東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Linked to FindBook

Google Book

Amazon

博客來

Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes./
Author:	Kieft, Kristopher.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
Description:	254 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-12, Section: B.
Contained By:	Dissertations Abstracts International83-12B.
Subject:	Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29252476
ISBN:	9798819383704

Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes.
Kieft, Kristopher.

Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 254 p.

Source: Dissertations Abstracts International, Volume: 83-12, Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2022.

This item must not be sold to any third party vendors.

Viruses are omnipresent and influence life processes on micro and macro scales. All viruses require a host cell to replicate, which they accomplish by hijacking the host cells' machinery and resources. Due to this, viruses, especially those that infect microorganisms, are keystone controllers of nutrient and biomass recycling, ecosystem-wide biogeochemical cycling, host population abundances, community interactions, evolutionary momentum, and more. Understanding viruses is critical to the advancement of diverse fields such as agriculture, medicine, industry, ecosystem science, oceanography, and biogeochemistry. Despite their importance, viruses remain difficult to study as they cannot be easily cultivated in a laboratory. Cultivation independent approaches such as metagenomics and viromics can enable the study of uncultivated viruses directly from the environment, though there is a lack of accurate bioinformatics tools to analyze viruses from metagenomes.I am interested in exploring the ecology, evolution, and diversity of viruses in nature and investigating their impacts on global biogeochemical cycles. My dissertation is categorized into two main Aims. Aim one of my research is to use systems biology approaches to expand our understanding of viruses by quantifying their impacts on microorganisms and ecosystems. I will specifically focus on viral encoded genes for assimilatory (Chapter 2) and dissimilatory (Chapter 3) sulfur metabolism. Aim two of my dissertation research is to develop novel bioinformatics tools for the study of viruses in metagenomes and viromes. These approaches will serve as the foundation of next generation virology and studying how viruses fit within microbial communities and global biogeochemical cycles by identifying viral genomes (Chapter 4), deciphering active viruses from DNA sequences (Chapter 5), and constructing viral genomes from mixed communities (Chapter 6). Finally, I provide my observations on where the field of viral genomics stands, established conventions that would benefit from change, and future prospects of the field as a whole (Chapter 7).

ISBN: 9798819383704Subjects--Topical Terms:

553671
Bioinformatics.
Subjects--Index Terms:

Biogeochemistry

Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes.
LDR:03248nmm a2200349 4500 001 2349046
005 20220920134653.5
008 241004s2022 ||||||||||||||||| ||eng d
020 $a 9798819383704
035 $a (MiAaPQ)AAI29252476
035 $a AAI29252476
040 $a MiAaPQ $c MiAaPQ
100 1 $a Kieft, Kristopher. $3 3688433
245 1 0 $a Metagenomics-Enabled Viral Ecology to Advance Our Understanding of Human and Environmental Microbiomes.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2022
300 $a 254 p.
500 $a Source: Dissertations Abstracts International, Volume: 83-12, Section: B.
500 $a Advisor: Anantharaman, Karthik.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2022.
506 $a This item must not be sold to any third party vendors.
520 $a Viruses are omnipresent and influence life processes on micro and macro scales. All viruses require a host cell to replicate, which they accomplish by hijacking the host cells' machinery and resources. Due to this, viruses, especially those that infect microorganisms, are keystone controllers of nutrient and biomass recycling, ecosystem-wide biogeochemical cycling, host population abundances, community interactions, evolutionary momentum, and more. Understanding viruses is critical to the advancement of diverse fields such as agriculture, medicine, industry, ecosystem science, oceanography, and biogeochemistry. Despite their importance, viruses remain difficult to study as they cannot be easily cultivated in a laboratory. Cultivation independent approaches such as metagenomics and viromics can enable the study of uncultivated viruses directly from the environment, though there is a lack of accurate bioinformatics tools to analyze viruses from metagenomes.I am interested in exploring the ecology, evolution, and diversity of viruses in nature and investigating their impacts on global biogeochemical cycles. My dissertation is categorized into two main Aims. Aim one of my research is to use systems biology approaches to expand our understanding of viruses by quantifying their impacts on microorganisms and ecosystems. I will specifically focus on viral encoded genes for assimilatory (Chapter 2) and dissimilatory (Chapter 3) sulfur metabolism. Aim two of my dissertation research is to develop novel bioinformatics tools for the study of viruses in metagenomes and viromes. These approaches will serve as the foundation of next generation virology and studying how viruses fit within microbial communities and global biogeochemical cycles by identifying viral genomes (Chapter 4), deciphering active viruses from DNA sequences (Chapter 5), and constructing viral genomes from mixed communities (Chapter 6). Finally, I provide my observations on where the field of viral genomics stands, established conventions that would benefit from change, and future prospects of the field as a whole (Chapter 7).
590 $a School code: 0262.
650 4 $a Bioinformatics. $3 553671
650 4 $a Biogeochemistry. $3 545717
653 $a Biogeochemistry
653 $a Metagenomics
653 $a Phage
653 $a Virus
690 $a 0715
690 $a 0425
710 2 $a The University of Wisconsin - Madison. $b Microbiology MED. $3 3688434
773 0 $t Dissertations Abstracts International $g 83-12B.
790 $a 0262
791 $a Ph.D.
792 $a 2022
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29252476