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Effects of Tau and Amyloid Proteins ...

Wales, Ryan.

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Effects of Tau and Amyloid Proteins on Functional Network Connectivity in Older Adults Without Dementia.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of Tau and Amyloid Proteins on Functional Network Connectivity in Older Adults Without Dementia./
Author:	Wales, Ryan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	100 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
Contained By:	Dissertations Abstracts International85-03B.
Subject:	Neurosciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30636994
ISBN:	9798380376044

Effects of Tau and Amyloid Proteins on Functional Network Connectivity in Older Adults Without Dementia.
Wales, Ryan.

Effects of Tau and Amyloid Proteins on Functional Network Connectivity in Older Adults Without Dementia. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 100 p.

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

Thesis (Ph.D.)--State University of New York at Stony Brook, 2023.

This item must not be sold to any third party vendors.

Neurofibrillary tau tangles and amyloid-beta plaques are typically associated with Alzheimer's disease, yet they can also be found in the brains of cognitively normal older adults. Due to individual differences in the rates of tau and amyloid accumulation, as well as age-related changes in functional network connectivity, the specific effects of these pathological proteins on resting-state network connectivity have not been well characterized. Here we used functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) data from the Alzheimer's Disease Neuroimaging Initiative database to examine both cross-sectional (N = 297) and longitudinal (N = 74) effects of tau and amyloid accumulation on functional connectivity and cognitive functioning among individuals without dementia. Cross-sectional tau levels were strongly associated with worse cognition in all domains, and amyloid levels were moderately associated with worse memory and executive function composite measures. Tau was associated with decreased within-network in the DMN, limbic, somatomotor, temporal parietal, and perivisual networks, whereas amyloid was associated with greater between-network connectivity and greater within-network connectivity in the FPN, dorsal attention, limbic, salience/ventral attention, and somatomotor networks. Further, graph theory analysis showed that tau was related to lower global and local efficiency, while amyloid was associated with lower global but higher local efficiency. In a longitudinal subsample, greater tau and amyloid accumulation were both associated with cognitive decline over time (mean time between visits: 2.1 years). Notably, greater tau accumulation was specifically related to memory and language decline, whereas greater amyloid accumulation was related to executive function decline. Longitudinal graph theory results were similar to cross-sectional results, showing tau-related decreases in local efficiency and amyloid-related increases in local efficiency. In sum, this study shows that amyloid and tau are both detrimental to cognition, yet both proteins seem to have opposite effects on functional connectivity, with or without controlling for the other protein. Tau was related to hypo-connectivity, and amyloid was related to hyper-connectivity in individuals without dementia. 

ISBN: 9798380376044Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Aging

Effects of Tau and Amyloid Proteins on Functional Network Connectivity in Older Adults Without Dementia.
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520 $a Neurofibrillary tau tangles and amyloid-beta plaques are typically associated with Alzheimer's disease, yet they can also be found in the brains of cognitively normal older adults. Due to individual differences in the rates of tau and amyloid accumulation, as well as age-related changes in functional network connectivity, the specific effects of these pathological proteins on resting-state network connectivity have not been well characterized. Here we used functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) data from the Alzheimer's Disease Neuroimaging Initiative database to examine both cross-sectional (N = 297) and longitudinal (N = 74) effects of tau and amyloid accumulation on functional connectivity and cognitive functioning among individuals without dementia. Cross-sectional tau levels were strongly associated with worse cognition in all domains, and amyloid levels were moderately associated with worse memory and executive function composite measures. Tau was associated with decreased within-network in the DMN, limbic, somatomotor, temporal parietal, and perivisual networks, whereas amyloid was associated with greater between-network connectivity and greater within-network connectivity in the FPN, dorsal attention, limbic, salience/ventral attention, and somatomotor networks. Further, graph theory analysis showed that tau was related to lower global and local efficiency, while amyloid was associated with lower global but higher local efficiency. In a longitudinal subsample, greater tau and amyloid accumulation were both associated with cognitive decline over time (mean time between visits: 2.1 years). Notably, greater tau accumulation was specifically related to memory and language decline, whereas greater amyloid accumulation was related to executive function decline. Longitudinal graph theory results were similar to cross-sectional results, showing tau-related decreases in local efficiency and amyloid-related increases in local efficiency. In sum, this study shows that amyloid and tau are both detrimental to cognition, yet both proteins seem to have opposite effects on functional connectivity, with or without controlling for the other protein. Tau was related to hypo-connectivity, and amyloid was related to hyper-connectivity in individuals without dementia. 
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