東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Photothermal therapies using near in...

Gobin, Andre Mathura,

Linked to FindBook

Google Book

Amazon

博客來

Photothermal therapies using near infrared absorbing nanoparticles /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Photothermal therapies using near infrared absorbing nanoparticles // Andre Mathura Gobin.
Author:	Gobin, Andre Mathura,
Description:	1 electronic resource (181 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 70-10, Section: B.
Contained By:	Dissertations Abstracts International70-10B.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3309877
ISBN:	9780549579434

Photothermal therapies using near infrared absorbing nanoparticles /
Gobin, Andre Mathura,

Photothermal therapies using near infrared absorbing nanoparticles /Andre Mathura Gobin. - 1 electronic resource (181 pages)

Source: Dissertations Abstracts International, Volume: 70-10, Section: B.

This thesis describes the development of new infrared (NIR) absorbing nanoparticles for use in biomedical therapeutic applications. Gold nanoshells with a dielectric core of silica developed at Rice University have shown tunable optical properties, these and nanoshells with a gold sulfide core are exploited in this thesis to develop several therapeutic applications. These applications include bonding of tissues, integrated imaging and therapy for cancer applications and targeted destruction of cancer tumor cells to improve on the efficacy of photothermal therapy using nanoshells. In addition, the development of nanoshells with a gold sulfide core and a gold shell are utilized for therapeutic application similarly to gold-silica nanoshells. These gold-gold sulfide nanoshells are attractive for use as a therapeutic agent because their size makes them more efficient at absorbing light energy and converting it to heat, allowing them to achieve higher temperatures faster than gold-silica nanoshells. In addition, the smaller size allows them to circulate longer in vivo and could allow them to be delivered more efficiently into tumors. The use of nanoshells to replace indocyanine green (ICG), an FDA approved exogenous chromophore, in tissue welding application shows great promise in vivo. Nanoshells were successfully targeted against prostate cancer cells by using antibodies against surface marker Prostate Specific Membrane Antigen (PSMA) anchored to the cell surface which are over-expressed in the more aggressive prostate malignancies. Additionally, nanoshells were targeted against the less aggressive prostate tumor line using EphrinA1, a ligand which binds to the Eph A2 receptor over-expressed on prostate tumor cells. Both of these approaches show excellent binding and destruction of cells in vitro. A single nanoshell was developed which have both scattering and absorbing properties and was shown to be effective at allowing imaging of tumors and subsequent destruction. These nanoshells provided a 56% improvement in imaging contrast and 82% survival in vivo. Finally, gold-gold sulfide nanoshells are developed and it is shown that they can achieve higher temperatures faster than gold-silica nanoshells at the same optical densities and laser energies. Tumor bearing treated with these nanoshells show complete tumor regression in vivo .

English

ISBN: 9780549579434Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Absorbing nanoparticles

Photothermal therapies using near infrared absorbing nanoparticles /
LDR:03709nmm a22004093i 4500 001 2396216
005 20250522083212.5
006 m o d
007 cr|nu||||||||
008 251215s2007 miu||||||m |||||||eng d
020 $a 9780549579434
035 $a (MiAaPQD)AAI3309877
035 $a AAI3309877
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Gobin, Andre Mathura, $e author. $3 3765860
245 1 0 $a Photothermal therapies using near infrared absorbing nanoparticles / $c Andre Mathura Gobin.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2007
300 $a 1 electronic resource (181 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 70-10, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisors: West, Jennifer.
502 $b Ph.D. $c Rice University $d 2007.
520 $a This thesis describes the development of new infrared (NIR) absorbing nanoparticles for use in biomedical therapeutic applications. Gold nanoshells with a dielectric core of silica developed at Rice University have shown tunable optical properties, these and nanoshells with a gold sulfide core are exploited in this thesis to develop several therapeutic applications. These applications include bonding of tissues, integrated imaging and therapy for cancer applications and targeted destruction of cancer tumor cells to improve on the efficacy of photothermal therapy using nanoshells. In addition, the development of nanoshells with a gold sulfide core and a gold shell are utilized for therapeutic application similarly to gold-silica nanoshells. These gold-gold sulfide nanoshells are attractive for use as a therapeutic agent because their size makes them more efficient at absorbing light energy and converting it to heat, allowing them to achieve higher temperatures faster than gold-silica nanoshells. In addition, the smaller size allows them to circulate longer in vivo and could allow them to be delivered more efficiently into tumors. The use of nanoshells to replace indocyanine green (ICG), an FDA approved exogenous chromophore, in tissue welding application shows great promise in vivo. Nanoshells were successfully targeted against prostate cancer cells by using antibodies against surface marker Prostate Specific Membrane Antigen (PSMA) anchored to the cell surface which are over-expressed in the more aggressive prostate malignancies. Additionally, nanoshells were targeted against the less aggressive prostate tumor line using EphrinA1, a ligand which binds to the Eph A2 receptor over-expressed on prostate tumor cells. Both of these approaches show excellent binding and destruction of cells in vitro. A single nanoshell was developed which have both scattering and absorbing properties and was shown to be effective at allowing imaging of tumors and subsequent destruction. These nanoshells provided a 56% improvement in imaging contrast and 82% survival in vivo. Finally, gold-gold sulfide nanoshells are developed and it is shown that they can achieve higher temperatures faster than gold-silica nanoshells at the same optical densities and laser energies. Tumor bearing treated with these nanoshells show complete tumor regression in vivo .
546 $a English
590 $a School code: 0187
650 4 $a Biomedical engineering. $3 535387
650 4 $a Biophysics. $3 518360
653 $a Absorbing nanoparticles
653 $a Gold nanoshells
653 $a Photothermal therapies
690 $a 0541
690 $a 0786
710 2 $a Rice University. $e degree granting institution. $3 3765730
720 1 $a West, Jennifer $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 70-10B.
790 $a 0187
791 $a Ph.D.
792 $a 2007
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3309877