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Epidemiology, Evolution, and Diagnostics of Tuberculosis in Humans and Animals.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Epidemiology, Evolution, and Diagnostics of Tuberculosis in Humans and Animals./
Author:	Hadi, Syeda Anum.
Description:	1 online resource (150 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-02, Section: B.
Contained By:	Dissertations Abstracts International84-02B.
Subject:	Epidemiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28963092click for full text (PQDT)
ISBN:	9798841761136

Epidemiology, Evolution, and Diagnostics of Tuberculosis in Humans and Animals.
Hadi, Syeda Anum.

Epidemiology, Evolution, and Diagnostics of Tuberculosis in Humans and Animals. - 1 online resource (150 pages)

Source: Dissertations Abstracts International, Volume: 84-02, Section: B.

Thesis (Ph.D.)--Michigan State University, 2022.

Includes bibliographical references

Tuberculosis control in animals and humans alike requires early detection of Mycobacterium tuberculosis complex as well as current knowledge about the transmission patterns of the disease in the respective populations. These two building blocks provide the foundation on which the disease control programs can build their policies to expediate control efforts. In this thesis we amalgamate molecular epidemiology, genomics, and proteomics. We studied the transmission pattern of M. tuberculosis and its evolution within a marginalized population. The patterns led to the identification of gaps in TB control policies in marginalized populations with little access to healthcare. Similarly, we studied the genomewide polymorphisms in a naturally attenuated strain - M. bovis strain Ravenel to elucidate possible mechanisms for its reduced virulence and pathogenicity. Insights gained from genome sequence analysis in conjunction with pathogenesis study for M. bovis Ravenel paved the pathway to defining the complex and multi-faceted reasons for attenuation of the oldest bacteria of the world. Next, pathogen-specific biomarkers were evaluated to assist in unambiguous disease detection across multiple host species. Discovery and validation of biomarkers work facilitated the field diagnostic applications for TB in animals and humans. This three-pronged approach developed in this study, understanding the genomic basis of attenuation, and enhanced field TB diagnostics in the animal-human interface.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798841761136Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

BovineIndex Terms--Genre/Form:

542853
Electronic books.

Epidemiology, Evolution, and Diagnostics of Tuberculosis in Humans and Animals.
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500 $a Source: Dissertations Abstracts International, Volume: 84-02, Section: B.
500 $a Advisor: Sreevatsan, Srinand.
502 $a Thesis (Ph.D.)--Michigan State University, 2022.
504 $a Includes bibliographical references
520 $a Tuberculosis control in animals and humans alike requires early detection of Mycobacterium tuberculosis complex as well as current knowledge about the transmission patterns of the disease in the respective populations. These two building blocks provide the foundation on which the disease control programs can build their policies to expediate control efforts. In this thesis we amalgamate molecular epidemiology, genomics, and proteomics. We studied the transmission pattern of M. tuberculosis and its evolution within a marginalized population. The patterns led to the identification of gaps in TB control policies in marginalized populations with little access to healthcare. Similarly, we studied the genomewide polymorphisms in a naturally attenuated strain - M. bovis strain Ravenel to elucidate possible mechanisms for its reduced virulence and pathogenicity. Insights gained from genome sequence analysis in conjunction with pathogenesis study for M. bovis Ravenel paved the pathway to defining the complex and multi-faceted reasons for attenuation of the oldest bacteria of the world. Next, pathogen-specific biomarkers were evaluated to assist in unambiguous disease detection across multiple host species. Discovery and validation of biomarkers work facilitated the field diagnostic applications for TB in animals and humans. This three-pronged approach developed in this study, understanding the genomic basis of attenuation, and enhanced field TB diagnostics in the animal-human interface.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Epidemiology. $3 568544
650 4 $a Molecular biology. $3 517296
650 4 $a Veterinary services. $3 3433982
653 $a Bovine
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653 $a Epidemiology
653 $a Evolution
653 $a Humans
653 $a Tuberculosis
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710 2 $a Michigan State University. $b Comparative Medicine and Integrative Biology - Doctor of Philosophy. $3 2093084
773 0 $t Dissertations Abstracts International $g 84-02B.
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