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Lipid metabolism and the ontogeny of acylCoA: Cholesterol acyltransferase and fatty acid-binding protein in developing embryos and post-hatch turkeys.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Lipid metabolism and the ontogeny of acylCoA: Cholesterol acyltransferase and fatty acid-binding protein in developing embryos and post-hatch turkeys./
Author:	Ding, Shih-Torng.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 1996,
Description:	181 p.
Notes:	Source: Dissertations Abstracts International, Volume: 58-02, Section: B.
Contained By:	Dissertations Abstracts International58-02B.
Subject:	Livestock. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9630879
ISBN:	9798209365792

Lipid metabolism and the ontogeny of acylCoA: Cholesterol acyltransferase and fatty acid-binding protein in developing embryos and post-hatch turkeys.
Ding, Shih-Torng.

Lipid metabolism and the ontogeny of acylCoA: Cholesterol acyltransferase and fatty acid-binding protein in developing embryos and post-hatch turkeys. - Ann Arbor : ProQuest Dissertations & Theses, 1996 - 181 p.

Source: Dissertations Abstracts International, Volume: 58-02, Section: B.

Thesis (Ph.D.)--The Ohio State University, 1996.

This item must not be sold to any third party vendors.

To gain insight into lipid utilization of turkey embryos, experiments were conducted to study: (1) lipid and fatty acid distribution and disappearance from yolk sac; (2) ontogeny of acylCoA:cholesterol acyltransferase (ACAT) activity and fatty acid binding protein (FABP) in turkeys. Yolk sac lipids are most extensively utilized during the latter stages of incubation. Enrichment of the maternal (hen) diet with medium chain fatty acids by adding coconut oil changed the yolk lipid fatty acid composition. It resulted in increased incorporation of C 14:0 fatty acids into fresh egg yolk and yolk sac of developing embryos. Fatty acid profile data showed that selection for growth did not influence fatty acid incorporation into yolk lipids. Differences in fatty acid profiles from embryonic yolk sacs, however, may be a reflection of line differences in embryonic growth when line differences in embryonic weight become apparent. There were high levels of ACAT activity in the yolk sac membrane and liver of turkey embryos. The results suggest that the yolk sac membrane and liver play a significant role in embryonic cholesterol esterification and the subsequent packaging of lipids into lipoproteins for transport to other tissues. Total ACAT in intestine increased from embryonic day 16 through day 6 posthatch which suggests that the capacity for intestinal cholesterol esterification increases with stages of development. Turkey hepatic FABP was purified and a quantitative immunoblotting procedure was subsequently developed. Liver FABP increased with length of incubation and this increase was parallel to observed increases in liver lipid accumulation. A sharp increase in intestinal FABP just prior to hatch suggests that it is involved in dietary fatty acid utilization. FABP concentration in the yolk sac membrane plateaued between 16 and 19 days before declining through hatch (day 28). This suggests that FABP in the yolk sac membrane plays a role in lipid transfer from the yolk to the embryo via the yolk sac membrane.

ISBN: 9798209365792Subjects--Topical Terms:

539534
Livestock.

Lipid metabolism and the ontogeny of acylCoA: Cholesterol acyltransferase and fatty acid-binding protein in developing embryos and post-hatch turkeys.
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020 $a 9798209365792
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100 1 $a Ding, Shih-Torng. $3 3688899
245 1 0 $a Lipid metabolism and the ontogeny of acylCoA: Cholesterol acyltransferase and fatty acid-binding protein in developing embryos and post-hatch turkeys.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 1996
300 $a 181 p.
500 $a Source: Dissertations Abstracts International, Volume: 58-02, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Lilburn, Michael S.
502 $a Thesis (Ph.D.)--The Ohio State University, 1996.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a To gain insight into lipid utilization of turkey embryos, experiments were conducted to study: (1) lipid and fatty acid distribution and disappearance from yolk sac; (2) ontogeny of acylCoA:cholesterol acyltransferase (ACAT) activity and fatty acid binding protein (FABP) in turkeys. Yolk sac lipids are most extensively utilized during the latter stages of incubation. Enrichment of the maternal (hen) diet with medium chain fatty acids by adding coconut oil changed the yolk lipid fatty acid composition. It resulted in increased incorporation of C 14:0 fatty acids into fresh egg yolk and yolk sac of developing embryos. Fatty acid profile data showed that selection for growth did not influence fatty acid incorporation into yolk lipids. Differences in fatty acid profiles from embryonic yolk sacs, however, may be a reflection of line differences in embryonic growth when line differences in embryonic weight become apparent. There were high levels of ACAT activity in the yolk sac membrane and liver of turkey embryos. The results suggest that the yolk sac membrane and liver play a significant role in embryonic cholesterol esterification and the subsequent packaging of lipids into lipoproteins for transport to other tissues. Total ACAT in intestine increased from embryonic day 16 through day 6 posthatch which suggests that the capacity for intestinal cholesterol esterification increases with stages of development. Turkey hepatic FABP was purified and a quantitative immunoblotting procedure was subsequently developed. Liver FABP increased with length of incubation and this increase was parallel to observed increases in liver lipid accumulation. A sharp increase in intestinal FABP just prior to hatch suggests that it is involved in dietary fatty acid utilization. FABP concentration in the yolk sac membrane plateaued between 16 and 19 days before declining through hatch (day 28). This suggests that FABP in the yolk sac membrane plays a role in lipid transfer from the yolk to the embryo via the yolk sac membrane.
590 $a School code: 0168.
650 4 $a Livestock. $3 539534
650 4 $a Anatomy & physiology. $3 3434423
650 4 $a Animals. $2 fast $3 518809
690 $a 0475
690 $a 0719
710 2 $a The Ohio State University. $3 718944
773 0 $t Dissertations Abstracts International $g 58-02B.
790 $a 0168
791 $a Ph.D.
792 $a 1996
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9630879