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Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines./
Author:	Kukk, Kora.
Description:	1 online resource (131 pages)
Notes:	Source: Masters Abstracts International, Volume: 84-06.
Contained By:	Masters Abstracts International84-06.
Subject:	Biocompatibility. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30195056click for full text (PQDT)
ISBN:	9798358407688

Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines.
Kukk, Kora.

Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines. - 1 online resource (131 pages)

Source: Masters Abstracts International, Volume: 84-06.

Thesis (M.Sc.)--The University of Maine, 2022.

Includes bibliographical references

Aquaculture is a large part of the food production sector which is greatly expanding. One of the largest losses in aquaculture is due to pathogens. Current solutions for protecting farmed finfish from pathogens can be very expensive with variable efficiency. Current disease prevention strategies include vaccination. Types of vaccines include immersion vaccines, feed vaccines, and injectable vaccines. The most popular solution is oil-based injectable vaccines due to its protection. However, the oil-based adjuvant used in most of these formulations causes adverse reactions in the fish including reduced growth. These vaccines require multiple administrations throughout the fish's lifetime causing unwanted handling stress and additional labor costs. Preliminary trials show that cellulose nanomaterials cause minimal adverse reactions when injected into salmon and does not significantly affect their growth. The goal of this research was to create an adjuvant from cellulose nanomaterials which would increase bacterin efficacy while avoiding harmful side effects. A prolonged release formulation was also desirable, obviating the need for multiple vaccinations. Additionally, hydrogels have been used for a wide variety of applications including drug delivery, making them an attractive aquatic vaccine adjuvant. Cellulose nanomaterials were decided as the polymer to make up the hydrogel matrix due to their biocompatibility, sustainability, high tunability, high abundance, low cost. The development of the hydrogel formulation, modifying the hydrogel for easier delivery into the salmon, measuring the diffusive properties of the hydrogel, and in vivo testing of the hydrogel for analysis of delivery methods and reactions to the formulation are described in this research.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798358407688Subjects--Topical Terms:

656157
Biocompatibility.
Index Terms--Genre/Form:

542853
Electronic books.

Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines.
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100 1 $a Kukk, Kora. $3 3695365
245 1 0 $a Developing and Characterizing a Novel Tempo CNF Hydrogel Adjuvant and Delivery System for Aquatic Vaccines.
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500 $a Source: Masters Abstracts International, Volume: 84-06.
500 $a Advisor: Mason, Michael; Bouchard, Deborah; Tilbury, Karissa.
502 $a Thesis (M.Sc.)--The University of Maine, 2022.
504 $a Includes bibliographical references
520 $a Aquaculture is a large part of the food production sector which is greatly expanding. One of the largest losses in aquaculture is due to pathogens. Current solutions for protecting farmed finfish from pathogens can be very expensive with variable efficiency. Current disease prevention strategies include vaccination. Types of vaccines include immersion vaccines, feed vaccines, and injectable vaccines. The most popular solution is oil-based injectable vaccines due to its protection. However, the oil-based adjuvant used in most of these formulations causes adverse reactions in the fish including reduced growth. These vaccines require multiple administrations throughout the fish's lifetime causing unwanted handling stress and additional labor costs. Preliminary trials show that cellulose nanomaterials cause minimal adverse reactions when injected into salmon and does not significantly affect their growth. The goal of this research was to create an adjuvant from cellulose nanomaterials which would increase bacterin efficacy while avoiding harmful side effects. A prolonged release formulation was also desirable, obviating the need for multiple vaccinations. Additionally, hydrogels have been used for a wide variety of applications including drug delivery, making them an attractive aquatic vaccine adjuvant. Cellulose nanomaterials were decided as the polymer to make up the hydrogel matrix due to their biocompatibility, sustainability, high tunability, high abundance, low cost. The development of the hydrogel formulation, modifying the hydrogel for easier delivery into the salmon, measuring the diffusive properties of the hydrogel, and in vivo testing of the hydrogel for analysis of delivery methods and reactions to the formulation are described in this research.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Biocompatibility. $3 656157
650 4 $a Physiology. $3 518431
650 4 $a Aquaculture. $3 545878
650 4 $a Pathogens. $3 3540520
650 4 $a Vaccines. $3 684854
650 4 $a Bacteria. $3 550366
650 4 $a Chemistry. $3 516420
650 4 $a Nanomaterials. $3 3558221
650 4 $a Breakdowns. $3 3682712
650 4 $a Disease prevention. $3 3685279
650 4 $a Offshore. $3 3681420
650 4 $a Drug dosages. $3 3557732
650 4 $a Polymers. $3 535398
650 4 $a Cellulose. $3 588995
650 4 $a Fish hatcheries. $3 2003221
650 4 $a Antibiotics. $3 670318
650 4 $a Deoxyribonucleic acid--DNA. $3 3546879
650 4 $a Design. $3 518875
650 4 $a Antigens. $3 700737
650 4 $a Meat quality. $3 3695366
650 4 $a Salinity. $3 594109
650 4 $a Hydrogels. $3 1305894
650 4 $a Animal sciences. $3 3174829
650 4 $a Aquatic sciences. $3 3174300
650 4 $a Biology. $3 522710
650 4 $a Genetics. $3 530508
650 4 $a Nanotechnology. $3 526235
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Polymer chemistry. $3 3173488
655 7 $a Electronic books. $2 lcsh $3 542853
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690 $a 0719
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710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a The University of Maine. $3 1029373
773 0 $t Masters Abstracts International $g 84-06.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30195056 $z click for full text (PQDT)