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Low-Power and Miniaturized Medical Electronics for In-Vivo Localization and Tracking.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Low-Power and Miniaturized Medical Electronics for In-Vivo Localization and Tracking./
作者:	Sharma, Saransh.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	231 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
Contained By:	Dissertations Abstracts International85-03B.
標題:	Barium. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30604365
ISBN:	9798380267595

Low-Power and Miniaturized Medical Electronics for In-Vivo Localization and Tracking.
Sharma, Saransh.

Low-Power and Miniaturized Medical Electronics for In-Vivo Localization and Tracking. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 231 p.

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

Thesis (Ph.D.)--California Institute of Technology, 2023.

This item must not be sold to any third party vendors.

Medical electronic devices are an integral part of the healthcare system today. Significant advances have been made over the past few decades to yield highly miniaturized and low-power medical devices that are suitable for implantable, ingestible, or wearable applications. A key feature of medical devices that is central to their use in many applications is the capability to locate them precisely inside the body, and quite a lot of research effort has been expended in this direction. Location sensing is crucial for several applications: tracking pills in the GI tract, navigation during precision surgeries, endovascular procedures, robotic and minimally invasive surgery, and targeted therapy. The current gold-standard solutions for these procedures include invasive techniques such as endoscopy, or procedures that require repeated use of potentially harmful X-ray radiation such as CT scans. These techniques also require repeated evaluation in a hospital setting and are not conducive for non-clinical environments. While there are several alternative non-ionizing methods for imaging and localization based on electromagnetic tracking, radio-frequency, ultrasound, and optical tracking, none of them are able to simultaneously achieve a high field-of-view of tracking, high spatiotemporal resolution, fully wireless operation and miniaturization of the sensing devices, and system scalability with the number of devices. In this dissertation, we present a radiation-free system for high-precision localization and tracking of miniaturized wireless devices in vivo, using harmless magnetic field gradients.First, we demonstrate our system for precision surgery applications. We designed highly miniaturized, wireless and battery-less microdevices, capable of measuring and transmitting their local magnetic field. One such device can be attached to an implant inside the body and another to a surgical tool, such that both can simultaneously measure and communicate the magnetic field at their respective locations to an external receiver. The relative location of the two devices on a real-time display can enable precise surgical navigation without using X-ray fluoroscopy. The prototype device consists of a micro-chip fabricated in 65nm CMOS technology, a 3D magnetic sensor and an inductor-coil. The chip performs wireless power management, wireless bi-directional data-telemetry, and I2C communication with the sensor. Planar electromagnetic coils are designed for creating monotonically varying magnetic fields in the X, Y, and Z directions, resulting in field gradients that encode each spatial point with a unique magnetic field value. The concept of gradient-based spatial encoding is inspired by MRI. The system is tested in vitroto demonstrate a localization accuracy of <100µm in 3D, the highest reported to the best of our knowledge.Second, we demonstrate our system for localization and tracking of ingestible microdevices in the GI tract, which is valuable for the diagnosis and treatment of GI disorders. We designed highly miniaturized, low-power, and wireless ingestible devices to sense and transmit their local magnetic field as they travel through the GI tract. These devices consist of a 3D magnetic sensor, a Bluetooth microprocessor and a 2.4GHz Bluetooth antenna for wireless communication, all packaged into a 000- size capsule. The magnetic field sensed by the devices is created by using high-efficiency planar electromagnetic coils that encode each spatial point with a distinct magnetic field magnitude, allowing us to track the location of the devices unambiguously.

ISBN: 9798380267595Subjects--Topical Terms:

3560264
Barium.

Low-Power and Miniaturized Medical Electronics for In-Vivo Localization and Tracking.
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520 $a Medical electronic devices are an integral part of the healthcare system today. Significant advances have been made over the past few decades to yield highly miniaturized and low-power medical devices that are suitable for implantable, ingestible, or wearable applications. A key feature of medical devices that is central to their use in many applications is the capability to locate them precisely inside the body, and quite a lot of research effort has been expended in this direction. Location sensing is crucial for several applications: tracking pills in the GI tract, navigation during precision surgeries, endovascular procedures, robotic and minimally invasive surgery, and targeted therapy. The current gold-standard solutions for these procedures include invasive techniques such as endoscopy, or procedures that require repeated use of potentially harmful X-ray radiation such as CT scans. These techniques also require repeated evaluation in a hospital setting and are not conducive for non-clinical environments. While there are several alternative non-ionizing methods for imaging and localization based on electromagnetic tracking, radio-frequency, ultrasound, and optical tracking, none of them are able to simultaneously achieve a high field-of-view of tracking, high spatiotemporal resolution, fully wireless operation and miniaturization of the sensing devices, and system scalability with the number of devices. In this dissertation, we present a radiation-free system for high-precision localization and tracking of miniaturized wireless devices in vivo, using harmless magnetic field gradients.First, we demonstrate our system for precision surgery applications. We designed highly miniaturized, wireless and battery-less microdevices, capable of measuring and transmitting their local magnetic field. One such device can be attached to an implant inside the body and another to a surgical tool, such that both can simultaneously measure and communicate the magnetic field at their respective locations to an external receiver. The relative location of the two devices on a real-time display can enable precise surgical navigation without using X-ray fluoroscopy. The prototype device consists of a micro-chip fabricated in 65nm CMOS technology, a 3D magnetic sensor and an inductor-coil. The chip performs wireless power management, wireless bi-directional data-telemetry, and I2C communication with the sensor. Planar electromagnetic coils are designed for creating monotonically varying magnetic fields in the X, Y, and Z directions, resulting in field gradients that encode each spatial point with a unique magnetic field value. The concept of gradient-based spatial encoding is inspired by MRI. The system is tested in vitroto demonstrate a localization accuracy of <100µm in 3D, the highest reported to the best of our knowledge.Second, we demonstrate our system for localization and tracking of ingestible microdevices in the GI tract, which is valuable for the diagnosis and treatment of GI disorders. We designed highly miniaturized, low-power, and wireless ingestible devices to sense and transmit their local magnetic field as they travel through the GI tract. These devices consist of a 3D magnetic sensor, a Bluetooth microprocessor and a 2.4GHz Bluetooth antenna for wireless communication, all packaged into a 000- size capsule. The magnetic field sensed by the devices is created by using high-efficiency planar electromagnetic coils that encode each spatial point with a distinct magnetic field magnitude, allowing us to track the location of the devices unambiguously.
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