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Inhibiting Thioredoxin Reductase for...

Balgobin, Jessica Dristi.

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Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy./
Author:	Balgobin, Jessica Dristi.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	77 p.
Notes:	Source: Masters Abstracts International, Volume: 85-01.
Contained By:	Masters Abstracts International85-01.
Subject:	Organic chemistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30247723
ISBN:	9798379765569

Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy.
Balgobin, Jessica Dristi.

Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 77 p.

Source: Masters Abstracts International, Volume: 85-01.

Thesis (M.Sc.)--University of Toronto (Canada), 2023.

This item must not be sold to any third party vendors.

Conventional cancer treatment is limited by lack of selectivity, limited efficacy towards metastatic cancer and resistive mechanisms acquired by cancer cells. Thus, alternative cancer treatments such as molecular targeted therapy and photodynamic therapy have emerged as promising therapies to combat these issues, although these therapies also present their own limitations. Alternatively, these two types of therapies can be combined for enhanced potency, selectivity and to combat limitations presented by each type of therapy individually. This thesis describes a novel dual therapeutic approach whereby a single small molecule drug, DG-EryB, can irreversibly and covalently inhibit thioredoxin reductase 1 (TrxR1) for molecular targeted therapy, while simultaneously acting as a photosensitizer for photodynamic therapy. This thesis also describes how a photocleavable group can be attached to DG-EryB in a prodrug design for improved pharmacokinetic properties.

ISBN: 9798379765569Subjects--Topical Terms:

523952
Organic chemistry.
Subjects--Index Terms:

Inhibition

Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy.
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100 1 $a Balgobin, Jessica Dristi. $3 3763071
245 1 0 $a Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 77 p.
500 $a Source: Masters Abstracts International, Volume: 85-01.
500 $a Advisor: Beharry, Andrew;Nitz, Mark.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2023.
506 $a This item must not be sold to any third party vendors.
520 $a Conventional cancer treatment is limited by lack of selectivity, limited efficacy towards metastatic cancer and resistive mechanisms acquired by cancer cells. Thus, alternative cancer treatments such as molecular targeted therapy and photodynamic therapy have emerged as promising therapies to combat these issues, although these therapies also present their own limitations. Alternatively, these two types of therapies can be combined for enhanced potency, selectivity and to combat limitations presented by each type of therapy individually. This thesis describes a novel dual therapeutic approach whereby a single small molecule drug, DG-EryB, can irreversibly and covalently inhibit thioredoxin reductase 1 (TrxR1) for molecular targeted therapy, while simultaneously acting as a photosensitizer for photodynamic therapy. This thesis also describes how a photocleavable group can be attached to DG-EryB in a prodrug design for improved pharmacokinetic properties.
590 $a School code: 0779.
650 4 $a Organic chemistry. $3 523952
650 4 $a Biochemistry. $3 518028
650 4 $a Oncology. $3 751006
653 $a Inhibition
653 $a Photocage
653 $a Photodynamic therapy
653 $a Photosensitizer
653 $a Targeted therapy
653 $a Thioredoxin reductase
653 $a Cancer treatment
653 $a DG-EryB
690 $a 0490
690 $a 0487
690 $a 0992
710 2 $a University of Toronto (Canada). $b Chemistry. $3 3178441
773 0 $t Masters Abstracts International $g 85-01.
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791 $a M.Sc.
792 $a 2023
793 $a English
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