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The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations./
Author:	Peralta-Neel, Zulema M.
Description:	1 online resource (504 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29394942click for full text (PQDT)
ISBN:	9798379776244

The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations.
Peralta-Neel, Zulema M.

The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations. - 1 online resource (504 pages)

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--New York University, 2023.

Includes bibliographical references

Endoperoxide motifs can be found in a plethora of natural products and have demonstrated toxicity to a number of cancer cell lines. The synthesis of these endoperoxides usually requires the formation of a hydroperoxide or a silylperoxide. The hydroperoxide is then deprotonated using a base, and an intramolecular Michael addition leads to formation of the cyclic core. Chapter One of this thesis will discuss our attempts at finding a new catalyst that could lead to hydroperoxidations in high yields. The catalyst we discovered, Co(pic)2, has demonstrated different reactivity than the cobalt 1,3-diketonate complexes that are used to form silylperoxides. Chapter Two presents two new ways to form 1,2-dioxolanes or 1,2-dioxanes by suggesting the formation of a substrate that could inhibit the major path of decomposition seen in base-promoted oxa-Michael additions, and proposes using a Semmelhack-like reaction to form endoperoxide cores in one step. Chapter Three expands on cobalt picolinate complexes and how they can be used to oxidize alkynes into 1,2-diketones or methyl ketones depending on the substrate used. Chapter Four describes our continued work on base-promoted cyclizations to form endoperoxides, this time with a focus on the formation of aromatic peroxides, which have been notoriously difficult to isolate in a laboratory setting.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379776244Subjects--Topical Terms:

523952
Organic chemistry.
Subjects--Index Terms:

Cobalt picolinateIndex Terms--Genre/Form:

542853
Electronic books.

The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations.
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502 $a Thesis (Ph.D.)--New York University, 2023.
504 $a Includes bibliographical references
520 $a Endoperoxide motifs can be found in a plethora of natural products and have demonstrated toxicity to a number of cancer cell lines. The synthesis of these endoperoxides usually requires the formation of a hydroperoxide or a silylperoxide. The hydroperoxide is then deprotonated using a base, and an intramolecular Michael addition leads to formation of the cyclic core. Chapter One of this thesis will discuss our attempts at finding a new catalyst that could lead to hydroperoxidations in high yields. The catalyst we discovered, Co(pic)2, has demonstrated different reactivity than the cobalt 1,3-diketonate complexes that are used to form silylperoxides. Chapter Two presents two new ways to form 1,2-dioxolanes or 1,2-dioxanes by suggesting the formation of a substrate that could inhibit the major path of decomposition seen in base-promoted oxa-Michael additions, and proposes using a Semmelhack-like reaction to form endoperoxide cores in one step. Chapter Three expands on cobalt picolinate complexes and how they can be used to oxidize alkynes into 1,2-diketones or methyl ketones depending on the substrate used. Chapter Four describes our continued work on base-promoted cyclizations to form endoperoxides, this time with a focus on the formation of aromatic peroxides, which have been notoriously difficult to isolate in a laboratory setting.
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538 $a Mode of access: World Wide Web
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653 $a Hydroperoxides
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