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The Effects of a Western vs. High Fiber Unprocessed Diet on Health Outcomes in Mice Offspring.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Effects of a Western vs. High Fiber Unprocessed Diet on Health Outcomes in Mice Offspring./
作者:	Herzl, Elizabeth.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	75 p.
附註:	Source: Masters Abstracts International, Volume: 83-12.
Contained By:	Masters Abstracts International83-12.
標題:	Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29206799
ISBN:	9798438767381

The Effects of a Western vs. High Fiber Unprocessed Diet on Health Outcomes in Mice Offspring.
Herzl, Elizabeth.

The Effects of a Western vs. High Fiber Unprocessed Diet on Health Outcomes in Mice Offspring. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 75 p.

Source: Masters Abstracts International, Volume: 83-12.

Thesis (M.S.)--University of Wyoming, 2022.

This item must not be sold to any third party vendors.

Diet influences critical periods of growth, including gestation and early development. We hypothesized that a maternal/early life diet reflecting traditional US Indigenous eating patterns would positively affect offspring metabolic and anthropometric parameters. Using 9 C57BL-6 dams, we simulated exposure to a Western diet (low fiber, high saturated fat [anhydrous milk fat], high sugar), a High Fiber Unprocessed (HFU) diet (high fiber [cellulose], low sugar, low saturated fat), or a Control diet. Once split into diet groups (Western [n=3], HFU [n=3] and Control [n=3]), dams consumed their respective diets through 3 weeks of pregnancy and 3 weeks of weaning; offspring consumed the diet of their mother for 4.5 weeks post-weaning. Measurements included DXA scans (lean mass), feed consumption and body weight, blood glucose measures (glucometer) for dams and offspring, and ELISA assays for insulin and HbA1c in offspring. All statistical analyses were performed using one-way ANOVA with Tukey's post-hoc analysis of dependent variables (glucose, insulin, body mass change, body weight) in relation to diet group. Offspring DXA measures obtained at 5 and 7.5 weeks post-parturition revealed higher lean body mass development in HFU and Control diet offspring compared to Western offspring. Mean statistical comparisons indicated blood glucose (p=0.001) and HbA1c concentrations (p=0.002) were lower among HFU offspring compared to Western and Control offspring, though Control offspring had the lowest insulin concentrations. There were no significant differences among dams. Results demonstrate that nutritional intake during gestation and early life consistent with traditional diet patterns may prevent hyperglycemia and adiposity in offspring.

ISBN: 9798438767381Subjects--Topical Terms:

517777
Nutrition.
Subjects--Index Terms:

Western diet

The Effects of a Western vs. High Fiber Unprocessed Diet on Health Outcomes in Mice Offspring.
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520 $a Diet influences critical periods of growth, including gestation and early development. We hypothesized that a maternal/early life diet reflecting traditional US Indigenous eating patterns would positively affect offspring metabolic and anthropometric parameters. Using 9 C57BL-6 dams, we simulated exposure to a Western diet (low fiber, high saturated fat [anhydrous milk fat], high sugar), a High Fiber Unprocessed (HFU) diet (high fiber [cellulose], low sugar, low saturated fat), or a Control diet. Once split into diet groups (Western [n=3], HFU [n=3] and Control [n=3]), dams consumed their respective diets through 3 weeks of pregnancy and 3 weeks of weaning; offspring consumed the diet of their mother for 4.5 weeks post-weaning. Measurements included DXA scans (lean mass), feed consumption and body weight, blood glucose measures (glucometer) for dams and offspring, and ELISA assays for insulin and HbA1c in offspring. All statistical analyses were performed using one-way ANOVA with Tukey's post-hoc analysis of dependent variables (glucose, insulin, body mass change, body weight) in relation to diet group. Offspring DXA measures obtained at 5 and 7.5 weeks post-parturition revealed higher lean body mass development in HFU and Control diet offspring compared to Western offspring. Mean statistical comparisons indicated blood glucose (p=0.001) and HbA1c concentrations (p=0.002) were lower among HFU offspring compared to Western and Control offspring, though Control offspring had the lowest insulin concentrations. There were no significant differences among dams. Results demonstrate that nutritional intake during gestation and early life consistent with traditional diet patterns may prevent hyperglycemia and adiposity in offspring.
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