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Epidemiology, Natural History, and Cancer Prevention of Non-Alcoholic Fatty Liver Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Epidemiology, Natural History, and Cancer Prevention of Non-Alcoholic Fatty Liver Disease./
Author:	Zou, Biyao.
Description:	1 online resource (231 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
Contained By:	Dissertations Abstracts International84-04B.
Subject:	Databases. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29342279click for full text (PQDT)
ISBN:	9798351499901

Epidemiology, Natural History, and Cancer Prevention of Non-Alcoholic Fatty Liver Disease.
Zou, Biyao.

Epidemiology, Natural History, and Cancer Prevention of Non-Alcoholic Fatty Liver Disease. - 1 online resource (231 pages)

Source: Dissertations Abstracts International, Volume: 84-04, Section: B.

Thesis (Ph.D.)--Stanford University, 2022.

Includes bibliographical references

Non-alcoholic fatty liver disease (NAFLD) is defined by the presence of excessive hepatic steatosis (> 5%) in the absence of other identifiable causes, including excessive alcohol use and viral hepatitis. It is a major cause of chronic liver disease globally with a prevalence of 29.8% and 35.7% for the United States. NAFLD also carries a substantial health, economic, and patient reported outcome burden. The overall goal of this dissertation is to use different statistical and epidemiological methods to study the epidemiology, natural history, and cancer prevention of NAFLD. In the first part of the dissertation, we applied the meta-analysis method to estimate the prevalence, incidence, clinical characteristics, and outcome of NAFLD in the Asian population. The evidence can assist stakeholders in understanding disease burden of NAFLD in Asia. In the second part, we investigated the prevalence and outcome data for non-obese NAFLD for the multiethnic US population and discovered that non-obese individuals with NAFLD had significantly higher all-cause mortality than obese individuals with NAFLD. Finally, we applied the causal inference method to determine the association between statin initiation and the risk of live cancer among patients with NAFLD. These chapters demonstrated NAFLD is truly becoming a global disease burden and future studies should be devoted to investigating the prevention and treatment of NAFLD.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798351499901Subjects--Topical Terms:

747532
Databases.
Index Terms--Genre/Form:

542853
Electronic books.

Epidemiology, Natural History, and Cancer Prevention of Non-Alcoholic Fatty Liver Disease.
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100 1 $a Zou, Biyao. $3 3700433
245 1 0 $a Epidemiology, Natural History, and Cancer Prevention of Non-Alcoholic Fatty Liver Disease.
264 0 $c 2022
300 $a 1 online resource (231 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
500 $a Advisor: Odden, Michelle; Sainani, Kristin; Wang, Shan Xiang; Nguyen, Mindie.
502 $a Thesis (Ph.D.)--Stanford University, 2022.
504 $a Includes bibliographical references
520 $a Non-alcoholic fatty liver disease (NAFLD) is defined by the presence of excessive hepatic steatosis (> 5%) in the absence of other identifiable causes, including excessive alcohol use and viral hepatitis. It is a major cause of chronic liver disease globally with a prevalence of 29.8% and 35.7% for the United States. NAFLD also carries a substantial health, economic, and patient reported outcome burden. The overall goal of this dissertation is to use different statistical and epidemiological methods to study the epidemiology, natural history, and cancer prevention of NAFLD. In the first part of the dissertation, we applied the meta-analysis method to estimate the prevalence, incidence, clinical characteristics, and outcome of NAFLD in the Asian population. The evidence can assist stakeholders in understanding disease burden of NAFLD in Asia. In the second part, we investigated the prevalence and outcome data for non-obese NAFLD for the multiethnic US population and discovered that non-obese individuals with NAFLD had significantly higher all-cause mortality than obese individuals with NAFLD. Finally, we applied the causal inference method to determine the association between statin initiation and the risk of live cancer among patients with NAFLD. These chapters demonstrated NAFLD is truly becoming a global disease burden and future studies should be devoted to investigating the prevention and treatment of NAFLD.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Databases. $3 747532
650 4 $a Liver cancer. $3 3560852
650 4 $a Epidemiology. $3 568544
650 4 $a Mortality. $3 533218
650 4 $a Magnetic resonance imaging. $3 554355
650 4 $a Obesity. $3 525736
650 4 $a Medical imaging. $3 3172799
650 4 $a Medicine. $3 641104
650 4 $a Public health. $3 534748
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0766
690 $a 0574
690 $a 0564
690 $a 0573
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Stanford University. $3 754827
773 0 $t Dissertations Abstracts International $g 84-04B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29342279 $z click for full text (PQDT)