東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Linked to FindBook

Google Book

Amazon

博客來

Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia./
Author:	Joseph, Shaylyn.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	157 p.
Notes:	Source: Masters Abstracts International, Volume: 83-06.
Contained By:	Masters Abstracts International83-06.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28644522
ISBN:	9798496549431

Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia.
Joseph, Shaylyn.

Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 157 p.

Source: Masters Abstracts International, Volume: 83-06.

Thesis (M.Sc.)--University of Toronto (Canada), 2021.

This item must not be sold to any third party vendors.

Electroencephalography (EEG) studies of Alzheimer's Dementia (AD) have shown evidence of cortical hyper-excitability, however, its relationship with cognition and neuropsychiatric symptoms (NPS) remains unclear. Objectives: First, we conducted a system review and meta-analyses to quantitatively synthesis the evidence of cortical excitability in AD and its relationship with clinical symptoms. Next, we compared dorsolateral prefrontal cortex (DLPFC) excitability between AD and older healthy individuals using transcranial magnetic stimulation paired with EEG and assessed its relationship with cognition and NPS in AD. Hypothesis: We hypothesized increased cortical excitability in AD would be inversely associated with cognition and positively associated with NPS. Results: There is increased motor cortex and DLPFC excitability in AD as compared to healthy individuals. Additionally, DLPFC excitability was inversely associated with global cognition and executive functioning, and positively associated with NPS burden in AD. Conclusions: These findings help in understanding the mechanisms underlying AD and its associated clinical symptoms.

ISBN: 9798496549431Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Alzheimer's dementia

Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia.
LDR:02359nmm a2200397 4500 001 2346644
005 20220620110705.5
008 241004s2021 ||||||||||||||||| ||eng d
020 $a 9798496549431
035 $a (MiAaPQ)AAI28644522
035 $a AAI28644522
040 $a MiAaPQ $c MiAaPQ
100 1 $a Joseph, Shaylyn. $3 3685790
245 1 0 $a Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 157 p.
500 $a Source: Masters Abstracts International, Volume: 83-06.
500 $a Advisor: Kumar, Sanjeev.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Electroencephalography (EEG) studies of Alzheimer's Dementia (AD) have shown evidence of cortical hyper-excitability, however, its relationship with cognition and neuropsychiatric symptoms (NPS) remains unclear. Objectives: First, we conducted a system review and meta-analyses to quantitatively synthesis the evidence of cortical excitability in AD and its relationship with clinical symptoms. Next, we compared dorsolateral prefrontal cortex (DLPFC) excitability between AD and older healthy individuals using transcranial magnetic stimulation paired with EEG and assessed its relationship with cognition and NPS in AD. Hypothesis: We hypothesized increased cortical excitability in AD would be inversely associated with cognition and positively associated with NPS. Results: There is increased motor cortex and DLPFC excitability in AD as compared to healthy individuals. Additionally, DLPFC excitability was inversely associated with global cognition and executive functioning, and positively associated with NPS burden in AD. Conclusions: These findings help in understanding the mechanisms underlying AD and its associated clinical symptoms.
590 $a School code: 0779.
650 4 $a Neurosciences. $3 588700
650 4 $a Gerontology. $3 533633
650 4 $a Pathology. $3 643180
650 4 $a Health care management. $3 2122906
650 4 $a Cognitive psychology. $3 523881
650 4 $a Biophysics. $3 518360
653 $a Alzheimer's dementia
653 $a Cognition
653 $a Neuropsychiatric symptoms
653 $a Transcranial magnetic stimulation
690 $a 0317
690 $a 0786
690 $a 0633
690 $a 0769
690 $a 0571
690 $a 0351
710 2 $a University of Toronto (Canada). $b Medical Science. $3 3182952
773 0 $t Masters Abstracts International $g 83-06.
790 $a 0779
791 $a M.Sc.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28644522