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Uncovering Key Determinants of Skeletal Muscle Repair.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Uncovering Key Determinants of Skeletal Muscle Repair./
Author:	Horwitz, Naftali.
Description:	1 online resource (110 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
Contained By:	Dissertations Abstracts International84-12B.
Subject:	Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30425830click for full text (PQDT)
ISBN:	9798379615833

Uncovering Key Determinants of Skeletal Muscle Repair.
Horwitz, Naftali.

Uncovering Key Determinants of Skeletal Muscle Repair. - 1 online resource (110 pages)

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

Thesis (Ph.D.)--Harvard University, 2023.

Includes bibliographical references

Skeletal muscle regeneration is a complex process that allows damaged muscle tissue to be repaired and restored to its original function. This process involves a series of coordinated events, including inflammation, satellite cell activation and proliferation, myoblast differentiation and fusion, and muscle fiber maturation. The success of muscle regeneration relies on the ability of satellite cells to differentiate into functional myoblasts, which can fuse with existing fibers or form new fibers to replace damaged or lost muscle tissue. Various factors, such as age, disease, and injury, can impair muscle regeneration, leading to muscle wasting and weakness. Understanding the cellular and molecular mechanisms underlying skeletal muscle regeneration is crucial for developing effective therapeutic strategies to enhance muscle repair and function in various pathologies.In this thesis I sought to understand this regenerative process further by interrogating the earliest cell autonomous mechanisms that transition a muscle stem cell from quiescence to activation. Specifically, I describe Fos, a member of the AP-I family of transcription factors and a classical oncogene, as an early regulator of satellite cell activity which initiates key stem cell functions, including cell cycle entry, proliferative expansion, and muscle regeneration, via induction of ''pro-regenerative'' target genes that stimulate cell migration, division, and differentiation.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379615833Subjects--Topical Terms:

518028
Biochemistry.
Subjects--Index Terms:

Skeletal muscle regenerationIndex Terms--Genre/Form:

542853
Electronic books.

Uncovering Key Determinants of Skeletal Muscle Repair.
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245 1 0 $a Uncovering Key Determinants of Skeletal Muscle Repair.
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300 $a 1 online resource (110 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
500 $a Advisor: Wagers, Amy.
502 $a Thesis (Ph.D.)--Harvard University, 2023.
504 $a Includes bibliographical references
520 $a Skeletal muscle regeneration is a complex process that allows damaged muscle tissue to be repaired and restored to its original function. This process involves a series of coordinated events, including inflammation, satellite cell activation and proliferation, myoblast differentiation and fusion, and muscle fiber maturation. The success of muscle regeneration relies on the ability of satellite cells to differentiate into functional myoblasts, which can fuse with existing fibers or form new fibers to replace damaged or lost muscle tissue. Various factors, such as age, disease, and injury, can impair muscle regeneration, leading to muscle wasting and weakness. Understanding the cellular and molecular mechanisms underlying skeletal muscle regeneration is crucial for developing effective therapeutic strategies to enhance muscle repair and function in various pathologies.In this thesis I sought to understand this regenerative process further by interrogating the earliest cell autonomous mechanisms that transition a muscle stem cell from quiescence to activation. Specifically, I describe Fos, a member of the AP-I family of transcription factors and a classical oncogene, as an early regulator of satellite cell activity which initiates key stem cell functions, including cell cycle entry, proliferative expansion, and muscle regeneration, via induction of ''pro-regenerative'' target genes that stimulate cell migration, division, and differentiation.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Biochemistry. $3 518028
650 4 $a Cellular biology. $3 3172791
650 4 $a Molecular biology. $3 517296
653 $a Skeletal muscle regeneration
653 $a Muscle tissue
653 $a Satellite cell activation
653 $a Muscle regeneration
653 $a Stem cell
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710 2 $a Harvard University. $b Chemical Biology. $3 3172793
773 0 $t Dissertations Abstracts International $g 84-12B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30425830 $z click for full text (PQDT)