東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Linked to FindBook

Google Book

Amazon

博客來

Discovery of small-molecule compounds targeting TREX1.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Discovery of small-molecule compounds targeting TREX1./
Author:	Qian, Junjie.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
Description:	50 p.
Notes:	Source: Masters Abstracts International, Volume: 74-05.
Contained By:	Masters Abstracts International74-05.
Subject:	Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1529049
ISBN:	9781267699541

Discovery of small-molecule compounds targeting TREX1.
Qian, Junjie.

Discovery of small-molecule compounds targeting TREX1. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 50 p.

Source: Masters Abstracts International, Volume: 74-05.

Thesis (M.S.)--University of Southern California, 2012.

Three prime repair exonuclease 1 (TREX1) plays an important role in human DNA repair. More importantly, it has been recently discovered that the 3'→5' DNA exonucleolytic function of TREX1 helps to hide HIV-1 from human innate immune system by digesting nonproductive HIV-1 DNA in cytosol. This new property of TREX1 makes it a promising therapeutic target for anti-HIV drug development. With the purpose of designing and discovering novel inhibitors to this new promising target, we screened diverse sets of drug-like in-house compounds. In addition, the potentials of active compounds serving as dual inhibitors that not only target to TREX1, but also to HIV integrase (IN) were also analyzed. Ultimately, we identified six promising TREX1-inhibitors belonging to five structural classes.

ISBN: 9781267699541Subjects--Topical Terms:

634543
Pharmacology.
Subjects--Index Terms:

Dual inhibitor

Discovery of small-molecule compounds targeting TREX1.
LDR:01916nmm a2200397 4500 001 2348519
005 20220912135558.5
008 241004s2012 ||||||||||||||||| ||eng d
020 $a 9781267699541
035 $a (MiAaPQ)AAI1529049
035 $a (MiAaPQ)usc:13481
035 $a AAI1529049
040 $a MiAaPQ $c MiAaPQ
100 1 $a Qian, Junjie. $3 3687885
245 1 0 $a Discovery of small-molecule compounds targeting TREX1.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2012
300 $a 50 p.
500 $a Source: Masters Abstracts International, Volume: 74-05.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Tokes, Zoltan.
502 $a Thesis (M.S.)--University of Southern California, 2012.
520 $a Three prime repair exonuclease 1 (TREX1) plays an important role in human DNA repair. More importantly, it has been recently discovered that the 3'→5' DNA exonucleolytic function of TREX1 helps to hide HIV-1 from human innate immune system by digesting nonproductive HIV-1 DNA in cytosol. This new property of TREX1 makes it a promising therapeutic target for anti-HIV drug development. With the purpose of designing and discovering novel inhibitors to this new promising target, we screened diverse sets of drug-like in-house compounds. In addition, the potentials of active compounds serving as dual inhibitors that not only target to TREX1, but also to HIV integrase (IN) were also analyzed. Ultimately, we identified six promising TREX1-inhibitors belonging to five structural classes.
590 $a School code: 0208.
650 4 $a Pharmacology. $3 634543
650 4 $a Biochemistry. $3 518028
650 4 $a Pharmacy sciences. $3 3174369
653 $a Dual inhibitor
653 $a HIV
653 $a Inhibitor
653 $a Small molecule
653 $a TREX1
653 $a Therapy
690 $a 0419
690 $a 0487
690 $a 0572
710 2 $a University of Southern California. $b Biochemistry and Molecular Biology. $3 1025323
773 0 $t Masters Abstracts International $g 74-05.
790 $a 0208
791 $a M.S.
792 $a 2012
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1529049