibition was also observed in the endopiriform nucleus (VEn). Chronic cocaine treatment resulted in BGluM activation of the secondary visual cortex, and inhibition in the cerebellum, stria terminalis, thalamus, caudate putamen, and primary somatosensory cortex. The functional network of these brain circuits are involved in memory, sensory processing, fear/stress responses, reward/addiction, and movement. These results show that aerobic exercise can alter the brain metabolic response to cocaine exposure in distinct regions, thus altering brains response to cocaine. These findings support previous data of the potential for aerobic exercise to have therapeutic potential for drug abuse by modifying activity in regions associated with reward and movement. Finally, these results provide a brain circuit and targets for future molecular investigation into the mechanism of how exercise might protect or attenuate risk for addiction. 

ISBN: 9798379734961Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Brain metabolic response

Exercise Modifies the Brain Metabolic Response to Cocaine Exposure.
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