東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Microbial Natural Product Drug Disco...

Currens, Grant C.,

Linked to FindBook

Google Book

Amazon

博客來

Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils // Grant C Currens.
Author:	Currens, Grant C.,
Description:	1 electronic resource (142 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-04, Section: B.
Contained By:	Dissertations Abstracts International83-04B.
Subject:	Pharmaceutical sciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28649524
ISBN:	9798460472284

Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils /
Currens, Grant C.,

Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils /Grant C Currens. - 1 electronic resource (142 pages)

Source: Dissertations Abstracts International, Volume: 83-04, Section: B.

This project aimed to explore a new approach to microbial natural product discovery through collection of soil samples from strategically determined geographic sites in the State of Texas. Morphologically distinctive bacterial and fungal isolates were obtained from the soil samples and a pilot-size, semi-fractionated natural product library was constructed and screened for cytotoxicity against human cancer cell lines. Subsequently, activity-guided purification and structural identification were performed to characterize naturally occurring bioactive small molecules.Through a pilot fungal-derived natural product study, the library construction methodology was validated and known cytotoxic compounds malformin, palmitic acid, aspergillin PZ, and trichoderone B were isolated and re-identified. Their structural data and previously unknown cytotoxicity against various cancer cell lines were studied and are reported herein.

English

ISBN: 9798460472284Subjects--Topical Terms:

3173021
Pharmaceutical sciences.
Subjects--Index Terms:

Drug Discovery

Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils /
LDR:02286nmm a22003973i 4500 001 2396123
005 20250522083153.5
006 m o d
007 cr|nu||||||||
008 251215s2021 miu||||||m |||||||eng d
020 $a 9798460472284
035 $a (MiAaPQD)AAI28649524
035 $a AAI28649524
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Currens, Grant C., $e author. $3 3765690
245 1 0 $a Microbial Natural Product Drug Discovery Through Systematic Sampling of Diverse Texas Soils / $c Grant C Currens.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 1 electronic resource (142 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 83-04, Section: B.
500 $a Advisors: Cheng, Eric Y.
502 $b Ph.D. $c University of North Texas Health Science Center at Fort Worth $d 2021.
520 $a This project aimed to explore a new approach to microbial natural product discovery through collection of soil samples from strategically determined geographic sites in the State of Texas. Morphologically distinctive bacterial and fungal isolates were obtained from the soil samples and a pilot-size, semi-fractionated natural product library was constructed and screened for cytotoxicity against human cancer cell lines. Subsequently, activity-guided purification and structural identification were performed to characterize naturally occurring bioactive small molecules.Through a pilot fungal-derived natural product study, the library construction methodology was validated and known cytotoxic compounds malformin, palmitic acid, aspergillin PZ, and trichoderone B were isolated and re-identified. Their structural data and previously unknown cytotoxicity against various cancer cell lines were studied and are reported herein.
546 $a English
590 $a School code: 1250
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Microbiology. $3 536250
653 $a Drug Discovery
653 $a Microbial Natural Products
653 $a Natural Product Library
690 $a 0572
690 $a 0410
710 2 $a University of North Texas Health Science Center at Fort Worth. $b Biomedical Sciences. $e degree granting institution. $3 3765691
720 1 $a Cheng, Eric Y. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 83-04B.
790 $a 1250
791 $a Ph.D.
792 $a 2021
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28649524