東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Antibiotics and their mechanisms of ...

Nagarajan, Deepesh.

FindBook

Google Book

Amazon

博客來

Antibiotics and their mechanisms of action

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Antibiotics and their mechanisms of action/ edited by Deepesh Nagarajan.
其他作者:	Nagarajan, Deepesh.
出版者:	Singapore :Springer Nature Singapore : : 2024.,
面頁冊數:	xiii, 177 p. :ill. (chiefly color), digital ;24 cm.
內容註:	Chapter 1. The history of antibiotics -- Chapter 2. Methods for antibiotic discovery -- Chapter 3. Penicillin -- Chapter 4. Vancomycin -- Chapter 5. Antimicrobial peptides -- Chapter 6. Quinolones -- Chapter 7. Rifampicin -- Chapter 8. Tetracyclines -- Chapter 9. Streptomycin -- Chapter 10. Chloramphenicol -- Chapter 11. Antimetabolites -- Chapter 12. Mycolic acid inhibitors -- Chapter 13. Other antimicrobial agents -- Chapter 14. Antibiotic Pharmacology and Biopharmaceutics.
Contained By:	Springer Nature eBook
標題:	Antibiotics. -
電子資源:	https://doi.org/10.1007/978-981-97-6851-6
ISBN:	9789819768516

Antibiotics and their mechanisms of action
Antibiotics and their mechanisms of action[electronic resource] /edited by Deepesh Nagarajan. - Singapore :Springer Nature Singapore :2024. - xiii, 177 p. :ill. (chiefly color), digital ;24 cm.

Chapter 1. The history of antibiotics -- Chapter 2. Methods for antibiotic discovery -- Chapter 3. Penicillin -- Chapter 4. Vancomycin -- Chapter 5. Antimicrobial peptides -- Chapter 6. Quinolones -- Chapter 7. Rifampicin -- Chapter 8. Tetracyclines -- Chapter 9. Streptomycin -- Chapter 10. Chloramphenicol -- Chapter 11. Antimetabolites -- Chapter 12. Mycolic acid inhibitors -- Chapter 13. Other antimicrobial agents -- Chapter 14. Antibiotic Pharmacology and Biopharmaceutics.

"Antibiotics and their mechanisms of action" provides a deep and lucid understanding of the mechanisms of action of various antibiotics. The experiments followed to decipher the mechanisms have been explained in great depth, which is a novelty in this textbook. Most undergraduate textbooks on antibiotics place emphasis on their use from the clinician's perspective. Taking penicillin as an example, typical textbooks discuss its discovery, penicillin's β-lactam derivatives, routes of administration, the diseases and pathogens treated with β-lactam antibiotics, side effects, and finally the mechanisms of resistance that have evolved against penicillin. No description of how its mechanism of action was deciphered is ever provided. This textbook describes how simple experiments using protoplasts, covalent affinity chromatography, SYPRO Orange binding assays, and X-ray crystallography have all been used to elucidate the mechanism of action of penicillin. Like this, the complicated mechanisms of action of different antibiotics have been presented in simple terms with the help of original illustrations. Chapters 8-10 cover the mechanisms of action of anti-ribosomal antibiotics (tetracycline, streptomycin, chloramphenicol). Elucidating the mechanisms of action for these antibiotics requires complex experiments such as ex vivo transcription via a cell-free ribosomal reaction mixture, photolabelling experiments, and sucrose density gradient centrifugation of radiolabelled translation reactants and products. These experiments are conveyed to the reader in the simplest possible language and with easily understandable, appealing illustrations. Finally, the reader is challenged at the end of every chapter with original questions, testing whether hecan apply the concepts he learned in the preceding chapter to research-level problems. This book is written primarily for undergraduate students in microbiology or biotechnology courses to help them develop a simplistic yet comprehensive understanding of the mechanisms underlying antibiotics action. It is believed that this book will prepare the students for PhD level research.

