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Characterizing the Effects of Subconcussive Impact Biomechanics on Resting-State Brain Hemodynamics and Functional Connectivity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterizing the Effects of Subconcussive Impact Biomechanics on Resting-State Brain Hemodynamics and Functional Connectivity./
Author:	Shearer, Kaden T. .
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	130 p.
Notes:	Source: Masters Abstracts International, Volume: 83-07.
Contained By:	Masters Abstracts International83-07.
Subject:	Biomarkers. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28848861
ISBN:	9798759929451

Characterizing the Effects of Subconcussive Impact Biomechanics on Resting-State Brain Hemodynamics and Functional Connectivity.
Shearer, Kaden T. .

Characterizing the Effects of Subconcussive Impact Biomechanics on Resting-State Brain Hemodynamics and Functional Connectivity. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 130 p.

Source: Masters Abstracts International, Volume: 83-07.

Thesis (M.Sc.)--Queen's University (Canada), 2021.

This item must not be sold to any third party vendors.

Background: The study of impact biomechanics in contact sports has improved our current understanding of concussion mechanisms and the cumulative effects of subconcussive impacts on brain health. Impact exposure is often described by the total insults an athlete sustains or peak magnitude, however, these metrics do not consider underlying properties of the acceleration-time impact profile. It remains unknown whether additional kinematic information can better differentiate impact exposure across positions and session types or characterize subclinical brain changes.Purpose: The objective of this project was to examine potential differences in the biomechanical properties of impacts sustained by collegiate football athletes. These parameters were also used to evaluate changes in functional connectivity and resting perfusion over a season of football.Methods: Helmet accelerometer data were analyzed to characterize subconcussive impact exposure among collegiate football athletes. Impact frequency (per session), peak linear and rotational magnitude, impact duration, area under the acceleration-time curve, impulse, and peak head jerk were used to differentiate mechanical loading events between positional groups, as well as across session types. Resting-state neuroimaging was also used to evaluate the relationship between positional group, impact biomechanics, and concussion history with changes in functional connectivity and resting perfusion in a subset of athletes following subconcussive impact exposure. Results: Biomechanical differences were found in all parameters of interest between session types and positional groups. Several properties of the linear acceleration profile, in addition to rotational velocity, highlighted alterations in regional hemodynamics and functional connectivity within the brain, whereas no such differences were observed using impact count or peak linear acceleration alone. Scaling the functional connectivity data by resting perfusion altered the observed differences in some regions of the brain, highlighting the shared variance that exists between functional network re-organization and perturbations to local physiology following subconcussive impact exposure.Conclusion: These findings indicate that kinematic profile analyses may provide novel insight beyond impact count or peak magnitude that allows for a more complete characterization of impact biomechanics. Altogether, this approach creates a strong paradigm for future studies to examine how these impact parameters relate to injury risk following exposure to repetitive subconcussive head impacts.

ISBN: 9798759929451Subjects--Topical Terms:

2205735
Biomarkers.

Characterizing the Effects of Subconcussive Impact Biomechanics on Resting-State Brain Hemodynamics and Functional Connectivity.
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520 $a Background: The study of impact biomechanics in contact sports has improved our current understanding of concussion mechanisms and the cumulative effects of subconcussive impacts on brain health. Impact exposure is often described by the total insults an athlete sustains or peak magnitude, however, these metrics do not consider underlying properties of the acceleration-time impact profile. It remains unknown whether additional kinematic information can better differentiate impact exposure across positions and session types or characterize subclinical brain changes.Purpose: The objective of this project was to examine potential differences in the biomechanical properties of impacts sustained by collegiate football athletes. These parameters were also used to evaluate changes in functional connectivity and resting perfusion over a season of football.Methods: Helmet accelerometer data were analyzed to characterize subconcussive impact exposure among collegiate football athletes. Impact frequency (per session), peak linear and rotational magnitude, impact duration, area under the acceleration-time curve, impulse, and peak head jerk were used to differentiate mechanical loading events between positional groups, as well as across session types. Resting-state neuroimaging was also used to evaluate the relationship between positional group, impact biomechanics, and concussion history with changes in functional connectivity and resting perfusion in a subset of athletes following subconcussive impact exposure. Results: Biomechanical differences were found in all parameters of interest between session types and positional groups. Several properties of the linear acceleration profile, in addition to rotational velocity, highlighted alterations in regional hemodynamics and functional connectivity within the brain, whereas no such differences were observed using impact count or peak linear acceleration alone. Scaling the functional connectivity data by resting perfusion altered the observed differences in some regions of the brain, highlighting the shared variance that exists between functional network re-organization and perturbations to local physiology following subconcussive impact exposure.Conclusion: These findings indicate that kinematic profile analyses may provide novel insight beyond impact count or peak magnitude that allows for a more complete characterization of impact biomechanics. Altogether, this approach creates a strong paradigm for future studies to examine how these impact parameters relate to injury risk following exposure to repetitive subconcussive head impacts.
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