東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

Modelling and development of droplet generation method for magnetically actuated digital microfluidics.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Modelling and development of droplet generation method for magnetically actuated digital microfluidics./
作者:	Hutama, Timothy James.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	147 p.
附註:	Source: Masters Abstracts International, Volume: 79-05.
Contained By:	Masters Abstracts International79-05.
標題:	Fluid mechanics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10707030
ISBN:	9798209585268

Modelling and development of droplet generation method for magnetically actuated digital microfluidics.
Hutama, Timothy James.

Modelling and development of droplet generation method for magnetically actuated digital microfluidics. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 147 p.

Source: Masters Abstracts International, Volume: 79-05.

Thesis (M.S.)--Queen's University (Canada), 2017.

This item must not be sold to any third party vendors.

Digital microfluidics is useful in miniaturizing different types of biological tests due to an ability to perform multiple operations on a single chip with a single common geometry. However, one of the largest problems in using digital microfluidics has been biofouling during these processes, a phenomenon which is exacerbated when using electric fields for fluid manipulation. Magnetic microfluidics is an alternative actuation mechanism, which does not have this same limitation. However, until recently it has been impossible to create drops, which can also be subsequently moved to perform multiple step analyses. In this thesis, a method for creating drops on superhydrophobic surfaces using magnetic force as the primary actuation mechanism is outlined. Using numerical simulations in Comsol Multiphysics, the method was explored to determine several of the limitations of the system, including the minimum actuatable volume (5 μL). Additionally, the flow within the drops was explored to obtain a better understanding of the experimental results. Experimental validation of the results followed, and it was found that the system showed a 1-to-1 linear change in drop volume relative to expected dispensed volume, verifying the theoretical model. Experimental validation found that the error of the system is constant over any dispensed volume at ±0.5 μL. The method was applied to miniaturize a standard test for hard water determination, a complexometric EDTA titration. The results from a specially designed chip are compared to a titration of a 10 mL volume of the same sample and two were found to be equal within error (100-170 ppm for the chip, 124±2 ppm for the standard method). The water hardness estimate from the chip was further improved upon by image analysis, and the range narrowed to 120±15 ppm, again within the same error as the standard method. Together with the theoretical analysis, this result verifies the practicality of the method for analytical operations. Finally, preliminary work into making the magnetic droplet manipulation method more general was conducted, and it was found to be possible to create chips which utilize any combination of droplet mixing, merging, moving, and splitting.

ISBN: 9798209585268Subjects--Topical Terms:

528155
Fluid mechanics.

Modelling and development of droplet generation method for magnetically actuated digital microfluidics.
LDR:03340nmm a2200337 4500 001 2348495
005 20220912135554.5
008 241004s2017 ||||||||||||||||| ||eng d
020 $a 9798209585268
035 $a (MiAaPQ)AAI10707030
035 $a (MiAaPQ)QueensUCan197422805
035 $a AAI10707030
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hutama, Timothy James. $3 3687859
245 1 0 $a Modelling and development of droplet generation method for magnetically actuated digital microfluidics.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 147 p.
500 $a Source: Masters Abstracts International, Volume: 79-05.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Oleschuk, Richard.
502 $a Thesis (M.S.)--Queen's University (Canada), 2017.
506 $a This item must not be sold to any third party vendors.
520 $a Digital microfluidics is useful in miniaturizing different types of biological tests due to an ability to perform multiple operations on a single chip with a single common geometry. However, one of the largest problems in using digital microfluidics has been biofouling during these processes, a phenomenon which is exacerbated when using electric fields for fluid manipulation. Magnetic microfluidics is an alternative actuation mechanism, which does not have this same limitation. However, until recently it has been impossible to create drops, which can also be subsequently moved to perform multiple step analyses. In this thesis, a method for creating drops on superhydrophobic surfaces using magnetic force as the primary actuation mechanism is outlined. Using numerical simulations in Comsol Multiphysics, the method was explored to determine several of the limitations of the system, including the minimum actuatable volume (5 μL). Additionally, the flow within the drops was explored to obtain a better understanding of the experimental results. Experimental validation of the results followed, and it was found that the system showed a 1-to-1 linear change in drop volume relative to expected dispensed volume, verifying the theoretical model. Experimental validation found that the error of the system is constant over any dispensed volume at ±0.5 μL. The method was applied to miniaturize a standard test for hard water determination, a complexometric EDTA titration. The results from a specially designed chip are compared to a titration of a 10 mL volume of the same sample and two were found to be equal within error (100-170 ppm for the chip, 124±2 ppm for the standard method). The water hardness estimate from the chip was further improved upon by image analysis, and the range narrowed to 120±15 ppm, again within the same error as the standard method. Together with the theoretical analysis, this result verifies the practicality of the method for analytical operations. Finally, preliminary work into making the magnetic droplet manipulation method more general was conducted, and it was found to be possible to create chips which utilize any combination of droplet mixing, merging, moving, and splitting.
590 $a School code: 0283.
650 4 $a Fluid mechanics. $3 528155
650 4 $a Applied physics. $3 3343996
650 4 $a Physical chemistry. $3 1981412
690 $a 0204
690 $a 0215
690 $a 0494
710 2 $a Queen's University (Canada). $3 1017786
773 0 $t Masters Abstracts International $g 79-05.
790 $a 0283
791 $a M.S.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10707030