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Tuning Luminescence from Carbon Nanodots : = A New Strategy for Antimicrobial Inactivation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Tuning Luminescence from Carbon Nanodots :/
Reminder of title:	A New Strategy for Antimicrobial Inactivation.
Author:	Knoblauch, Rachael M.
Description:	1 online resource (490 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
Contained By:	Dissertations Abstracts International83-03B.
Subject:	Physical chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28650900click for full text (PQDT)
ISBN:	9798538112647

Tuning Luminescence from Carbon Nanodots : = A New Strategy for Antimicrobial Inactivation.
Knoblauch, Rachael M.

Tuning Luminescence from Carbon Nanodots :A New Strategy for Antimicrobial Inactivation. - 1 online resource (490 pages)

Source: Dissertations Abstracts International, Volume: 83-03, Section: B.

Thesis (Ph.D.)--University of Maryland, Baltimore County, 2021.

Includes bibliographical references

Beyond antibiotics, sterilization techniques hold significant promise in combating the growing threat of bacterial antibiotic resistance-which has retained urgency in recent years. One such strategy is antimicrobial photodynamic inactivation (APDI) of bacteria, also known as antimicrobial photodynamic therapy. APDI-which combines excitation light, molecular oxygen, and a photosensitizing agent to generate highly reactive oxygen species (ROS)-is broadly effective against many pathogens. Activity is controllable by modulating exposure light and tunable by photosensitizer properties. Although many photosensitizers are reported, many are small molecules limited in scalability by complex synthetic procedures, purification requirements, and costly reagents. Carbon nanodots present a promising alternative. These fluorescent nanoparticles are composed of many-layered oxidized graphene and are known combustion byproducts that may be easily and inexpensively collected. To date, most carbon dot research has focused on tuning fluorescent properties. In this emerging chapter of carbon nanodot research, we aim instead to tune the carbon dot properties for APDI. We report a simple set-up, employing the combustion of natural gas for nanodot collection together with an array of diverse precursors to gain novel photophysical properties. Namely, we report the collection of phosphorescent brominated carbon nanodots, and further characterize their ROS-generating capabilities (producing both singlet oxygen and hydroxyl radical) with 365 nm activation. Remarkably, we find them to be effective APDI photosensitizers against both gram-negative Escherichia coli and gram-positive Staphylococcus aureus and Listeria monocytogenes. Further, we find that these properties are all enhanced by the principles of "inter" metal-enhanced fluorescence, employing the "Quanta Plate™" plasmonic silver platform. We conclude by suggesting further tuning of the synthetic regime to reach new applications in the titular objective: "Tuning Luminescence from Carbon Nanodots.".

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798538112647Subjects--Topical Terms:

1981412
Physical chemistry.
Subjects--Index Terms:

AntimicrobialIndex Terms--Genre/Form:

542853
Electronic books.

Tuning Luminescence from Carbon Nanodots : = A New Strategy for Antimicrobial Inactivation.
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504 $a Includes bibliographical references
520 $a Beyond antibiotics, sterilization techniques hold significant promise in combating the growing threat of bacterial antibiotic resistance-which has retained urgency in recent years. One such strategy is antimicrobial photodynamic inactivation (APDI) of bacteria, also known as antimicrobial photodynamic therapy. APDI-which combines excitation light, molecular oxygen, and a photosensitizing agent to generate highly reactive oxygen species (ROS)-is broadly effective against many pathogens. Activity is controllable by modulating exposure light and tunable by photosensitizer properties. Although many photosensitizers are reported, many are small molecules limited in scalability by complex synthetic procedures, purification requirements, and costly reagents. Carbon nanodots present a promising alternative. These fluorescent nanoparticles are composed of many-layered oxidized graphene and are known combustion byproducts that may be easily and inexpensively collected. To date, most carbon dot research has focused on tuning fluorescent properties. In this emerging chapter of carbon nanodot research, we aim instead to tune the carbon dot properties for APDI. We report a simple set-up, employing the combustion of natural gas for nanodot collection together with an array of diverse precursors to gain novel photophysical properties. Namely, we report the collection of phosphorescent brominated carbon nanodots, and further characterize their ROS-generating capabilities (producing both singlet oxygen and hydroxyl radical) with 365 nm activation. Remarkably, we find them to be effective APDI photosensitizers against both gram-negative Escherichia coli and gram-positive Staphylococcus aureus and Listeria monocytogenes. Further, we find that these properties are all enhanced by the principles of "inter" metal-enhanced fluorescence, employing the "Quanta Plate™" plasmonic silver platform. We conclude by suggesting further tuning of the synthetic regime to reach new applications in the titular objective: "Tuning Luminescence from Carbon Nanodots.".
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650 4 $a Light. $3 524021
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