ISBN: 9789819768516

Standard No.: 10.1007/978-981-97-6851-6doiSubjects--Topical Terms:

670318
Antibiotics.

LC Class. No.: RM267

Dewey Class. No.: 615.329

Antibiotics and their mechanisms of action
LDR:03616nmm a2200325 a 4500 001 2388766
003 DE-He213
005 20241230115303.0
006 m d
007 cr nn 008maaau
008 250916s2024 si s 0 eng d
020 $a 9789819768516 $q (electronic bk.)
020 $a 9789819768509 $q (paper)
024 7 $a 10.1007/978-981-97-6851-6 $2 doi
035 $a 978-981-97-6851-6
040 $a GP $c GP
041 0 $a eng
050 4 $a RM267
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
072 7 $a MKG $2 thema
082 0 4 $a 615.329 $2 23
090 $a RM267 $b .A629 2024
245 0 0 $a Antibiotics and their mechanisms of action $h [electronic resource] / $c edited by Deepesh Nagarajan.
260 $a Singapore : $b Springer Nature Singapore : $b Imprint: Springer, $c 2024.
300 $a xiii, 177 p. : $b ill. (chiefly color), digital ; $c 24 cm.
505 0 $a Chapter 1. The history of antibiotics -- Chapter 2. Methods for antibiotic discovery -- Chapter 3. Penicillin -- Chapter 4. Vancomycin -- Chapter 5. Antimicrobial peptides -- Chapter 6. Quinolones -- Chapter 7. Rifampicin -- Chapter 8. Tetracyclines -- Chapter 9. Streptomycin -- Chapter 10. Chloramphenicol -- Chapter 11. Antimetabolites -- Chapter 12. Mycolic acid inhibitors -- Chapter 13. Other antimicrobial agents -- Chapter 14. Antibiotic Pharmacology and Biopharmaceutics.
520 $a "Antibiotics and their mechanisms of action" provides a deep and lucid understanding of the mechanisms of action of various antibiotics. The experiments followed to decipher the mechanisms have been explained in great depth, which is a novelty in this textbook. Most undergraduate textbooks on antibiotics place emphasis on their use from the clinician's perspective. Taking penicillin as an example, typical textbooks discuss its discovery, penicillin's β-lactam derivatives, routes of administration, the diseases and pathogens treated with β-lactam antibiotics, side effects, and finally the mechanisms of resistance that have evolved against penicillin. No description of how its mechanism of action was deciphered is ever provided. This textbook describes how simple experiments using protoplasts, covalent affinity chromatography, SYPRO Orange binding assays, and X-ray crystallography have all been used to elucidate the mechanism of action of penicillin. Like this, the complicated mechanisms of action of different antibiotics have been presented in simple terms with the help of original illustrations. Chapters 8-10 cover the mechanisms of action of anti-ribosomal antibiotics (tetracycline, streptomycin, chloramphenicol). Elucidating the mechanisms of action for these antibiotics requires complex experiments such as ex vivo transcription via a cell-free ribosomal reaction mixture, photolabelling experiments, and sucrose density gradient centrifugation of radiolabelled translation reactants and products. These experiments are conveyed to the reader in the simplest possible language and with easily understandable, appealing illustrations. Finally, the reader is challenged at the end of every chapter with original questions, testing whether hecan apply the concepts he learned in the preceding chapter to research-level problems. This book is written primarily for undergraduate students in microbiology or biotechnology courses to help them develop a simplistic yet comprehensive understanding of the mechanisms underlying antibiotics action. It is believed that this book will prepare the students for PhD level research.
650 0 $a Antibiotics. $3 670318
650 1 4 $a Pharmacology. $3 634543
650 2 4 $a Medical Microbiology. $3 890951
650 2 4 $a Drug Delivery. $3 3531319
700 1 $a Nagarajan, Deepesh. $3 3754053
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-981-97-6851-6
950 $a Biomedical and Life Sciences (SpringerNature-11642)