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First Foods, Intestinal Ecology, and Early Life Health and Growth Outcomes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	First Foods, Intestinal Ecology, and Early Life Health and Growth Outcomes./
作者:	Washabaugh, Jennifer Renee.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	259 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-11, Section: B.
Contained By:	Dissertations Abstracts International83-11B.
標題:	Biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29069097
ISBN:	9798438787877

First Foods, Intestinal Ecology, and Early Life Health and Growth Outcomes.
Washabaugh, Jennifer Renee.

First Foods, Intestinal Ecology, and Early Life Health and Growth Outcomes. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 259 p.

Source: Dissertations Abstracts International, Volume: 83-11, Section: B.

Thesis (Ph.D.)--University of Colorado at Boulder, 2022.

This item must not be sold to any third party vendors.

Dietary exposures during early life, including our 'first foods' (i.e., mother's milk and non-breast milk foods), have lasting impacts on offspring development. In this dissertation, I explore the impact of first foods on infant health and growth outcomes in a rural population under considerable environmental and physiological stress in The Gambia.I utilize longitudinal data and biological samples collected as a part of the Hormonal and Epigenetic Regulators of Growth (HERO-G) study, which was designed to investigate growth patterns in rural Gambian infants using epigenetic, endocrine, and metabolic analyses. I begin by describing the first foods given over the first year of life in this cohort, including characterization of breastfeeding and complementary feeding practices, and assess some nutritional and bioactive factors in maternal milk across the first year of lactation. Next, I detail infant morbidity occurrences within this cohort across the first year of life, contextualizing infant health outcomes in relationship to diet. Finally, I investigate growth outcomes using anthropometric measurements across the first year of life and test whether first foods and morbidity occurrence exert an effect on weight-for-height (WHZ), height-for-age (HAZ), and/or weight-for-age (WAZ) outcomes. As a part of these investigations, I measure infant fecal pH across the first year of life and explore the relationship of intestinal ecology to environmental stressors and dietary shifts.I identified "real time" and "extended" effects of first foods and breastfeeding practices on infant morbidity and growth at 3, 6, 9, and 12 months of age, demonstrating the persistent contributions of first foods on offspring outcomes. Robust maternal investment in offspring through complex nutritional and immunological milk profiles provides protective effects against illness in infants in this rural Gambian environment, and fewer symptomatic morbidities are associated with features of longitudinal growth. Generating an evidence base that considers both the immediate and longer-term benefits of nutrition in early life is critical to a comprehensive assessment of pathways and underlying mechanisms connecting early life environment to later life outcomes. This project provides important insights into physiological, evolutionary, ecological, and sociocultural influences on nutrition, variation in human milk profiles, and infant health and growth outcomes.

ISBN: 9798438787877Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Anthropology

First Foods, Intestinal Ecology, and Early Life Health and Growth Outcomes.
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