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Microfluidic Engineering of On-Chip ...

Wu, Yue.

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Microfluidic Engineering of On-Chip Vascular Models for Preclinical Biomedical Investigation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Microfluidic Engineering of On-Chip Vascular Models for Preclinical Biomedical Investigation./
Author:	Wu, Yue.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	78 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30815227
ISBN:	9798381378030

Microfluidic Engineering of On-Chip Vascular Models for Preclinical Biomedical Investigation.
Wu, Yue.

Microfluidic Engineering of On-Chip Vascular Models for Preclinical Biomedical Investigation. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 78 p.

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

Thesis (Ph.D.)--Lehigh University, 2024.

This item must not be sold to any third party vendors.

Vascular system is involved in various essential life activities, including both normal embryonic organ development and pathological processes, such as tumorigenesis. In addition to exchanging nutrients, oxygen, and metabolites with organs, blood vessels are also involved in many important immune responses and signaling pathways. In recent years, microfluidic chips and organoid technologies have become more and more advanced, and small-dimensional organ tissues can be replicated in vitro for regenerative medicine development and drug candidate screening research. However, without timely vascularization, the organ tissue at a certain size will develop a necrotic inner core, causing overall apoptosis finally. Therefore, understanding vascular biology and rational introduction of vascular structures in the microenvironment is particularly important for reproducing realistic functional tissue models.Here, we report three different forms of microfluidic vascular models for periclinal physiological investigation research and drug screening purpose, respectively. In chapter 1, a blood vessel lumen with hundreds of microns in diameter was constructed on microfluidic chip to study the vessel-circulating tumor cells (CTCs) interaction during cancer metastasis. In chapter 2, on-chip capillary micro vessel network was restored to support microfluidic droplet-fabricated tumor spheroids, enabling high-fidelity restoration of the tumor microenvironment and high-throughput preclinical drug screening. In chapter 3, acoustofluidic patterning is presented for on-demand and facile engineering of the in vitro vessel model in a high-resolution manner.

ISBN: 9798381378030Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Acoustofluidics

Microfluidic Engineering of On-Chip Vascular Models for Preclinical Biomedical Investigation.
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520 $a Vascular system is involved in various essential life activities, including both normal embryonic organ development and pathological processes, such as tumorigenesis. In addition to exchanging nutrients, oxygen, and metabolites with organs, blood vessels are also involved in many important immune responses and signaling pathways. In recent years, microfluidic chips and organoid technologies have become more and more advanced, and small-dimensional organ tissues can be replicated in vitro for regenerative medicine development and drug candidate screening research. However, without timely vascularization, the organ tissue at a certain size will develop a necrotic inner core, causing overall apoptosis finally. Therefore, understanding vascular biology and rational introduction of vascular structures in the microenvironment is particularly important for reproducing realistic functional tissue models.Here, we report three different forms of microfluidic vascular models for periclinal physiological investigation research and drug screening purpose, respectively. In chapter 1, a blood vessel lumen with hundreds of microns in diameter was constructed on microfluidic chip to study the vessel-circulating tumor cells (CTCs) interaction during cancer metastasis. In chapter 2, on-chip capillary micro vessel network was restored to support microfluidic droplet-fabricated tumor spheroids, enabling high-fidelity restoration of the tumor microenvironment and high-throughput preclinical drug screening. In chapter 3, acoustofluidic patterning is presented for on-demand and facile engineering of the in vitro vessel model in a high-resolution manner.
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