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Characterisation of Cervicovaginal Fluid (CVF) Biomarkers Across Gestation for the Identification of Spontaneous Preterm Birth (sPTB).

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterisation of Cervicovaginal Fluid (CVF) Biomarkers Across Gestation for the Identification of Spontaneous Preterm Birth (sPTB)./
Author:	Appiah, Kubi.
Description:	1 online resource (330 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-05, Section: B.
Contained By:	Dissertations Abstracts International83-05B.
Subject:	Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28851369click for full text (PQDT)
ISBN:	9798492728724

Characterisation of Cervicovaginal Fluid (CVF) Biomarkers Across Gestation for the Identification of Spontaneous Preterm Birth (sPTB).
Appiah, Kubi.

Characterisation of Cervicovaginal Fluid (CVF) Biomarkers Across Gestation for the Identification of Spontaneous Preterm Birth (sPTB). - 1 online resource (330 pages)

Source: Dissertations Abstracts International, Volume: 83-05, Section: B.

Thesis (Ph.D.)--The Chinese University of Hong Kong (Hong Kong), 2021.

Includes bibliographical references

BackgroundSpontaneous preterm birth (sPTB) is defined as birth occurring < 37 weeks' gestation; this obstetric problem accounts for 11% of deliveries worldwide. Though efforts are being made to decrease the occurrence of sPTB, it is still a major cause perinatal morbidity and mortality. A myriad of obstetrics strategies to screen for sPTB, such as the measurement of cervical length, fetal fibronectin and phosphorylated insulin-like growth factor binding protein-1 have emerged. However, due to the heterogeneity of sPTB, there is unlikely to be a single test that will be able to predict this pregnancy complication, but a combination of tests may improve the clinical predictive performance. Therefore, our objectives in this study were to 1) evaluate the screening performance of the CVF biomarkers panel developed by Carmentix for the prediction of sPTB at 16-24 weeks' gestation in an unselected Hong Kong Chinese population. 2) establish multi-marker prediction models (maternal characteristics, CVF biomarkers, cervical length) to increase predictive performance for spontaneous PTB and 3) characterise the temporal changes of the CVF biomarkers and cervical length across gestation in women complicated by sPTB and to compare the differences between those with sPTB and term births.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798492728724Subjects--Topical Terms:

518431
Physiology.
Subjects--Index Terms:

Cervicovaginal fluidIndex Terms--Genre/Form:

542853
Electronic books.

Characterisation of Cervicovaginal Fluid (CVF) Biomarkers Across Gestation for the Identification of Spontaneous Preterm Birth (sPTB).
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245 1 0 $a Characterisation of Cervicovaginal Fluid (CVF) Biomarkers Across Gestation for the Identification of Spontaneous Preterm Birth (sPTB).
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500 $a Source: Dissertations Abstracts International, Volume: 83-05, Section: B.
500 $a Advisor: Poon, Liona.
502 $a Thesis (Ph.D.)--The Chinese University of Hong Kong (Hong Kong), 2021.
504 $a Includes bibliographical references
520 $a BackgroundSpontaneous preterm birth (sPTB) is defined as birth occurring < 37 weeks' gestation; this obstetric problem accounts for 11% of deliveries worldwide. Though efforts are being made to decrease the occurrence of sPTB, it is still a major cause perinatal morbidity and mortality. A myriad of obstetrics strategies to screen for sPTB, such as the measurement of cervical length, fetal fibronectin and phosphorylated insulin-like growth factor binding protein-1 have emerged. However, due to the heterogeneity of sPTB, there is unlikely to be a single test that will be able to predict this pregnancy complication, but a combination of tests may improve the clinical predictive performance. Therefore, our objectives in this study were to 1) evaluate the screening performance of the CVF biomarkers panel developed by Carmentix for the prediction of sPTB at 16-24 weeks' gestation in an unselected Hong Kong Chinese population. 2) establish multi-marker prediction models (maternal characteristics, CVF biomarkers, cervical length) to increase predictive performance for spontaneous PTB and 3) characterise the temporal changes of the CVF biomarkers and cervical length across gestation in women complicated by sPTB and to compare the differences between those with sPTB and term births.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Physiology. $3 518431
650 4 $a Biochemistry. $3 518028
650 4 $a Developmental biology. $3 592588
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653 $a Cervicovaginal fluid
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653 $a Spontaneous preterm birth
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773 0 $t Dissertations Abstracts International $g 83-05B.
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